1. Located at ENSCR RENNES - FRANCE Your Ideal R&D partner and Custom Synthesis Solution

2. HPC Pharma offers Highly Potent Compounds R&D Custom Synthesis (from mg to 100g) Impurities Contract Research - Feasibility Studies Process Development Support www.hpc-pharma.com

3. Why choose HPC Pharma? Possibility to work on Highly Potent Compounds Specific Security and Quality procedures Fully equipped and independent Organic Synthesis laboratory Optimized and continuous communication/confidentiality policy Access to a multitude of analytical equipments Experience in various types of organic chemistry Capacity: 100g of HPAPI www.hpc-pharma.com

4. Highly Potent R&D Services on Highly Potent compounds Restricted access Laboratory Specific WEISS Workstation for the manipulation of Highly Potent Compounds Significant Expertise and technical know-how Use of specific quality/security procedures Capacity: Up to 100g of HPAPIs www.hpc-pharma.com

5. Custom Synthesis from mg to 100g You define the target, the specs and the amount Top-level expertise in Organic Chemistry: antivirals, oncological APIs, stereospecific synthesis, natural products, enantiomeric resolution, purification techniques… Capacity: Up to 100g 1L, 5L, DE reactors -20°C to 180°C (-78°C to 250°C on small scale) We discuss together the feasibility, the cost and the deadlines We take it from here and produce your compound according to the defined criteria www.hpc-pharma.com

6. Impurities Got a problem with isolating an unreferenced impurity? Demonstrated experience in identification, isolation, production of a reference standard Access to a multitude of analytical tools (HPLC, NMR, X-Rays, UV, IR, Mass-spec…) www.hpc-pharma.com

7. Contract Research & Feasibility Studies Discovered a promising active compound ? Bibliographic study Synthesis & purification development Upscaling & Production of a reference batch The detailed methods & and the complete feasibility study www.hpc-pharma.com

8. Process Development Support Need to optimize your Process? Valuable experience in process development Study of specific production steps (1L, 5L DE reactors, from -20°C to 180°C) Production of reference standards to support your process (up to 100g) Small scale purification development www.hpc-pharma.com

9. Equipment Fully equipped & independent organic synthesis laboratory Specific WEISS Workstation for Highly Potent Compounds Complete and open access to a multitude of analytical facilities: HPLC, 400MHz NMR, X-Rays, Mass-Spec, Uv, IR, DSC, DGA, DTA… www.hpc-pharma.com

10. Your project is in experienced and caring hands… COMPETENCE FLEXIBILIY COMMUNICATION PERFORMANCE RELIABILITY www.hpc-pharma.com

11. Feel free to contact us! Dr Yazan El Safadi yazan.elsafadi@hpc-pharma.com Tel: +33(0)2 23 23 81 21 Mob: +33(0)6 76 83 83 43 www.hpc-pharma.com Tel: +33 (0)2 23 23 81 21 Mob: +33 (0)6 76 83 83 43 HPC Pharma – ENSCR, Avenue du Général Leclerc – 35708 – RENNES, FRANCE