he common underlying manifestation of this group of illnesses is the presence of chronic synovitis, or inflammation of the joint synovium. The synovium becomes thickened and hypervascular with infiltration by lymphocytes, which also can be found in the synovial fluid along with inflammatory cytokines. The inflammation leads to the production and release of tissue proteases and collagenases, which if left untreated can lead to tissue destruction, particularly of the articular cartilage and eventually the underlying bony structures.
Cervical lymphadenopathy is found in 70% of children and should be greater than 1.5 cm in diameter for the purposes of diagnosis. , which can vary in appearance, occurs in 80% of children with KD and may be particularly accentuated in the inguinal area and on the chest.
which usually appear in the subacute and convalescent phases, and pose the highest risk of sudden death. Risk factors for development of coronary artery aneurysms include prolonged fever, prolonged elevation of inflammatory parameters such as the ESR, age younger than 1 year, and male gender. Body_ID: P088005 page 430 page 431 Body_ID: P0431