Molecular biology

1. Antibacterial protein’s molecular
workings revealed
( February 21/2013)
General mechanism that accelerates
tumor development discovered
(February 24/2013)
ALEXANDER BETANCUR
SALAZAR
Medical student

4. Introduction:
proteins are responsible for
Are linear chains of everything happens normally,
amino acids essential so that its function is to guide
for the proper the flow of electrons through
functioning of the body. the membrane

5. Antibacterial protein’s molecular workings
revealed
( February 21/2013)

6. Antibacterial protein’s molecular
workings revealed
The study is based on a major public health
problems common today and is the bacterial
resistance to antibiotics and it is difficult to find
effective treatments for diseases
for this, the researchers focused
on the protein calprotectin even
seek to clarify its structure,
function the way they act and the
effect on bacterial pathogens
interact with metal nutrients.

7. Antibacterial protein’s molecular
workings revealed
On the front of our defenses against
protein calprotectin is bacteria, which "
starving "of invading pathogens
metal nutrients.
In a series of preliminary studies, Skaar,
Walter Chazin, Ph.D., and Richard Caprioli,
Ph.D., showed that calprotectin is highly
expressed by the host immune cells at sites
of infection.

8. Antibacterial protein’s molecular
workings revealed
They showed that calprotectin inhibits
bacterial growth by "cleaning" manganese
and zinc that bacteria need for replication.

9. PERSONAL
OPINION and extensive
thanks to technological advances
studies of medicine especially in the area has
allowed deeper molecular and problems to solve
before we could not possibly.
And it is from the molecular level is
that nowadays are designing new
therapies that effectively have solved
several health problems, in this case
the problem of bacterial resistance to
the therapy

10. General mechanism that
accelerates tumor development
discovered (February 24/2013)

11. General mechanism that
accelerates tumor development
discovered
The research is based
on the study of some
proteins that help the
right direction and
have a therapeutic
strategy to effectively
fight diseases like
cancer.

12. Cancer is characterized by
uncontrolled cell division and
growth. To identify new
therapeutic targets through
which to address disease,
scientists seek to clarify the
mechanisms that control the
expression of genes that favor
the development of tumors, in
processes such as cell division
control.

13. CPEB family comprises four
proteins,
Mutually offsetting normal function
But they have specific activities in
Disease states. "This is Finding
Positive from the therapeutic point
of view,
because it means that if you
remove the CPEB1
Healthy cells, Its function can be
assumed
For any other protein CPEB

14. The laboratory has developed a system for
detecting a therapeutic drug molecules that
can inhibit the action of CPEB in tumors while
having few side effects on healthy cells. There
is no drug presently available which influences
the regulation of gene expression at this level.
Our results open a
pioneering therapeutic
window. We are
optimistic about the
potential of CPEB
proteins as targets.

15. PERSONAL OPINION
Cancer is a disease that always gives that speech, is a
disease in which it is more difficult to get effective treatments
because of its constantly changing, so it is very important to
always being able to find therapeutic targets to treat, which in
this case CPEB1 are strong indications that have proven to be
a very viable proposal if it comes to perfecting
CPEB1:Your function is cut
the regions of RNA and
avoid the genetic
information of cell
proliferation carcinogenic.

16. MEDICAL UTILITY

17. Medical Utility:
understanding the
different mechanisms of
action and different
functions of vital body
molecules allows us
through molecular
biology make this a
useful tool that allows us
to identify specific areas
that help us to get a
solution to various
health problems.

18. Besides the
different starting
points to piece
together the puzzle
that is in the
provision of
appropriate
treatment for a
patient

19. Bibliography
 Martinez LM, et al. Biología Molecular. 6ta Ed. Medellin:
UPB, 2011. Pgs 112 - 115
 Antibacterial protein’s molecular workings revealed .
ScienceDaily; February 21, 2013 [online]:
http://www.sciencedaily.com/releases/2013/02/130221
115918.htm
 General mechanism that accelerates tumor
development discovered. ScienceDaily; February 24,
2013 [online]:
http://www.sciencedaily.com/releases/2013/02/130224
142827.htm
 http://www.wordreference.com/definicion/proteína

20. Gracias!.