Multiple Alleles

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MULTIPLE ALLELES Genes which have more than two alleles © 2007 Paul Billiet ODWS

Genes and their alleles ,[object Object],[object Object],[object Object],© 2007 Paul Billiet ODWS

Combinations ,[object Object],[object Object],[object Object],[object Object],© 2007 Paul Billiet ODWS

Genes and the immune system ,[object Object],[object Object],[object Object],© 2007 Paul Billiet ODWS

The ABO blood system ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],© 2007 Paul Billiet ODWS

The ABO blood system ,[object Object],[object Object],[object Object],© 2007 Paul Billiet ODWS O ii B I B i B I B I B A I A i AB I A I B A I A I A Phenotypes (Blood types) Genotypes

Blood types and transfusions ,[object Object],[object Object],[object Object],© 2007 Paul Billiet ODWS

Antigens © Biology Labs Online © Bioformatica

Agglutination © Dr Delphine Grézel, Ecole Nationale Vétérinaire de Lyon

Blood types and transfusions ,[object Object],[object Object],[object Object],[object Object],© 2007 Paul Billiet ODWS

Donor-recipient compatibility ,[object Object],[object Object],[object Object],© 2007 Paul Billiet ODWS O AB B Donor A O AB B A Type Recipient = Safe transfusion = Agglutination

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Features of multiple alleles. The same genes have more than two alleles. All multiple alleles in homologous chromosomes occupy the respective loci. A chromosome or gamete only has one group allele. Each human contains only two separate gene alleles, one for each homologous pair of chromosomes carrying the gene. More than two alternative alleles of a gene are known as multiple alleles in a population occupying the same locus on a chromosome or its homologue. ... Multiple alleles express various alternatives of one trait. Different alleles can exhibit codominance, dominance-recessive behaviour or incomplete dominance.

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Examples of Codominance. The best example, in this case, is the codominance blood type. ABO group is considered to be a codominant blood group where both father’s and mother’s blood group is expressed. It means that the properties of the blood groups exist in the ABO type. Codominance is a relationship between two versions of a gene. Individuals receive one version of a gene, called an allele, from each parent. If the alleles are different, the dominant allele usually will be expressed, while the effect of the other allele, called recessive, is masked.

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If a doctor talks about your blood type, usually he or she is referring to two things: your type in the ABO system and Rhesus (Rh) factor. Human blood type is determined by antigens on the red blood cells. An antigen is a structure on the cell surface that causes a human immune response reacts to if the structure is foreign to the person’s body. Consequently, blood type match is of crucial importance. The donor’s blood type is identified at the Blood Centre, and the patient’s blood type is determined before transfusion. Here is everything you need to know!

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1 BIOL 102: Lab 9 Simulated ABO and Rh Blood Typing Objectives: After completing this laboratory assignment, students will be able to: • explain the biology of blood typing systems ABO and Rh • explain the genetics of blood types • determine the blood types of several patients Introduction: Before Karl Landsteiner discovered the ABO human blood groups in 1901, it was thought that all blood was the same. This misunderstanding led to fatal blood transfusions. Later, in 1940, Landsteiner was part of a team who discovered another blood group, the Rh blood group system. There are many blood group systems known today, but the ABO and the Rh blood groups are the most important ones used for blood transfusions. The designation Rh is derived from the Rhesus monkey in which the existence of the Rh blood group was discovered. Although all blood is made of the same basic elements, not all blood is alike. In fact, there are eight different common blood types, which are determined by the presence or absence of certain antigens – substances that can trigger an immune response if they are foreign to the body – on the surface of the red blood cells (RBCs also known as erythrocytes). ABO System: The antigens on RBCs are agglutinating antigens or agglutinogens. They have been designated as A and B. Antibodies against antigens A and B begin to build up in the blood plasma shortly after birth. A person normally produces antibodies (agglutinins) against those antigens that are not present on his/her erythrocytes but does not produce antibodies against those antigens that are present on his/her erythrocytes. • A person who is blood type A will have A antigens on the surface of her/his RBCs and will have antibodies against B antigens (anti-B antibodies). See picture below. • A person with blood type B will have B antigens on the surface of her/his RBCs and will have antibodies against antigen A (anti-A antibodies). • A person with blood type O will have neither A nor B antigens on the surface of her/his RBCs and has BOTH anti-A and anti-B antibodies. • A person with blood type AB will have both A and B antigens on the surface of her/his RBCs and has neither anti-A nor anti-B antibodies. The individual’s blood type is based on the antigens (not the antibodies) he/she has. The four blood groups are known as types A, B, AB, and O. Blood type O, characterized by an absence of A and B agglutinogens, is the most common in the United States (45% of the population). Type A is the next in frequency, found in 39% of the population. The incidences of types B and AB are 12% and 4%, respectively. 2 Table 1: The ABO System Blood Type Antigens on RBCs Antibodies in the Blood Can GIVE Blood to Groups: Can RECEIVE Blood from Groups: A A Anti-B A, AB O, A B B Anti-A B, AB O, B AB A and B Neither anti-A nor anti-B AB O, A, B, AB O Neither A nor B Both anti-A.

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Multiple Alleles

1. MULTIPLE ALLELES Genes which have more than two alleles © 2007 Paul Billiet ODWS

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8. Antigens © Biology Labs Online © Bioformatica

9. Agglutination © Dr Delphine Grézel, Ecole Nationale Vétérinaire de Lyon

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