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CHARACTERISTICS AND SYMPTOMS OF ALZHEIMER’S It is often difficult to distinguish between normal decline in mental
functioning due to aging and the onset of AD. There are fairly distinctive stages of AD, but it is important to realize that each
individual with Alzheimer’s can present with different combinations of characteristics. However, all have the general symptoms of
decline
in memory, functionality, and behavior.
STAGES OF ALZHEIMER’S DISEASE Preclinical Alzheimer’s: The entorhinal cortex is the area of the brain in which AD begins.
It forms the input to the hippocampus and is responsible for the pre-processing of input signals. The hippocampus is located in the
temporal lobe of the brain and together with the entorhinal cortex is responsible for memory and navigation. Deterioration in these
areas probably occurs 10 to 20 years before signs or symptoms of AD are noted. These regions begin to atrophy (shrink) and
memory loss is usually the first feature. Mild cognitive impairment (MCI) is a condition that has
similarities to preclinical AD. However, it is not entirely clear if they are identical. MCI is a condition characterized by mild
recent memory loss, without dementia or significant impairment of other cognitive functions beyond that expected for age
or educational background. The research suggests that many patients with MCI progress to AD. What is important about
MCI is that this condition is increasingly being treated with AD medications in an attempt to slow down progression (or
conversion) to AD or worsening function.
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