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Avian Influenza (H5N1) Expert System using Dempster-Shafer Theory


       Andino Maseleno
       Department of Computer Science, Faculty of Science, Universiti Brunei Darussalam
       Jalan Tungku Link, Gadong BE 1410, Negara Brunei Darussalam
       E-mail: andinomaseleno@yahoo.com


       Md. Mahmud Hasan
       Department of Computer Science, Faculty of Science, Universiti Brunei Darussalam
       Jalan Tungku Link, Gadong BE 1410, Negara Brunei Darussalam
       mahmud.hasan@ubd.edu.bn


       Abstract: Based on Cumulative Number of Confirmed Human Cases of Avian Influenza (H5N1)
       Reported to World Health Organization (WHO) in the 2011 from 15 countries, Indonesia has the
       largest number death because Avian Influenza which 146 deaths. In this research, the researcher
       built an Avian Influenza (H5N1) Expert System for identifying avian influenza disease and
       displaying the result of identification process. In this paper, we describe five symptoms as major
       symptoms which include depression, combs, wattle, bluish face region, swollen face region,
       narrowness of eyes, and balance disorders. We use chicken as research object. Dempster-Shafer
       theory to quantify the degree of belief as inference engine in expert system, our approach uses
       Dempster-Shafer theory to combine beliefs under conditions of uncertainty and ignorance, and
       allows quantitative measurement of the belief and plausibility in our identification result. The
       result reveal that Avian Influenza (H5N1) Expert System has successfully identified the existence
       of avian influenza and displaying the result of identification process.

       Keywords: avian influenza (H5N1), expert system, uncertainty, dempster-shafer theory


       eference to this paper should be made as follows: Maseleno, A. and Mahmud Hasan, Md. (2012) ‘Avian Influenza
       (H5N1) Expert System using Dempster-Shafer Theory’, Int. J. Information and Communication Technology, Vol. 4,
       No. 2


       Biographical notes: Andino Maseleno is a Ph.D. student in the Department of Computer Science, University
       Brunei Darussalam. His research interest is in the area of artificial intelligence. He receive Graduate Research
       Scholarship (GRS) from Duli Yang Maha Mulia Sultan Haji Hassanal Bolkiah.
       Dr. Md. Mahmud Hasan is a Senior Lecturer in the Deptartment of Computer Science, University Brunei
       Darussalam. His research interest is in the areas of Internet Appliances, artificial intelligence and embedded
       system. He has 35 publications in the international and national journal/conferences/book chapters. Also hold
       a patent over the “Internet appliance for ECG”.



1 Introduction
Historically, outbreaks of avian influenza first occurred in Italy in the 1878, when it was a lot of dead birds [1]. Then
came another outbreak of Avian Influenza in Scotland in the 1959 [2]. The virus that causes Avian Influenza in Italy
and Scotland are the current strain of H5N1 virus appeared again attacked poultry and humans in various countries in
Asia, including Indonesia, which caused many deaths in humans [3].
   Avian influenza virus H5N1, which has been limited to poultry, now has spread to migrating birds and has emerged
in mammals and among the human population. It presents a distinct threat of a pandemic for which the World Health
Organization and other organizations are making preparations. In the 2005, the World Health Assembly urged its
Member States to develop national preparedness plans for pandemic influenza [4]. Developing countries face particular
planning and other challenges with pandemic preparedness as there may be a higher death rate in developing countries
compared with more developed countries [5].
Expert System is a computer application of artificial intelligence [6],[8],[9] which contains a knowledge base and an
inference engine [7]. Since such programs attempt to emulate the thinking patterns of an expert, it is natural that the first
work was done in artificial intelligence circles. Among the first expert systems were the 1965 Dendral programs [10],
which determined molecular structure from mass spectrometer data; R1 [11] used to configure computer systems; and
MYCIN [12] for medical diagnosis. The basic idea behind expert system is simply that expertise, which is the vast body
of task-specific knowledge, is transferred from a human to a computer. This knowledge is then stored in the computer
and users call upon the computer for specific advice as needed. The computer can make inferences and arrive at a
specific conclusion. Then like a human consultant, it gives advices and explains, if necessary, the logic behind the
advice [13]. Some expert systems for diagnosis in avian influenza have been developed which were expert system for
avian influenza disease using Visual Basic.NET [14], and web based [15]. Actually, according to researchers
knowledge, Dempster-Shafer theory of evidence has never been used for built an expert system for identifying avian
influenza.
    The remainder is organized as follows. The uncertainty in expert system is briefly reviewed in Section 2. Section 3
details the proposed Dempster-Shafer Theory. Architecture of Avian Influenza (H5N1) Expert System in Section 4. The
experimental results are presented in Section 5, and final remarks are concluded in Section 6.


2 Uncertainty in Expert System
The construction of expert and other intelligent computer systems requires sophisticated mechanism for representing
and reasoning with uncertain information. At least three forms of uncertainty can be identified as playing a significant
role in these types of systems. The first of these possibilistic uncertainty appears in situations where the value of a
variable can only be narrowed down to a set of values one of which is the actual value of the variable. The second kind
of uncertainty is related to situations in which there exists uncertainty as to satisfaction of a predicate by an element.
This is manifested by concepts which have imprecise or gray boundaries. A very powerful tool for handling this type of
uncertainty which also handles the first type of uncertainty is the fuzzy set. The third type of uncertainty is related to
situations in which the value of a variable assumes can be modeled by the performance of a random experiment [16].
Figure 1 shows the process for dealing with uncertainty in Avian Influenza (H5N1) Expert System.

Figure 1 The process for dealing with uncertainty in Avian Influenza (H5N1) Expert System

                                Step 1




                                 Representation of uncertainty   Alternative Rule
                                   on the set of basic events




                                Step 2                                Step 3




                                Merging uncertain information                       Conclusion




    In step 1, an expert provides uncertain knowledge in the form of rules with the possibility. These rules are
probability values. In step 2, the uncertain knowledge on a set of basic events can be directly used to draw conclusions
in simple cases (step 3). However, in many cases the various events associated with each other. Therefore, it is
necessary to combine the information contained in step 1 into the global value system. In step 3, the goal is knowledge-
based systems draw conclusions. It is derived from uncertain knowledge in steps 1 and 2, and is usually implemented by
an inference engine. Working with the inference engine, the expert can adjust the input that they enter in step 1 after
displaying the results in step 2 and step 3.
3 Dempster-Shafer Theory

The Dempster-Shafer theory was first introduced by Dempster [17] and then extended by shafer [18], but the kind of
reasoning the theory uses can be found as far back as the seventeenth century. This theory is actually an extension to
classic probabilistic uncertainty modeling. Whereas the Bayesian theory requires probabilities for each question of
interest, belief functions allow us to base degrees of belief for on question on probabilities for a related question. The
advantages of the Dempster-Shafer theory as follows:
1. It has the ability to model information in a flexible way without requiring a probability to be assigned to each
    element in a set,
2. It provides a convenient and simple mechanism (Dempster's combination rule) for combining two or more pieces of
    evidence under certain conditions.
3. It can model ignorance explicitly.
4. Rejection of the law of additivity for belief in disjoint propositions.
Avian Influenza (H5N1) Expert System using Dempster-Shafer theory in the decision support process. Flowchart of
Avian Influenza (H5N1) Expert System shown in Figure 2.

Figure 2 Flowchart of Avian Influenza (H5N1) Expert System


                                      Start




                                                   Yes                 Input
                                     Symptoms                      m1 (B) m2 (C)




                                            No


                                     m (A) = 1




                                          End




The consultation process begins with selecting the symptoms. If there are symptoms then will calculate, The Dempster-
Shafer theory provides a rule to combine evidences from independent observers and into a single and more informative
hint. Evidence theory is based on belief function and plausible reasoning. First of all, we must define a frame of
discernment, indicated by the sign Θ . The sign 2Θ indicates the set composed of all the subset generated by the frame of
discernment. For a hypothesis set, denoted by A, m(A)→[0,1].
       m( )=0

                                                                                                                       (1)

  is the sign of an empty set. The function m is the basic probability assignment. Dempster's rule of combination
combines two independent sets of mass assignments.
                   ( )=0                                                                                      (2)

                                                                                                                      (3)
Where

                                                                                                                      (4)
                                 [    ]
The results reveal that Avian Influenza (H5N1) Expert System successfully identifying disease and displaying the
result of identification process.


4 Avian Influenza (H5N1) Expert System

Avian Influenza (H5N1) Expert System has four main architectural components that are the knowledge base, the
inference engine, the knowledge acquisition module, and the user interface for input/output. Figure 3 shows architecture
of Avian Influenza (H5N1) Expert System.

Figure 3 Architecture of Avian Influenza (H5N1) Expert System



                                 Knowledge Acquisition




                                    Knowledge Base




                                    Inference Engine                    User Interface




4.1 Knowledge acquisition
In the present work, knowledge has been obtained from two sources. We acquired textual information from literature
such as extension booklets, reports, papers, etc., related to the avian influenza diseases. The printed material allowed
became familiar with the subject and a more effective communication with the experts. Most knowledge was acquired
from the experts using conventional interviewing techniques. The interview methods permitted a better understanding
of the problem and its further representation. This knowledge was provided by experts on avian influenza. Unstructured
and structured interviews were used. The unstructured interviews were used to define the familiar tasks involved in the
process of identification, to obtain an initial understanding of the range of complications involved, and to define specific
problems for later discussion. The questions were more or less spontaneous and notes were taken on discussion. These
methods were complemented with structured interviews. In the structured interviews, we revised and discussed in depth
familiar tasks to clarify questions.

4.2 Knowledge base
A critical aspect of building an expert system is formulating the scope of the problem and gleaning from the source
expert the domain information needed to solve the problem. The reliability of an expert system depends on the quality
of knowledge contained in the knowledge base. In this research, we built a Avian Influenza (H5N1) Expert System and
we describe five symptoms which include depression, combs, wattle, bluish face region, swollen face region,
narrowness of eyes, and balance disorders. Knowledge of which input on the testing of this expert system can be seen in
table 1. Supposed we have five different conditions.
Table 1 Knowledge base

Symptom                  Disease                                    Basic Probability Assignment
                                                   Condition     Condition   Condition     Condition       Condition
                                                      1             2            3             4              5
Depression               Avian Influenza             0.7           0.9          0.8           0.9            0.6
                         Newcastle Disease
                         Fowl Cholera
                         Infectious Bronchitis
                         Respiratory Form
                         Infectious Bronchitis
                         Reproduction Form
                         Swollen Head
                         Syndrome
Combs, Wattle, Bluish    Avian Influenza              0.9           0.8           0.9              0.6        0.7
Face Region
Swollen Face Region      Avian Influenza             0.83           0.9           0.6              0.7        0.9
                         Newcastle Disease
                         Fowl Cholera
Narrowness of Eyes       Swollen Head                 0.9           0.6           0.7              0.9        0.8
                         Syndrome
Balance Disorders        Newcastle Diseases           0.6           0.7           0.9              0.8        0.9
                         Swollen Head
                         Syndrome


4.3 Inference Engine
The inference engine is charged with the role of performing and controlling inference on the knowledge base. Specific
features of the inference engine depend on the knowledge representation scheme used for the knowledge base. Because
the most common representation scheme is production rules, this inference engine will be exemplified. In this research
we use forward chaining inference engine using Dempster-Shafer Theory. The following will be shown the inference
engine using Dempster-Shafer Theory to diagnose avian influenza in condition 1.
Symptoms:
1. Depression
2. Combs, wattle, bluish face region
3. Swollen face region
4. Narrowness of eyes
5. Balance disorder


Symptom 1
   Depression is a symptom of Avian Influenza (AI), Newcastle Disease (ND), Fowl Cholera (FC), Infectious
Bronchitis respiratory form (IBRespi), Infectious Bronchitis reproduction form (IBRepro), and Swollen Head Syndrome
(SHS). The measures of uncertainty, taken collectively are known in Dempster-Shafer Theory terminology as a ``basic
probability assignment'' (bpa). Hence we have a bpa, say m1 of 0.7 given to the focal element {AI, ND, FC, IBRespi,
IBRepro, SHS} in example, m1({AI, ND, FC, IBRespi, IBRepro, SHS}) = 0.7, since we know nothing about the
remaining probability it is allocated to the whole of the frame of the discernment in example, m1({AI, ND, FC, IBRespi,
IBRepro, SHS}) = 0.3, so:
m1{AI, ND, FC, IBRespi, IBRepro, SHS} = 0.7
m1{Θ} = 1 - 0.7 = 0.3

Symptom 2
   Combs, wattle, bluish face region are symptoms of Avian Influenza with a bpa of 0.9, so that:
m2{AI} = 0.9
m2 {Θ} = 1 – 0.9 = 0.1
We combining symptom 1, and symptom 2 as seen in the table 2.
Table 2 Combination of symptom 1, and symptom 2

                        {AI}                                  0.9                   Θ                           0.1
 {AI, ND, FC, IBRespi, IBRepro, SHS}      0.7      {AI}      0.63   {AI, ND, FC, IBRespi, IBRepro, SHS}        0.07
 Θ                                        0.3      {AI}      0.27                   Θ                          0.03

            0.63  0.27
m3 (AI) =                0.9
               1 0

                                               0.07
m3 (AI, ND, FC, IBRespi, IBRepro, SHS) =             0.07
                                               1 0

            0.03
m3 (Θ) =          0.03
            1 0


Symptom 3
   Swollen face region is a symptom of Avian Influenza, Newcastle Disease, Fowl Cholera with a bpa of 0.8, so that
m4 {AI, ND, FC} = 0.83
m4 (Θ) = 1 – 0.83= 0.17
We combining symptom 1, symptom 2, and symptom 3 as seen in the table 3.

Table 3 Combination of symptom 1, symptom 2, and symptom 3
                       {AI, ND, FC}                          0.83                       Θ                       0.17
 {AI}                               0.9   {AI}             0.747          {AI}                                0.153
 {AI, ND, FC, IBRespi, IBRepro, 0.07      {AI, ND, FC}     0.0581         {AI, ND, FC, IBRespi, IBRepro,      0.0119
 SHS}                                                                     SHS}
 Θ                                  0.03  {AI, ND, FC}     0.0249         Θ                                   0.0051

            0.747  0.153
m5 (AI) =                  0.9
                1 0

                     0.0581  0.0249
m5 (AI, ND, FC) =                     0.083
                          1 0

m5 (AI, ND, FC, IBRespi, IBRepro, SHS) =
0.0119
         0.0119
 1 0

            0.0051
m5 (Ө) =            0.0051
             1 0



Symptom 4
   Narrowness of eyes is a symptom of Swollen Head Syndrome with a bpa of 0.9, so that:
m6 (SHS) = 0.9
m6 (Θ) = 1 – 0.9 = 0.1
We combining symptom 1, symptom 2, symptom 3 and symptom 4 as seen in the table 4.

Table 4 Combination of symptom 1, symptom 2, symptom 3, and symptom 4
                        {SHS}                            0.9                   Θ                             0.1
 {AI}                              0.9      Θ         0.81       {AI}                                      0.09
 {AI, ND, FC}                      0.083    Θ         0.0747     {AI, ND, FC}                              0.0083
 {AI, ND, FC, IBRespi, IBRepro, 0.0119      {SHS}     0.01071    {AI, ND, FC, IBRespi, IBRepro,            0.00119
 SHS}                                                            SHS}
 Θ                                 0.0051   {SHS}     0.00459    Θ                                         0.00051
0.01071  0.00459
m7 (SHS) =                         0.13270
              1  (0.81  0.0747)

                    0.09
m7 (AI) =                        0.78057
            1  (0.81  0.0747)

                            0.0083
m7 (AI, ND, FC) =                         0.07199
                     1  (0.81  0.0747)

                                                    0.00119
m7 (AI, ND, FC, IBRespi, IBRepro, SHS) =                           0.01032
                                              1  (0.81  0.0747)

                  0.00051
m7 (Θ) =                         0.00442
            1  (0.81  0.0747)



Symptom 5
   Balance disorders is a symptom of Newcastle Diseases and Swollen Head Syndrome with a bpa of 0.6, so that:
m8 {ND,SHS} = 0.6
m8 {Θ} = 1 - 0.6 = 0.4
We combining symptom 1, symptom 2, symptom 3, symptom 4, and symptom 5 as seen in the table 5.

Table 5 Combination of symptom 1, symptom 2, symptom 3, symptom 4, and symptom 5
                        ND, SHS                            0.6                   Θ                          0.4
 {SHS}                          0.13270      {SHS}       0.07962              {SHS}                       0.05308
 {AI}                           0.78057         Θ        0.46834               {AI}                       0.31222
 {AI, ND, FC}                   0.07199       {ND}       0.04319           {AI, ND, FC}                   0.02880
 {AI, ND, FC, IBRespi,          0.01032   {ND, SHS}      0.00619       {AI, ND, FC, IBRespi,              0.00413
 IBRepro, SHS}                                                            IBRepro, SHS}
 Θ                              0.00442   {ND, SHS}      0.00265                 Θ                        0.00177

              0.07962  0.05308
m9 (SHS) =                       0.24960
                 1  0.46834

              0.31222
m9 (AI) =                0.58725
            1  0.46834

               0.04319
m9 (ND) =                 0.08124
             1  0.46834

                   0.00619  0.00265
m9 (ND, SHS) =                        0.01663
                      1  0.46834

                       0.02880
m9 (AI, ND, FC) =                 0.05417
                     1  0.46834

                                                0.00413
m9 (AI, ND, FC, IBRespi, IBRepro, SHS) =                   0.00777
                                              1  0.46834

              0.000232
m9 (Θ) =                  0.00025
            1  0.061038

The most highly bpa value is the m9 (AI) that is equal to 0.58725 which means the possibility of a temporary diseases
with symptoms of depression, comb, wattle, bluish face region, swollen region face, narrowness of eyes, and balance
disorders is the Avian influenza (H5N1). Table 6 and figure 4 – figure 9 shows the basic probability assignment final
result and diseases probability from each condition.

Table 6 Final result
                Diseases                                         Basic Probability Assignment
                                           Condition 1     Condition 2   Condition 3     Condition 4     Condition 5
 Swollen Head Syndrome                        0.25            0.07          0.43            0.61            0.33
 Avian Influenza                              0.59            0.52          0.18            0.06            0.14
 Newcastle Disease                             0.1            0.27          0.25            0.13             0.5
 Newcastle Disease                            0.02            0.02          0.15            0.04             0.5
 Swollen Head Syndrome
 Avian Influenza                               0.05           0.11            0.03           0.04            0.05
 Newcastle Disease
 Fowl Cholera
 Avian Influenza                               0.01           0.02            0.03           0.01           0.005
 Newcastle Disease
 Fowl Cholera
 Infectious Bronchitis respiratory form
 Infectious Bronchitis reproduction
 form
 Swollen Head Syndrome



Figure 4 Diseases probability in condition 1. We get the highest basic probability assignment is AI (Avian Influenza)
        that is equal to 0.55 which show from the last calculation of Dempster-Shafer on symptom 5 which means the
        possibility of a temporary diseases with symptoms of depression, combs, wattle, bluish face region, swollen
        face region, narrowness of eyes, balance disorders is Avian Influenza (H5N1).




Figure 5 Diseases probability in condition 2. we get the highest basic probability assignment is AI (Avian Influenza)
         that is equal to 0.52 which show from the last calculation of Dempster-Shafer on symptom 5 which means the
         possibility of a temporary diseases with symptoms of depression, combs, wattle, bluish face region, swollen
         face region, narrowness of eyes, balance disorders is Avian Influenza (H5N1).
Figure 6 Diseases probability in condition 3. We get the highest basic probability assignment is SHS (Swollen Head
         Syndrome) that is equal to 0.43 which show from the last calculation of Dempster-Shafer on symptom 5
         which means the possibility of a temporary diseases with symptoms of depression, combs, wattle, bluish face
         region, swollen face region, narrowness of eyes, balance disorders is Swollen Head Syndrome.




Figure 7 Diseases probability in condition 4. We get the highest basic probability assignment is SHS (Swollen Head
         Syndrome) that is equal to 0.61 which show from the last calculation of Dempster-Shafer on symptom 5
          which means the possibility of a temporary diseases with symptoms of depression, combs, wattle, bluish face
         region, swollen face region, narrowness of eyes, balance disorders is Swollen Head Syndrome.




Figure 8 Diseases probability in condition 5. We get the highest basic probability assignments are AI (Avian
          Influenza), ND (Newcastle Disease), Fowl Cholera (FC), Infectious Bronchitis respiratory form
          (IBRespi), Infectious Bronchitis reproduction form (IBRepro), and Swollen Head Syndrome (SHS)
         that is equal to 0.9 which show from the last calculation of Dempster-Shafer on symptom 5 which means
         the possibility of a temporary diseases with symptoms of depression, combs, wattle, bluish face region,
         swollen face region, narrowness of eyes, balance disorders are Avian Influenza, Newcastle Disease, Fowl
         Cholera, Infectious Bronchitis respiratory form, Infectious Bronchitis reproduction form, and Swollen
         Head Syndrome.
Figure 9 Diseases probability in each condition. The highest bpa value for condition 1 and condition 2 are Avian
         Influenza diseases, condition 3 and condition 4 are Swollen Head Syndrome diseases, condition 5 is Avian
         Influenza, Newcastle Disease, Fowl Cholera, Infectious Bronchitis respiratory form, Infectious Bronchitis
         reproduction form, and Swollen Head Syndrome. Condition 1, condition 2, condition 4, and condition 5 need
         serious treatment because have basic probability assignment more than 0.5.




4.4 User interface

A user interface is the method by which the expert system interacts with a user. The input or output interface defines the
way in which the expert system interacts with the user and other systems such as databases. Interfaces are graphical
with screen displays, windowing, and mouse control. They receive input from the user and display output to the user
The user interface development of Avian Influenza (H5N1) Expert System to begin with designing web pages and
designing a web-based applications. Designing web pages using PHP, the web page then connected to the MySQL
database, after that designing a web-based applications which used to access the network database. The relationship
between applications with network database has shaped overall applications to manage information to be displayed.
    .

5 Implementation

The following will be shown the working process of expert system in diagnosing a case. The consultation process
begins with selecting the symptoms found on the list of symptoms. In the cases tested, a known symptoms are
depression, comb, wattle, bluish-colored facade region, region of the face swollen, eyes narrowed and balance
disorders. The consultation process and can be seen in Figure 10.

Figure 10 The consultation process
Figure 11 The Result of Consultation. In the case of depression, comb, wattle and region of the face bluish, region of
          the face swollen, eyes narrowed and lachrymal glands swollen. The result of consultation is avian influenza
          (H5N1) with bpa value equal to 0.587275693312.




6 Conclusion

Identification of avian influenza can be performed using Dempster-Shafer Theory. In this paper we describe five
symptoms as major symptoms which include depression, combs, wattle, bluish face region, swollen face region,
narrowness of eyes, and balance disorders. The simplest possible method for using probabilities to quantify the
uncertainty in a database is that of attaching a probability to every member of a relation, and to use these values to
provide the probability that a particular value is the correct answer to a particular query. An expert in providing
knowledge is uncertain in the form of rules with the possibility, the rules are probability value. The knowledge is
uncertain in the collection of basic events can be directly used to draw conclusions in simple cases, however, in many
cases the various events associated with each other. Knowledge based is to draw conclusions, it is derived from
uncertain knowledge. Reasoning under uncertainty that used some of mathematical expressions, gave them a different
interpretation: each piece of evidence (finding) may support a subset containing several hypotheses. This is a
generalization of the pure probabilistic framework in which every finding corresponds to a value of a variable (a single
hypothesis). In this research, Avian Influenza (H5N1) Expert System has been successfully identifying Avian Influenza
diseases and displaying the result of identification process This research can be an alternative in addition to direct
consultation with doctor and to find out quickly avian influenza (H5N1) disease.


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Avian Influenza (H5N1) Expert System using Dempster-Shafer Theory

  • 1. Avian Influenza (H5N1) Expert System using Dempster-Shafer Theory Andino Maseleno Department of Computer Science, Faculty of Science, Universiti Brunei Darussalam Jalan Tungku Link, Gadong BE 1410, Negara Brunei Darussalam E-mail: andinomaseleno@yahoo.com Md. Mahmud Hasan Department of Computer Science, Faculty of Science, Universiti Brunei Darussalam Jalan Tungku Link, Gadong BE 1410, Negara Brunei Darussalam mahmud.hasan@ubd.edu.bn Abstract: Based on Cumulative Number of Confirmed Human Cases of Avian Influenza (H5N1) Reported to World Health Organization (WHO) in the 2011 from 15 countries, Indonesia has the largest number death because Avian Influenza which 146 deaths. In this research, the researcher built an Avian Influenza (H5N1) Expert System for identifying avian influenza disease and displaying the result of identification process. In this paper, we describe five symptoms as major symptoms which include depression, combs, wattle, bluish face region, swollen face region, narrowness of eyes, and balance disorders. We use chicken as research object. Dempster-Shafer theory to quantify the degree of belief as inference engine in expert system, our approach uses Dempster-Shafer theory to combine beliefs under conditions of uncertainty and ignorance, and allows quantitative measurement of the belief and plausibility in our identification result. The result reveal that Avian Influenza (H5N1) Expert System has successfully identified the existence of avian influenza and displaying the result of identification process. Keywords: avian influenza (H5N1), expert system, uncertainty, dempster-shafer theory eference to this paper should be made as follows: Maseleno, A. and Mahmud Hasan, Md. (2012) ‘Avian Influenza (H5N1) Expert System using Dempster-Shafer Theory’, Int. J. Information and Communication Technology, Vol. 4, No. 2 Biographical notes: Andino Maseleno is a Ph.D. student in the Department of Computer Science, University Brunei Darussalam. His research interest is in the area of artificial intelligence. He receive Graduate Research Scholarship (GRS) from Duli Yang Maha Mulia Sultan Haji Hassanal Bolkiah. Dr. Md. Mahmud Hasan is a Senior Lecturer in the Deptartment of Computer Science, University Brunei Darussalam. His research interest is in the areas of Internet Appliances, artificial intelligence and embedded system. He has 35 publications in the international and national journal/conferences/book chapters. Also hold a patent over the “Internet appliance for ECG”. 1 Introduction Historically, outbreaks of avian influenza first occurred in Italy in the 1878, when it was a lot of dead birds [1]. Then came another outbreak of Avian Influenza in Scotland in the 1959 [2]. The virus that causes Avian Influenza in Italy and Scotland are the current strain of H5N1 virus appeared again attacked poultry and humans in various countries in Asia, including Indonesia, which caused many deaths in humans [3]. Avian influenza virus H5N1, which has been limited to poultry, now has spread to migrating birds and has emerged in mammals and among the human population. It presents a distinct threat of a pandemic for which the World Health Organization and other organizations are making preparations. In the 2005, the World Health Assembly urged its Member States to develop national preparedness plans for pandemic influenza [4]. Developing countries face particular planning and other challenges with pandemic preparedness as there may be a higher death rate in developing countries compared with more developed countries [5].
  • 2. Expert System is a computer application of artificial intelligence [6],[8],[9] which contains a knowledge base and an inference engine [7]. Since such programs attempt to emulate the thinking patterns of an expert, it is natural that the first work was done in artificial intelligence circles. Among the first expert systems were the 1965 Dendral programs [10], which determined molecular structure from mass spectrometer data; R1 [11] used to configure computer systems; and MYCIN [12] for medical diagnosis. The basic idea behind expert system is simply that expertise, which is the vast body of task-specific knowledge, is transferred from a human to a computer. This knowledge is then stored in the computer and users call upon the computer for specific advice as needed. The computer can make inferences and arrive at a specific conclusion. Then like a human consultant, it gives advices and explains, if necessary, the logic behind the advice [13]. Some expert systems for diagnosis in avian influenza have been developed which were expert system for avian influenza disease using Visual Basic.NET [14], and web based [15]. Actually, according to researchers knowledge, Dempster-Shafer theory of evidence has never been used for built an expert system for identifying avian influenza. The remainder is organized as follows. The uncertainty in expert system is briefly reviewed in Section 2. Section 3 details the proposed Dempster-Shafer Theory. Architecture of Avian Influenza (H5N1) Expert System in Section 4. The experimental results are presented in Section 5, and final remarks are concluded in Section 6. 2 Uncertainty in Expert System The construction of expert and other intelligent computer systems requires sophisticated mechanism for representing and reasoning with uncertain information. At least three forms of uncertainty can be identified as playing a significant role in these types of systems. The first of these possibilistic uncertainty appears in situations where the value of a variable can only be narrowed down to a set of values one of which is the actual value of the variable. The second kind of uncertainty is related to situations in which there exists uncertainty as to satisfaction of a predicate by an element. This is manifested by concepts which have imprecise or gray boundaries. A very powerful tool for handling this type of uncertainty which also handles the first type of uncertainty is the fuzzy set. The third type of uncertainty is related to situations in which the value of a variable assumes can be modeled by the performance of a random experiment [16]. Figure 1 shows the process for dealing with uncertainty in Avian Influenza (H5N1) Expert System. Figure 1 The process for dealing with uncertainty in Avian Influenza (H5N1) Expert System Step 1 Representation of uncertainty Alternative Rule on the set of basic events Step 2 Step 3 Merging uncertain information Conclusion In step 1, an expert provides uncertain knowledge in the form of rules with the possibility. These rules are probability values. In step 2, the uncertain knowledge on a set of basic events can be directly used to draw conclusions in simple cases (step 3). However, in many cases the various events associated with each other. Therefore, it is necessary to combine the information contained in step 1 into the global value system. In step 3, the goal is knowledge- based systems draw conclusions. It is derived from uncertain knowledge in steps 1 and 2, and is usually implemented by an inference engine. Working with the inference engine, the expert can adjust the input that they enter in step 1 after displaying the results in step 2 and step 3.
  • 3. 3 Dempster-Shafer Theory The Dempster-Shafer theory was first introduced by Dempster [17] and then extended by shafer [18], but the kind of reasoning the theory uses can be found as far back as the seventeenth century. This theory is actually an extension to classic probabilistic uncertainty modeling. Whereas the Bayesian theory requires probabilities for each question of interest, belief functions allow us to base degrees of belief for on question on probabilities for a related question. The advantages of the Dempster-Shafer theory as follows: 1. It has the ability to model information in a flexible way without requiring a probability to be assigned to each element in a set, 2. It provides a convenient and simple mechanism (Dempster's combination rule) for combining two or more pieces of evidence under certain conditions. 3. It can model ignorance explicitly. 4. Rejection of the law of additivity for belief in disjoint propositions. Avian Influenza (H5N1) Expert System using Dempster-Shafer theory in the decision support process. Flowchart of Avian Influenza (H5N1) Expert System shown in Figure 2. Figure 2 Flowchart of Avian Influenza (H5N1) Expert System Start Yes Input Symptoms m1 (B) m2 (C) No m (A) = 1 End The consultation process begins with selecting the symptoms. If there are symptoms then will calculate, The Dempster- Shafer theory provides a rule to combine evidences from independent observers and into a single and more informative hint. Evidence theory is based on belief function and plausible reasoning. First of all, we must define a frame of discernment, indicated by the sign Θ . The sign 2Θ indicates the set composed of all the subset generated by the frame of discernment. For a hypothesis set, denoted by A, m(A)→[0,1]. m( )=0 (1) is the sign of an empty set. The function m is the basic probability assignment. Dempster's rule of combination combines two independent sets of mass assignments. ( )=0 (2) (3) Where (4) [ ]
  • 4. The results reveal that Avian Influenza (H5N1) Expert System successfully identifying disease and displaying the result of identification process. 4 Avian Influenza (H5N1) Expert System Avian Influenza (H5N1) Expert System has four main architectural components that are the knowledge base, the inference engine, the knowledge acquisition module, and the user interface for input/output. Figure 3 shows architecture of Avian Influenza (H5N1) Expert System. Figure 3 Architecture of Avian Influenza (H5N1) Expert System Knowledge Acquisition Knowledge Base Inference Engine User Interface 4.1 Knowledge acquisition In the present work, knowledge has been obtained from two sources. We acquired textual information from literature such as extension booklets, reports, papers, etc., related to the avian influenza diseases. The printed material allowed became familiar with the subject and a more effective communication with the experts. Most knowledge was acquired from the experts using conventional interviewing techniques. The interview methods permitted a better understanding of the problem and its further representation. This knowledge was provided by experts on avian influenza. Unstructured and structured interviews were used. The unstructured interviews were used to define the familiar tasks involved in the process of identification, to obtain an initial understanding of the range of complications involved, and to define specific problems for later discussion. The questions were more or less spontaneous and notes were taken on discussion. These methods were complemented with structured interviews. In the structured interviews, we revised and discussed in depth familiar tasks to clarify questions. 4.2 Knowledge base A critical aspect of building an expert system is formulating the scope of the problem and gleaning from the source expert the domain information needed to solve the problem. The reliability of an expert system depends on the quality of knowledge contained in the knowledge base. In this research, we built a Avian Influenza (H5N1) Expert System and we describe five symptoms which include depression, combs, wattle, bluish face region, swollen face region, narrowness of eyes, and balance disorders. Knowledge of which input on the testing of this expert system can be seen in table 1. Supposed we have five different conditions.
  • 5. Table 1 Knowledge base Symptom Disease Basic Probability Assignment Condition Condition Condition Condition Condition 1 2 3 4 5 Depression Avian Influenza 0.7 0.9 0.8 0.9 0.6 Newcastle Disease Fowl Cholera Infectious Bronchitis Respiratory Form Infectious Bronchitis Reproduction Form Swollen Head Syndrome Combs, Wattle, Bluish Avian Influenza 0.9 0.8 0.9 0.6 0.7 Face Region Swollen Face Region Avian Influenza 0.83 0.9 0.6 0.7 0.9 Newcastle Disease Fowl Cholera Narrowness of Eyes Swollen Head 0.9 0.6 0.7 0.9 0.8 Syndrome Balance Disorders Newcastle Diseases 0.6 0.7 0.9 0.8 0.9 Swollen Head Syndrome 4.3 Inference Engine The inference engine is charged with the role of performing and controlling inference on the knowledge base. Specific features of the inference engine depend on the knowledge representation scheme used for the knowledge base. Because the most common representation scheme is production rules, this inference engine will be exemplified. In this research we use forward chaining inference engine using Dempster-Shafer Theory. The following will be shown the inference engine using Dempster-Shafer Theory to diagnose avian influenza in condition 1. Symptoms: 1. Depression 2. Combs, wattle, bluish face region 3. Swollen face region 4. Narrowness of eyes 5. Balance disorder Symptom 1 Depression is a symptom of Avian Influenza (AI), Newcastle Disease (ND), Fowl Cholera (FC), Infectious Bronchitis respiratory form (IBRespi), Infectious Bronchitis reproduction form (IBRepro), and Swollen Head Syndrome (SHS). The measures of uncertainty, taken collectively are known in Dempster-Shafer Theory terminology as a ``basic probability assignment'' (bpa). Hence we have a bpa, say m1 of 0.7 given to the focal element {AI, ND, FC, IBRespi, IBRepro, SHS} in example, m1({AI, ND, FC, IBRespi, IBRepro, SHS}) = 0.7, since we know nothing about the remaining probability it is allocated to the whole of the frame of the discernment in example, m1({AI, ND, FC, IBRespi, IBRepro, SHS}) = 0.3, so: m1{AI, ND, FC, IBRespi, IBRepro, SHS} = 0.7 m1{Θ} = 1 - 0.7 = 0.3 Symptom 2 Combs, wattle, bluish face region are symptoms of Avian Influenza with a bpa of 0.9, so that: m2{AI} = 0.9 m2 {Θ} = 1 – 0.9 = 0.1 We combining symptom 1, and symptom 2 as seen in the table 2.
  • 6. Table 2 Combination of symptom 1, and symptom 2 {AI} 0.9 Θ 0.1 {AI, ND, FC, IBRespi, IBRepro, SHS} 0.7 {AI} 0.63 {AI, ND, FC, IBRespi, IBRepro, SHS} 0.07 Θ 0.3 {AI} 0.27 Θ 0.03 0.63  0.27 m3 (AI) =  0.9 1 0 0.07 m3 (AI, ND, FC, IBRespi, IBRepro, SHS) =  0.07 1 0 0.03 m3 (Θ) =  0.03 1 0 Symptom 3 Swollen face region is a symptom of Avian Influenza, Newcastle Disease, Fowl Cholera with a bpa of 0.8, so that m4 {AI, ND, FC} = 0.83 m4 (Θ) = 1 – 0.83= 0.17 We combining symptom 1, symptom 2, and symptom 3 as seen in the table 3. Table 3 Combination of symptom 1, symptom 2, and symptom 3 {AI, ND, FC} 0.83 Θ 0.17 {AI} 0.9 {AI} 0.747 {AI} 0.153 {AI, ND, FC, IBRespi, IBRepro, 0.07 {AI, ND, FC} 0.0581 {AI, ND, FC, IBRespi, IBRepro, 0.0119 SHS} SHS} Θ 0.03 {AI, ND, FC} 0.0249 Θ 0.0051 0.747  0.153 m5 (AI) =  0.9 1 0 0.0581  0.0249 m5 (AI, ND, FC) =  0.083 1 0 m5 (AI, ND, FC, IBRespi, IBRepro, SHS) = 0.0119  0.0119 1 0 0.0051 m5 (Ө) =  0.0051 1 0 Symptom 4 Narrowness of eyes is a symptom of Swollen Head Syndrome with a bpa of 0.9, so that: m6 (SHS) = 0.9 m6 (Θ) = 1 – 0.9 = 0.1 We combining symptom 1, symptom 2, symptom 3 and symptom 4 as seen in the table 4. Table 4 Combination of symptom 1, symptom 2, symptom 3, and symptom 4 {SHS} 0.9 Θ 0.1 {AI} 0.9 Θ 0.81 {AI} 0.09 {AI, ND, FC} 0.083 Θ 0.0747 {AI, ND, FC} 0.0083 {AI, ND, FC, IBRespi, IBRepro, 0.0119 {SHS} 0.01071 {AI, ND, FC, IBRespi, IBRepro, 0.00119 SHS} SHS} Θ 0.0051 {SHS} 0.00459 Θ 0.00051
  • 7. 0.01071  0.00459 m7 (SHS) =  0.13270 1  (0.81  0.0747) 0.09 m7 (AI) =  0.78057 1  (0.81  0.0747) 0.0083 m7 (AI, ND, FC) =  0.07199 1  (0.81  0.0747) 0.00119 m7 (AI, ND, FC, IBRespi, IBRepro, SHS) =  0.01032 1  (0.81  0.0747) 0.00051 m7 (Θ) =  0.00442 1  (0.81  0.0747) Symptom 5 Balance disorders is a symptom of Newcastle Diseases and Swollen Head Syndrome with a bpa of 0.6, so that: m8 {ND,SHS} = 0.6 m8 {Θ} = 1 - 0.6 = 0.4 We combining symptom 1, symptom 2, symptom 3, symptom 4, and symptom 5 as seen in the table 5. Table 5 Combination of symptom 1, symptom 2, symptom 3, symptom 4, and symptom 5 ND, SHS 0.6 Θ 0.4 {SHS} 0.13270 {SHS} 0.07962 {SHS} 0.05308 {AI} 0.78057 Θ 0.46834 {AI} 0.31222 {AI, ND, FC} 0.07199 {ND} 0.04319 {AI, ND, FC} 0.02880 {AI, ND, FC, IBRespi, 0.01032 {ND, SHS} 0.00619 {AI, ND, FC, IBRespi, 0.00413 IBRepro, SHS} IBRepro, SHS} Θ 0.00442 {ND, SHS} 0.00265 Θ 0.00177 0.07962  0.05308 m9 (SHS) =  0.24960 1  0.46834 0.31222 m9 (AI) =  0.58725 1  0.46834 0.04319 m9 (ND) =  0.08124 1  0.46834 0.00619  0.00265 m9 (ND, SHS) =  0.01663 1  0.46834 0.02880 m9 (AI, ND, FC) =  0.05417 1  0.46834 0.00413 m9 (AI, ND, FC, IBRespi, IBRepro, SHS) =  0.00777 1  0.46834 0.000232 m9 (Θ) =  0.00025 1  0.061038 The most highly bpa value is the m9 (AI) that is equal to 0.58725 which means the possibility of a temporary diseases with symptoms of depression, comb, wattle, bluish face region, swollen region face, narrowness of eyes, and balance
  • 8. disorders is the Avian influenza (H5N1). Table 6 and figure 4 – figure 9 shows the basic probability assignment final result and diseases probability from each condition. Table 6 Final result Diseases Basic Probability Assignment Condition 1 Condition 2 Condition 3 Condition 4 Condition 5 Swollen Head Syndrome 0.25 0.07 0.43 0.61 0.33 Avian Influenza 0.59 0.52 0.18 0.06 0.14 Newcastle Disease 0.1 0.27 0.25 0.13 0.5 Newcastle Disease 0.02 0.02 0.15 0.04 0.5 Swollen Head Syndrome Avian Influenza 0.05 0.11 0.03 0.04 0.05 Newcastle Disease Fowl Cholera Avian Influenza 0.01 0.02 0.03 0.01 0.005 Newcastle Disease Fowl Cholera Infectious Bronchitis respiratory form Infectious Bronchitis reproduction form Swollen Head Syndrome Figure 4 Diseases probability in condition 1. We get the highest basic probability assignment is AI (Avian Influenza) that is equal to 0.55 which show from the last calculation of Dempster-Shafer on symptom 5 which means the possibility of a temporary diseases with symptoms of depression, combs, wattle, bluish face region, swollen face region, narrowness of eyes, balance disorders is Avian Influenza (H5N1). Figure 5 Diseases probability in condition 2. we get the highest basic probability assignment is AI (Avian Influenza) that is equal to 0.52 which show from the last calculation of Dempster-Shafer on symptom 5 which means the possibility of a temporary diseases with symptoms of depression, combs, wattle, bluish face region, swollen face region, narrowness of eyes, balance disorders is Avian Influenza (H5N1).
  • 9. Figure 6 Diseases probability in condition 3. We get the highest basic probability assignment is SHS (Swollen Head Syndrome) that is equal to 0.43 which show from the last calculation of Dempster-Shafer on symptom 5 which means the possibility of a temporary diseases with symptoms of depression, combs, wattle, bluish face region, swollen face region, narrowness of eyes, balance disorders is Swollen Head Syndrome. Figure 7 Diseases probability in condition 4. We get the highest basic probability assignment is SHS (Swollen Head Syndrome) that is equal to 0.61 which show from the last calculation of Dempster-Shafer on symptom 5 which means the possibility of a temporary diseases with symptoms of depression, combs, wattle, bluish face region, swollen face region, narrowness of eyes, balance disorders is Swollen Head Syndrome. Figure 8 Diseases probability in condition 5. We get the highest basic probability assignments are AI (Avian Influenza), ND (Newcastle Disease), Fowl Cholera (FC), Infectious Bronchitis respiratory form (IBRespi), Infectious Bronchitis reproduction form (IBRepro), and Swollen Head Syndrome (SHS) that is equal to 0.9 which show from the last calculation of Dempster-Shafer on symptom 5 which means the possibility of a temporary diseases with symptoms of depression, combs, wattle, bluish face region, swollen face region, narrowness of eyes, balance disorders are Avian Influenza, Newcastle Disease, Fowl Cholera, Infectious Bronchitis respiratory form, Infectious Bronchitis reproduction form, and Swollen Head Syndrome.
  • 10. Figure 9 Diseases probability in each condition. The highest bpa value for condition 1 and condition 2 are Avian Influenza diseases, condition 3 and condition 4 are Swollen Head Syndrome diseases, condition 5 is Avian Influenza, Newcastle Disease, Fowl Cholera, Infectious Bronchitis respiratory form, Infectious Bronchitis reproduction form, and Swollen Head Syndrome. Condition 1, condition 2, condition 4, and condition 5 need serious treatment because have basic probability assignment more than 0.5. 4.4 User interface A user interface is the method by which the expert system interacts with a user. The input or output interface defines the way in which the expert system interacts with the user and other systems such as databases. Interfaces are graphical with screen displays, windowing, and mouse control. They receive input from the user and display output to the user The user interface development of Avian Influenza (H5N1) Expert System to begin with designing web pages and designing a web-based applications. Designing web pages using PHP, the web page then connected to the MySQL database, after that designing a web-based applications which used to access the network database. The relationship between applications with network database has shaped overall applications to manage information to be displayed. . 5 Implementation The following will be shown the working process of expert system in diagnosing a case. The consultation process begins with selecting the symptoms found on the list of symptoms. In the cases tested, a known symptoms are depression, comb, wattle, bluish-colored facade region, region of the face swollen, eyes narrowed and balance disorders. The consultation process and can be seen in Figure 10. Figure 10 The consultation process
  • 11. Figure 11 The Result of Consultation. In the case of depression, comb, wattle and region of the face bluish, region of the face swollen, eyes narrowed and lachrymal glands swollen. The result of consultation is avian influenza (H5N1) with bpa value equal to 0.587275693312. 6 Conclusion Identification of avian influenza can be performed using Dempster-Shafer Theory. In this paper we describe five symptoms as major symptoms which include depression, combs, wattle, bluish face region, swollen face region, narrowness of eyes, and balance disorders. The simplest possible method for using probabilities to quantify the uncertainty in a database is that of attaching a probability to every member of a relation, and to use these values to provide the probability that a particular value is the correct answer to a particular query. An expert in providing knowledge is uncertain in the form of rules with the possibility, the rules are probability value. The knowledge is uncertain in the collection of basic events can be directly used to draw conclusions in simple cases, however, in many cases the various events associated with each other. Knowledge based is to draw conclusions, it is derived from uncertain knowledge. Reasoning under uncertainty that used some of mathematical expressions, gave them a different interpretation: each piece of evidence (finding) may support a subset containing several hypotheses. This is a generalization of the pure probabilistic framework in which every finding corresponds to a value of a variable (a single hypothesis). In this research, Avian Influenza (H5N1) Expert System has been successfully identifying Avian Influenza diseases and displaying the result of identification process This research can be an alternative in addition to direct consultation with doctor and to find out quickly avian influenza (H5N1) disease. References [1]. B. L. Ligon, Avian Influenza Virus H5N1: “A Review of Its History and Information Regarding Its Potential to Cause the Next Pandemic,” Seminars in Pediatric Infectious Diseases, Elsevier, pp. 326 – 335, 2005. [2]. A. S. Fauci, “Emerging and Re-Emerging Infectious Diseases: Influenza as a Prototype of the Host-Pathogen Balancing Act,” Elsevier, Cell, pp. 665 -670, 2006. [3]. L. D Sims, J. Domenech, C. Benigno, S. Kahn, A. Kamata, J. Lubrouth, V. Martin, and P. Roeder, “Origin and evolution of highly pathogenic H5N1 avian influenza in Asia,” The Veterinary Record, pp. 159 – 164, 2006. [4]. W. H. Assembly, “Strengthening pandemic-influenza preparedness and response,” Resolution WHA58.5, 2005. [5]. E. Azziz-Baumgartner, N. Smith, R. González-Alvarez, “National pandemic influenza preparedness planning,” Influenza and Other Respiratory Viruses, pp. 189 – 196, 2006. [6]. J. Durkin, Expert system: Catalog of applications: Intelligent Computer Systems, Inc., Akron, OH. First Edition, 1993. [7]. J. Durkin, Expert Systems: Design and Development, Prentice Hall, Englewood Cliffs, N.J., 1994.
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