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1. Drugs containing Carboxylic acid

2. Introduction are organic acids characterized by the presence of at least one carboxyl group. The general formula of a carboxylic acid is R-COOH

4. Examples for carboxylic acids included in some drug : 1. Salicylic acid. 2.Fusidic acid. 3. Citric acid. 4. Ascorbic acid. 5. Benzoic acid. 6.Lactic acid. 7.Tartaric acid.

6. Aspirin For Example: 1- Aspocid. ( shewable tablets) 2- Rivo( tablets) 3- Rivoped( supp) 4- aspocid buffer( eff) 5-Aspegic( vial) It is Acetyl salicylic acid which have many trade names in the Egyptian market

7. synthesis

9. 1- headache. ( the 1st drug in treatment of migraine) 2- pain( muscle, cramps ,skin irritation) 3-prevention of heart attacks and strokes . 4-for fever and pains associated with common cold 5-for joint pain of acute rheumatic fever Indications

10. Side Effects :

11. Contraindications : 1-Hypersensitivity to salicylates 2-Clients with asthma, hay fever 3- Severe anemia 4- history of blood coagulation defects, 5-in conjunction with anticoagulant therapy 6-In pregnancy, especially the last trimester as the drug may cause problems in the newborn child or complications during delivery.

12. 1-Use with caution during lactation. 2-gastric or peptic ulcers, 3- in cardiac disease. 4- in liver or kidney disease. Precautions

13. Heel Forte ointment Composition; Salicylic acid 12 g Urea 8 g Dose: A thin film of the ointment should be applied twice daily to cover the affected area completely

14. PROPERTIES : Salicylic acid has keratolyticproperty which causes the cornified tissues to swell, soften, macerate and desquamate. Urea moisturizes and softens severely dry, rough skin SO INDICATIONS : 1-Removal of callus and corns 2-Smoothing of intensely rough heels 3-Helps in treatment of warts

16. Examples for soaps containing carboxylic acids

18. Fawar Fruit

19. PRESENTATION FORM : Sachet COMPOSITION: Citric acid 16 gm Flavor and color to 100 gm Sodium bicarbonate 56 gm Tartaric acid 26.7 gm USES: Antacids in the gastrointestinal system .

20. Eva Spotless Cream

22. Cream gently removes the top layer of dead cells and cleans pores, preventing problems.

24. Structure:

25. Fusiderm ointment

26. Components: Each 100 gmFusidermointment contains Sodium fusidate2 gm USES: Fusidermis an antibiotic having a potent antimicrobial activity against many Gram-positive organisms such as, Streptococci, Corynebacteriumminutissimum and particularly Staphylococci, including the strains resistant to penicillin or other antibiotics. Fusiderm provides highly effective topical treatment in primary and secondary bacterial infections of the skin and has a unique ability to penetrate intact skin

27. Betafucin cream

28. COMPOSITION: Each gram contains : Fucidicacid 20 mg Betamethasone 1mg PROPERTIES: Betafucincream combines the potent topical antibacterial action of fusidic acid with the anti-inflammatory and antipruritic effect of betamethasone

29. VITACID C

30. Are effervescent granules of single vitamin ( ascorbic acid) COMPOSITION : 1- sachets: each 4 gm sachet contain 500 mg ascorbic acid 2- 1 gm effervescent tablets contain 1 gm ascorbic acid

31. VITAMIN C PROPERTIES: 1-Vitamin C is an essential co-enzyme for collagen formation 2-tissue repair and synthesis of lipids and proteins. 3-It acts both as a reducing agent and as antioxidant. 4-It is necessary for many physiologic functions e.g. metabolism of iron, carbohydrate and folic acid, resistance to infection, cellular respiration and preservation of blood vessel integrity.

32. 1-Prevention and treatment of scurvy. 2-Symptomatic relief of common cold and influenza 3-Pregnancy and lactation. 4-in certain diseases and conditions such as: hyperthyroidism, peptic ulcer, chronic illness and infections (whooping cough, pneumonia, sinusitis and rheumatic fever). History of hyper sensitivity to vitamin C

33. REFERENCES: 1- Organic chemistry (5th Edition), Paula YurkanisBruice . 2-2nd Edition Therapeutic drugs , Colin Dollergy , Vol 1. 3- 2nd Edition therapeutic drugs, Colin Dollergy, vol2. 4-Drug Index , Master on therapeutic Drugs , Dr. HeneinWely & Dr. UsamaTharwat. 5- Mina El Bostany pharmacy .

34. BY: 1- Aya Ahmed Saber 2- GehanEssamMahmood 3- EmanAlaa El Shamy 4-Eman Mohamed Mostafa Faculty of pharmacy ASU Pharmaceutical Chemistry department 1st Year Section 2