1. Technical Presentation
Introducing
DuPont™ Verimark™ and Exirel™
New Insect Control Products
for Pest Management and Optimizing Yield
in FL Citrus
DuPont™ Cyazypyr™, Verimark™, Exirel™ and Benevia™ are not registered for sale
or use in the United States. No offer for sale, sale or use of these products are permitted
prior to the issuance of the required EPA and state registrations. Anticipated EPA
Federal Registration is first calendar quarter 2013.
2. Grower Benefits of
Products powered by Cyazypyr™
DuPont™ Cyazypyr™ helps improve early crop establishment for
visibly vigorous plants from start to finish, to help growers produce a
stronger crop in the field for a more appealing crop at harvest.
• Applications early in the crop cycle protect tender
seedlings from feeding damage and transmission of
some pest-vectored diseases
• Reducing biotic stresses improves crop establishment
and gets the crop off to a strong start
• Getting the crop off to a strong start with a program
including Cyazypyr™ consistently creates an opportunity
for improved yield at harvest
DuPont™ Benevia™, Exirel™, Verimark™ and Cyazypyr™ are not registered for sale or use in the United States. No offer for sale, sale or use of these products are permitted
prior to the issuance of the required EPA and state registrations. Anticipated EPA Federal Registration is first calendar quarter 2013.
3. Designed for Optimal Performance
Products powered by Cyazypyr™
Verimark™ is designed for soil applications
• For optimized root uptake and crop safety to tender roots and
shoots, protecting both older leaves and new growth from a
cross-spectrum of pests and helping provide consistently better
yield and quality results at harvest.
Exirel™ and Benevia™ are designed for foliar applications
• For optimized leaf penetration and locally systemic movement,
improving coverage and protection from a cross-spectrum of
pests and potentially improving a plant’s resilience to stress.
DuPont™ Benevia™, Exirel™, Verimark™ and Cyazypyr™ are not registered for sale or use in the United States. No offer for sale, sale or use of these products are permitted
prior to the issuance of the required EPA and state registrations. Anticipated EPA Federal Registration is first calendar quarter 2013.
4. What is Cyazypyr™?
The second active ingredient in the anthranilic diamide class
and the first to control a cross-spectrum of chewing and sucking pests
whiteflies aphids
Source: DuPont, USA Source: DuPont, USA
leafminers Cyazypyr™ thrips
(cyantraniliprole)
Source: DuPont, The Netherlands Source: DuPont,
Spain
fruit flies Leps
beetles weevils hoppers psyllids
Source: DuPont, France
Source: http://www.ars.usda.gov/is/
graphics/photos/mar09/d1032-1.jpg
Source: Source: Sylvia Villareal/IRRI Source: DuPont, Poland
Source: DuPont, Poland Source: http://gardening-
http://www.fotosearch.com coaches.com/CommunityGarden/gardening/asian
-citrus-psyllid-reaches-ventura-county/
DuPont™ Benevia™, Exirel™, Verimark™ and Cyazypyr™ are not registered for sale or use in the United States. No offer for sale, sale or use of these products are permitted
prior to the issuance of the required EPA and state registrations. Anticipated EPA Federal Registration is first calendar quarter 2013.
5. Crop Uses Targeted in the US
Products powered by Cyazypyr™
Products powered by Cyazypyr™
are effective on a wide range of crops*
OR
• Fruiting vegetables • Bulb vegetables • Fruiting vegetables
• Cucurbits • Cotton • Cucurbits
• Brassica • Potatoes • Brassica
• Leafy vegetables • Oil seed crops • Leafy vegetables
• Bulb vegetables • Tuberous & corm vegetables
• Citrus
• Including potatoes
• Pome fruit
• Citrus (small trees)
• Stone fruit
• Bushberries
• Tree nuts
* Not all crops are listed. Consult your local label.
DuPont™ Benevia™, Exirel™, Verimark™ and Cyazypyr™ are not registered for sale or use in the United States. No offer for sale, sale or use of these products are permitted
prior to the issuance of the required EPA and state registrations. Anticipated EPA Federal Registration is first calendar quarter 2013.
6. Uniqueness of
Products powered by Cyazypyr™
DuPont™ Cyazypyr™ insect control
features a unique combination of product attributes
Cyazypyr™ Feature Product Attribute
Cross-spectrum Controls mixed pest populations
Fast-acting Protects crops from feed damage and transmission of some diseases
Translaminar Rainfastness and improved availability of Cyazypyr™ to different kinds of pests
Root systemic Controls foliar pests when applied to the roots
New MOA for sucking pests Controls pests resistant to other MOAs
Selective for beneficial arthropods Strong fit in IPM programs; non-disruptive
Low mammalian toxicity Convenient to use
Excellent environmental profile Sustainable use
DuPont™ Benevia™, Exirel™, Verimark™ and Cyazypyr™ are not registered for sale or use in the United States. No offer for sale, sale or use of these products are permitted
prior to the issuance of the required EPA and state registrations. Anticipated EPA Federal Registration is first calendar quarter 2013.
7. Mode of Action of Cyazypyr™:
The basis for rapid feeding cessation and plant protection
Muscle Muscle
fiber fibril
RyR
Muscle Depleted
Internal
Ca++ store
Internal
Ca++ store
SYMPTOMS OF INSECT TOXICITY
• Rapid feeding cessation
Cyazypyr™ impacts insect behavior • General lethargy
by impairing muscle function • Paralysis
• Regurgitation (Lep larvae)
• Eventual pest mortality
Source: DuPont Stine-Haskell Research Center, Delaware, USA (2009)
DuPont™ Benevia™, Exirel™, Verimark™ and Cyazypyr™ are not registered for sale or use in the United States. No offer for sale, sale or use of these products are permitted
prior to the issuance of the required EPA and state registrations. Anticipated EPA Federal Registration is first calendar quarter 2013.
8. Cyazypyr™ — Receptor Selectivity
Excellent Mammalian Toxicological Profile
As a Result of Selective Affinity for Insect Ryanodine Receptors (RyR)
No response was
observed in the
human cell line
DuPont™ Benevia™, Exirel™, Verimark™ and Cyazypyr™ are not registered for sale or use in the United States. No offer for sale, sale or use of these products are permitted
prior to the issuance of the required EPA and state registrations. Anticipated EPA Federal Registration is first calendar quarter 2013.
9. Cyazypyr™ — Mammalian Toxicology
Excellent Mammalian Toxicological Profile
All regulatory toxicology
studies have shown low
toxicity to mammals.
DuPont™ Benevia™, Exirel™, Verimark™ and Cyazypyr™ are not registered for sale or use in the United States. No offer for sale, sale or use of these products are permitted
prior to the issuance of the required EPA and state registrations. Anticipated EPA Federal Registration is first calendar quarter 2013.
10. Acute Toxicity of Cyazypyr™ Products
vs. Other Insecticides
The excellent mammalian toxicological profile of Cyazypyr™
is comparable to the best available in the marketplace.
DuPont™ Benevia™, Exirel™, Verimark™ and Cyazypyr™ are not registered for sale or use in the United States. No offer for sale, sale or use of these products are permitted
prior to the issuance of the required EPA and state registrations. Anticipated EPA Federal Registration is first calendar quarter 2013.
11. Cyazypyr™ Selectivity to Beneficial
Arthropods
Non-disruptive -
Cyazypyr™ has moderate to no impact
on pollinators, parasitoids and predators
DuPont™ Benevia™, Exirel™, Verimark™ and Cyazypyr™ are not registered for sale or use in the United States. No offer for sale, sale or use of these products are permitted
prior to the issuance of the required EPA and state registrations. Anticipated EPA Federal Registration is first calendar quarter 2013.
12. DuPont™ Benevia™, Exirel™, Verimark™ and Cyazypyr™ are not registered for sale or use in the United States. No offer for sale, sale or use of these products are permitted
prior to the issuance of the required EPA and state registrations. Anticipated EPA Federal Registration is first calendar quarter 2013.
13. Crops Covered
DuPont™ Benevia™, Exirel™, Verimark™ and Cyazypyr™ are not registered for sale or use in the United States. No offer for sale, sale or use of these products are permitted
prior to the issuance of the required EPA and state registrations. Anticipated EPA Federal Registration is first calendar quarter 2013.
14. US Registration
Anticipated Timeline Summary
Initial EPA Submission
(OECD dossier for Global Joint Review)
•Submission to EPA
• Jun 29, 2011
•Anticipated EPA approval
• 1st quarter 2013
•Anticipated FL approval
• 2nd quarter 2013
•State approvals
• Most within 90 days of submission following EPA approval
DuPont™ Benevia™, Exirel™, Verimark™ and Cyazypyr™ are not registered for sale or use in the United States. No offer for sale, sale or use of these products are permitted
prior to the issuance of the required EPA and state registrations. Anticipated EPA Federal Registration is first calendar quarter 2013.
15. Summary:
DuPont™ Cyazypyr™ improves early crop establishment for visibly
vigorous plants from start to finish, to help growers produce a
stronger crop in the field for a more appealing crop at harvest.
DuPont™ Benevia™, Exirel™, Verimark™ and Cyazypyr™ are not registered for sale or use in the United States. No offer for sale, sale or use of these products are permitted
prior to the issuance of the required EPA and state registrations. Anticipated EPA Federal Registration is first calendar quarter 2013.
