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Slide 2




© Copyright Objective Insights, Inc. All   www.ObjectiveInsights.com
Rights Reserved
Slide 3




© Copyright Objective Insights, Inc. All   www.ObjectiveInsights.com
Rights Reserved
Background                                                             Slide 4




© Copyright Objective Insights, Inc. All   www.ObjectiveInsights.com
Rights Reserved
Background                                                                                                                            Slide 5




                                           Pharmaceutical   Biotechnology                   Diagnostics            Vaccine   Device




                                                                                                Vaccine Division




© Copyright Objective Insights, Inc. All                        www.ObjectiveInsights.com
Rights Reserved
Background                                                                                                Slide 6




                                                 Analgesia                       CNS / Psychiatric
                                           Autoimmune Disorders Inflammation & Allergy
                                               Cardiovascular                 Metabolic Disorders
                                               Dermatology                          Ophthalmology
                                                 Pulmonary                       Gastroenterology
                                              Musculoskeletal                                  Urology
                                             Infectious Diseases                               Vaccines
                                                Diagnostics                                Oncology


© Copyright Objective Insights, Inc. All                           www.ObjectiveInsights.com
Rights Reserved
Background                                                             Slide 7




© Copyright Objective Insights, Inc. All   www.ObjectiveInsights.com
Rights Reserved
Approach                                                               Slide 8




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Rights Reserved
Services                                                               Slide 9




© Copyright Objective Insights, Inc. All   www.ObjectiveInsights.com
Rights Reserved
Services                                                               Slide 10




© Copyright Objective Insights, Inc. All   www.ObjectiveInsights.com
Rights Reserved
Services                                                               Slide 11




© Copyright Objective Insights, Inc. All   www.ObjectiveInsights.com
Rights Reserved
Services                                                               Slide 12




© Copyright Objective Insights, Inc. All   www.ObjectiveInsights.com
Rights Reserved
Services                                                                                                                 Slide 13




                                                          Patients Progress Unless Cured

                                           Active   Disease                                   Disease   Remission

                                             Present with NHL
                                                                                               No Therapy      "Cured"


                                             First-Line Therapy


                                             Relapse Therapy


                                                                                              Death
                                             Refractory Therapy


                                             No Therapy




© Copyright Objective Insights, Inc. All                          www.ObjectiveInsights.com
Rights Reserved
Services                                                                Slide 14




© Copyright 2010 Objective Insights, Inc.        25 May 2010
All Rights Reserved                         www.ObjectiveInsights.com
Services                                                               Slide 15




© Copyright Objective Insights, Inc. All   www.ObjectiveInsights.com
Rights Reserved
Services                                                               Slide 16




© Copyright Objective Insights, Inc. All   www.ObjectiveInsights.com
Rights Reserved
Services                                                               Slide 17




© Copyright Objective Insights, Inc. All   www.ObjectiveInsights.com
Rights Reserved
Tools                                                                  Slide 18




© Copyright Objective Insights, Inc. All   www.ObjectiveInsights.com
Rights Reserved
Tools                                                                                                                            Slide 19




                                                                                                         Monthly, quarterly, &
                                                                                                          annual forecasts




                                           Forecasts for multiple indications, products, & geographies
                                                easily consolidated and analyzed as a portfolio


© Copyright Objective Insights, Inc. All                        www.ObjectiveInsights.com
Rights Reserved
Tools                                                                  Slide 20




© Copyright Objective Insights, Inc. All   www.ObjectiveInsights.com
Rights Reserved
Tools                                                                  Slide 21




© Copyright Objective Insights, Inc. All   www.ObjectiveInsights.com
Rights Reserved
Tools                                                                  Slide 22




© Copyright Objective Insights, Inc. All   www.ObjectiveInsights.com
Rights Reserved
Tools                                                                  Slide 23




© Copyright Objective Insights, Inc. All   www.ObjectiveInsights.com
Rights Reserved
Tools                                                                  Slide 24




© Copyright Objective Insights, Inc. All   www.ObjectiveInsights.com
Rights Reserved
Tools                                                                  Slide 25




© Copyright Objective Insights, Inc. All   www.ObjectiveInsights.com
Rights Reserved
Tools                                                                  Slide 26




© Copyright Objective Insights, Inc. All   www.ObjectiveInsights.com
Rights Reserved
Tools                                                                  Slide 27




© Copyright Objective Insights, Inc. All   www.ObjectiveInsights.com
Rights Reserved
Tools                                                                  Slide 28




© Copyright Objective Insights, Inc. All   www.ObjectiveInsights.com
Rights Reserved
Tools                                                                                                                                                 Slide 29




                                                                                     Annual forecasts                        Monte Carlo simulation




                                                                                           Company vs. Partner NPV
                                                                         $3,000



                                                                                                                                      $2,517
                                                                         $2,500
                                                                                                                         $2,308
                                           Deal Net Present Value ($M)




                                                                         $2,000




                                                                         $1,500
                                                                                              $1,362


                                                                                  $1,058
                                                                         $1,000




                                                                          $500




                                                                            $0
                                                                                     DEMO NPV ($M)                         Partner NPV ($M)

                                                                                                       Deal A   Deal B




© Copyright Objective Insights, Inc. All                                                     www.ObjectiveInsights.com
Rights Reserved
Tools                                                                                                                                                              Slide 30




                                                                Deal A Inputs                                                    Deal B Inputs
                                                                 by Region                   Common Inputs                        by Region




                                                               Deal A Results                                                    Deal B Results




                                           US Product X P&L   EU Product X P&L   ROW Product X               US Product X P&L   EU Product X P&L   ROW Product X
                                                  A                  A              P&L A                           B                  B              P&L B




                                                              Combined Results                                                  Combined Results




                                                   DEMO Share P&L       Partner Share                                  DEMO Share P&L      Partner Share
                                                         A                  P&L A                                            B                 P&L B




                                                                                        Comparison of Deal A & B
                                                                                                Results




© Copyright Objective Insights, Inc. All                                                   www.ObjectiveInsights.com
Rights Reserved
Tools                                                                  Slide 31




© Copyright Objective Insights, Inc. All   www.ObjectiveInsights.com
Rights Reserved
Tools                                                                  Slide 32




© Copyright Objective Insights, Inc. All   www.ObjectiveInsights.com
Rights Reserved
Strengths                                                                                            Slide 33




                                           “Simply an excellent choice for assistance” – OI client

© Copyright Objective Insights, Inc. All                     www.ObjectiveInsights.com
Rights Reserved
Strengths                                                                                                                 Slide 34




                                           “Great to work with, useful in our decisions.”
                                           “Very good at delivering what the client needs.”
                                           “OI has always impressed me with their modeling capabilities…the best in the
                                            industry in my opinion.”
                                               – Comments from OI client survey

© Copyright Objective Insights, Inc. All                             www.ObjectiveInsights.com
Rights Reserved

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Objective Insights (Brett Gaspers) Capabilities Presentation

  • 2. Slide 2 © Copyright Objective Insights, Inc. All www.ObjectiveInsights.com Rights Reserved
  • 3. Slide 3 © Copyright Objective Insights, Inc. All www.ObjectiveInsights.com Rights Reserved
  • 4. Background Slide 4 © Copyright Objective Insights, Inc. All www.ObjectiveInsights.com Rights Reserved
  • 5. Background Slide 5 Pharmaceutical Biotechnology Diagnostics Vaccine Device Vaccine Division © Copyright Objective Insights, Inc. All www.ObjectiveInsights.com Rights Reserved
  • 6. Background Slide 6 Analgesia CNS / Psychiatric Autoimmune Disorders Inflammation & Allergy Cardiovascular Metabolic Disorders Dermatology Ophthalmology Pulmonary Gastroenterology Musculoskeletal Urology Infectious Diseases Vaccines Diagnostics Oncology © Copyright Objective Insights, Inc. All www.ObjectiveInsights.com Rights Reserved
  • 7. Background Slide 7 © Copyright Objective Insights, Inc. All www.ObjectiveInsights.com Rights Reserved
  • 8. Approach Slide 8 © Copyright Objective Insights, Inc. All www.ObjectiveInsights.com Rights Reserved
  • 9. Services Slide 9 © Copyright Objective Insights, Inc. All www.ObjectiveInsights.com Rights Reserved
  • 10. Services Slide 10 © Copyright Objective Insights, Inc. All www.ObjectiveInsights.com Rights Reserved
  • 11. Services Slide 11 © Copyright Objective Insights, Inc. All www.ObjectiveInsights.com Rights Reserved
  • 12. Services Slide 12 © Copyright Objective Insights, Inc. All www.ObjectiveInsights.com Rights Reserved
  • 13. Services Slide 13 Patients Progress Unless Cured Active Disease Disease Remission Present with NHL No Therapy "Cured" First-Line Therapy Relapse Therapy Death Refractory Therapy No Therapy © Copyright Objective Insights, Inc. All www.ObjectiveInsights.com Rights Reserved
  • 14. Services Slide 14 © Copyright 2010 Objective Insights, Inc. 25 May 2010 All Rights Reserved www.ObjectiveInsights.com
  • 15. Services Slide 15 © Copyright Objective Insights, Inc. All www.ObjectiveInsights.com Rights Reserved
  • 16. Services Slide 16 © Copyright Objective Insights, Inc. All www.ObjectiveInsights.com Rights Reserved
  • 17. Services Slide 17 © Copyright Objective Insights, Inc. All www.ObjectiveInsights.com Rights Reserved
  • 18. Tools Slide 18 © Copyright Objective Insights, Inc. All www.ObjectiveInsights.com Rights Reserved
  • 19. Tools Slide 19 Monthly, quarterly, & annual forecasts Forecasts for multiple indications, products, & geographies easily consolidated and analyzed as a portfolio © Copyright Objective Insights, Inc. All www.ObjectiveInsights.com Rights Reserved
  • 20. Tools Slide 20 © Copyright Objective Insights, Inc. All www.ObjectiveInsights.com Rights Reserved
  • 21. Tools Slide 21 © Copyright Objective Insights, Inc. All www.ObjectiveInsights.com Rights Reserved
  • 22. Tools Slide 22 © Copyright Objective Insights, Inc. All www.ObjectiveInsights.com Rights Reserved
  • 23. Tools Slide 23 © Copyright Objective Insights, Inc. All www.ObjectiveInsights.com Rights Reserved
  • 24. Tools Slide 24 © Copyright Objective Insights, Inc. All www.ObjectiveInsights.com Rights Reserved
  • 25. Tools Slide 25 © Copyright Objective Insights, Inc. All www.ObjectiveInsights.com Rights Reserved
  • 26. Tools Slide 26 © Copyright Objective Insights, Inc. All www.ObjectiveInsights.com Rights Reserved
  • 27. Tools Slide 27 © Copyright Objective Insights, Inc. All www.ObjectiveInsights.com Rights Reserved
  • 28. Tools Slide 28 © Copyright Objective Insights, Inc. All www.ObjectiveInsights.com Rights Reserved
  • 29. Tools Slide 29 Annual forecasts Monte Carlo simulation Company vs. Partner NPV $3,000 $2,517 $2,500 $2,308 Deal Net Present Value ($M) $2,000 $1,500 $1,362 $1,058 $1,000 $500 $0 DEMO NPV ($M) Partner NPV ($M) Deal A Deal B © Copyright Objective Insights, Inc. All www.ObjectiveInsights.com Rights Reserved
  • 30. Tools Slide 30 Deal A Inputs Deal B Inputs by Region Common Inputs by Region Deal A Results Deal B Results US Product X P&L EU Product X P&L ROW Product X US Product X P&L EU Product X P&L ROW Product X A A P&L A B B P&L B Combined Results Combined Results DEMO Share P&L Partner Share DEMO Share P&L Partner Share A P&L A B P&L B Comparison of Deal A & B Results © Copyright Objective Insights, Inc. All www.ObjectiveInsights.com Rights Reserved
  • 31. Tools Slide 31 © Copyright Objective Insights, Inc. All www.ObjectiveInsights.com Rights Reserved
  • 32. Tools Slide 32 © Copyright Objective Insights, Inc. All www.ObjectiveInsights.com Rights Reserved
  • 33. Strengths Slide 33 “Simply an excellent choice for assistance” – OI client © Copyright Objective Insights, Inc. All www.ObjectiveInsights.com Rights Reserved
  • 34. Strengths Slide 34 “Great to work with, useful in our decisions.” “Very good at delivering what the client needs.” “OI has always impressed me with their modeling capabilities…the best in the industry in my opinion.” – Comments from OI client survey © Copyright Objective Insights, Inc. All www.ObjectiveInsights.com Rights Reserved