a powerpoint on hemophilia i needed to make. **if you want to join an online class if you are interested in history, science, math, english, and other things, join my class!!**

1. By: Brian

9. Hemophilia A:
Also known as classic hemophilia or Factor VIII
Deficiency
People with this type of hemophilia have low levels
of a blood clotting factor called figure 8 (FVIII)
Hemophilia B:
Also known as Christmas disease or Factor IX
Deficiency
People with this type of hemophilia have low levels
of a blood clotting factor called figure 9 (FIX)
-The two different types of hemophilia are caused by
permanent gene changes (mutations). Mutations in
the FVIII gene cause Hemophilia A. Mutations in the
FIX gene cause Hemophilia B.

10. Hemophilia A:
Also known as classic hemophilia
People with this type of hemophilia have low
levels of a blood clotting factor called figure 8
(FVIII)
-Severe Hemophilia A: Spontaneous joint or
deep muscle bleeding. Usually diagnosed within
first two years of life.
-Moderate Hemophilia A: spontaneous bleeding,
delayed oozing after minor injury, and usually
diagnosed before they are 5 to 6 years old.
- Mild Hemophilia A: Do NOT have spontaneous
bleeding but unusual bleeding occurs with
surgery and tooth extractions. People are usually
diagnosed with this in later life.

12. Hemophilia B:
Also known as Christmas disease
People with this type of hemophilia have low levels of
a blood clotting factor called figure 9 (FIX)
-Severe Hemophilia B: Spontaneous joint or deep muscle
bleeding is the most frequent symptom. People are
usually diagnosed in the first 2 years of life.
-Moderate Hemophilia B: spontaneous bleeding, delayed
oozing after minor injury, and usually diagnosed before
they are 5 to 6 years old
- Mild Hemophilia B: Do NOT have spontaneous bleeding
but unusual bleeding occurs with surgery and tooth
extractions. People are usually diagnosed with this in
later life.

13. The two different types of hemophilia are
caused by permanent gene changes
(mutations). Mutations in the FVIII gene
cause Hemophilia A. Mutations in the FIX
gene cause Hemophilia B.

14. Hemophilia A is more common than Hemophilia B.
One in 5000-10000 males around the world have
Hemophilia A. One in 20,000- 34,500 males around
the world have Hemophilia B.

15. Perpetuated oozing after injuries
repeated bleeding after first bleeding
Easy or spontaneous bruising
Perpetuated bleeding
- The most frequent symptom for Hemophilia’s types
A&B is spontaneous joint bleeding.

16. Hemophilia A&B are diagnosed by measuring factor clotting
activity. Individuals who have Hemophilia A have low factor VIII
clotting activity. Individuals who have hemophilia B have low
factor IX clotting activity. Genetic testing is also available for the
factor VIII gene and the factor IX gene. Genetic testing of the FVIII
gene finds a disease-causing mutation in up to 98 percent of
individuals who have hemophilia A. Genetic testing of the FIX
gene finds disease-causing mutations in more than 99 percent of
individuals who have hemophilia B. Genetic testing is usually
used to identify women who are carriers of a type FVIII or FIX
gene mutation, and to diagnose hemophilia in a fetus during a
pregnancy. It is sometimes used to diagnose individuals who have
mild symptoms of hemophilia A or B.

17. Is Hemophilia inherited?
Hemophilia A and hemophilia B are inherited in an X-linked recessive
pattern. The genes associated with these conditions are located on the X
chromosome, which is one of the two sex chromosomes. In males (who
have only one X chromosome), one changed copy of the gene in each cell
is sufficient to cause the condition. In females (who have two X
chromosomes), a mutation would have to occur in both copies of the gene
to cause the disorder. Because it is unlikely that females will have two
changed copies of this gene, it is very rare for females to have hemophilia.
A characteristic of X-linked inheritance is that fathers cannot pass X-linked
traits to their sons. In X-linked recessive inheritance, a female with
one changed copy of the gene in each cell is called a carrier. Carrier
females have about half the usual amount of clotting factor VIII or clotting
factor IX, which is generally enough for normal blood clotting. However,
about 10 percent of carrier females have less than half the normal amount
of one of these clotting factors; these individuals are at risk for unusual
bleeding, particularly after an injury, surgery, or tooth extraction.

18. Is there a cure for Hemophilia?
Right now, there is no cure for Hemophilia but, there are some
treatments being used depending on the` severity of hemophilia

29. • Pediatric Von Willibrands Disease