1. Silicone Based Drug Delivery Systems Dr. Basavaraj K. Nanjwade M.Pharm., Ph.D Associate Professor Department of Pharmaceutics KLE University BELGAUM -590010, Karnataka, INDIA E-mail: [email_address] Cell No: 00919448716277

2. Silicone in Drug Delivery Application Nano Technology DDS Buccal DDS Rectal DDS Vaginal DDS Pulmonary DDS Nasal DDS Topical DDS Parentral DDS Oral DDS Silicone

4. Silicone systems Adhesives Elastomers Resins Gels Emulsifiers

9. Silicone Elastomers Silicone Elastomers High consistency Elastomers (rubber) Liquid silicone Rubber or LSR’s Low consistency elastomers Adhesive

22. Transporter/Receptor-Targeted Drug Delivery

23. Aesthetic Benefits of Silicone Excipients Sensory evaluation (paired comparison) of (a) an ointment containing petrolatum (70%), ST- Cyclomethicone 5-NF (15%) and ST-Elastomer 10 (15%) versus (b) petrolatum (100%)

24. Aesthetic Benefits of Silicone Excipients Sensory evaluation (paired comparison) of (a) the hydrogel with Dimethiconol Blend 20 (5%) and ST-Elastomer 10 (10%) versus (b) the same hydrogel with no silicone

25. Aesthetic Benefits of Silicone Excipients Sensory evaluation (paired comparison) of (a) water-in-oil based on mineral oil (2%), petrolatum (5%) and Silky Wax 10 (5%) versus (b) water-in-oil emulsion based on mineral oil (10%), ST-Cyclomethicone 5-NF (10%) and Dimethiconol Blend 20 (5%). The same silicone surfactant (2% of Emulsifier 10) has been used in both formulations

26. Pharmacokinetic Benefits of Silicone Excipients Substantivity of silicone gum on skin over the time. Formulation silicone gum (3%) and hexamethyldisiloxane (97%). Test done on the forearm of 5 panelists. The silicone remaining on the skin of the panelists is analyzed by ATR-FTIR spectroscopy

27. Pharmacokinetic Benefits of Silicone Excipients Substantivity of Ketoprofen on skin over time. Formulation (a) Ketoprofen (2.5%), Hexamethyldisiloxane (94.5%) and silicone gum (3%). Formulation (b) Ketoprofen (2.5%) and Hexamethyldisiloxane (97.5%). Test done on the forearm of 5 panelist. Semi-quantitative analysis of Ketoprofen remaining on the skin of the panelists done by ATR-FTIR spectroscopy

28. Pharmacokinetic Benefits of Silicone Excipients Comparison of the penetration rate of ibuprofen(5%) through hairless rat skin in static diffusion cells silicone-based formulations (silicone gum in hexamethyldisiloxane) versus a silicone free hydrogel

29. Pharmacokinetic Benefits of Silicone Excipients Comparison of the penetration rate of econazole nitrate (1%) through hairless rat skin static diffusion cells silicone-based formulations (silicone gum in hexamethyldisiloxane) versus a silicone-free emulsion

30. Pharmacokinetic Benefits of Silicone Excipients Comparison of penetration rate of hydrocortisone (5%) through hairless rat skin in static diffusion cells of silicone-based formulations (silicone gum in hexamethyldisiloxane) versus a silicone-free emulsion

35. Enhanced permeability and retention effect (EPR effect )

36. Transferrin – mediated targeting

37. Drug Eluting applications Antidepressants Anxiolytics Vitamins, B6, D & E Antifungal Opioid analgesic Antiviral compounds

42. THANKS