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Björn Brembs Freie Universität Berlin
08.06.09 Björn Brembs, Freie Universität Berlin ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
08.06.09 Björn Brembs, Freie Universität Berlin ,[object Object],[object Object],[object Object],[object Object],Disorder Operant aspect Autism spectrum, depression, OCD, ADHD, Tourette, Parkinson  Spontaneous behavioral variability, action initiation  Depression („learned helplessness“), Anorexia nervosa Control over environment  Self-harming patients, dissociative disorders Sense of self/agency
Basic research: how do different brains solve the problem of adaptive behavioral choice? 08.06.09 Björn Brembs, Freie Universität Berlin
Basic research: how do different brains solve the problem of adaptive behavioral choice? 08.06.09 Björn Brembs, Freie Universität Berlin Classical/Pavlovian conditioning (fact-learning): Evolutionary conservation Technical advantages
Basic research: how do different brains solve the problem of adaptive behavioral choice? 08.06.09 Björn Brembs, Freie Universität Berlin Classical/Pavlovian conditioning (fact-learning): Operant  learning (skill-learning): Evolutionary conservation Technical advantages ? ? ?
[object Object],[object Object],[object Object],08.06.09 Björn Brembs, Freie Universität Berlin
08.06.09 Björn Brembs, Freie Universität Berlin
08.06.09 Björn Brembs, Freie Universität Berlin
08.06.09 Björn Brembs, Freie Universität Berlin
[object Object],08.06.09 Björn Brembs, Freie Universität Berlin
08.06.09 Björn Brembs, Freie Universität Berlin Maye et al. (2007) PLoS One Nonlinear (choice) Linear/stochastic (noise) Mushroom bodies Ellipsoid body Fan-shaped body nonlinearity correlation
[object Object],08.06.09 Björn Brembs, Freie Universität Berlin
[object Object],08.06.09 Björn Brembs, Freie Universität Berlin
08.06.09 Björn Brembs, Freie Universität Berlin operant classical
08.06.09 Björn Brembs, Freie Universität Berlin Brembs & Plendl (2008) Current Biology rut -AC dependent Synaptic Plasticity Protein Kinase C Required Required Not required Not required classical operant
[object Object],08.06.09 Björn Brembs, Freie Universität Berlin
[object Object],08.06.09 Björn Brembs, Freie Universität Berlin
[object Object],08.06.09 Björn Brembs, Freie Universität Berlin F. Lorenzetti, D. Baxter, J. Byrne (2008): Neuron 59, 815-828
08.06.09 Björn Brembs, Freie Universität Berlin Collaboration with Dr. Zars (Missouri): P-Element in the last Exon of FoxP FoxP Required Not required PKC Required Not required
08.06.09 Björn Brembs, Freie Universität Berlin Synaptic plasticity: Operant  learning ( Aplysia : neuronal plasticity?): ? ? ?
08.06.09 Björn Brembs, Freie Universität Berlin Brembs, Curr. Biol. In revis. ,[object Object],[object Object],[object Object],[object Object]
08.06.09 Björn Brembs, Freie Universität Berlin Brembs, Curr. Biol. In revis. ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

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The neurobiology of spontaneous actions and operant learning in Drosophila

  • 1. Björn Brembs Freie Universität Berlin
  • 2.
  • 3.
  • 4. Basic research: how do different brains solve the problem of adaptive behavioral choice? 08.06.09 Björn Brembs, Freie Universität Berlin
  • 5. Basic research: how do different brains solve the problem of adaptive behavioral choice? 08.06.09 Björn Brembs, Freie Universität Berlin Classical/Pavlovian conditioning (fact-learning): Evolutionary conservation Technical advantages
  • 6. Basic research: how do different brains solve the problem of adaptive behavioral choice? 08.06.09 Björn Brembs, Freie Universität Berlin Classical/Pavlovian conditioning (fact-learning): Operant learning (skill-learning): Evolutionary conservation Technical advantages ? ? ?
  • 7.
  • 8. 08.06.09 Björn Brembs, Freie Universität Berlin
  • 9. 08.06.09 Björn Brembs, Freie Universität Berlin
  • 10. 08.06.09 Björn Brembs, Freie Universität Berlin
  • 11.
  • 12. 08.06.09 Björn Brembs, Freie Universität Berlin Maye et al. (2007) PLoS One Nonlinear (choice) Linear/stochastic (noise) Mushroom bodies Ellipsoid body Fan-shaped body nonlinearity correlation
  • 13.
  • 14.
  • 15. 08.06.09 Björn Brembs, Freie Universität Berlin operant classical
  • 16. 08.06.09 Björn Brembs, Freie Universität Berlin Brembs & Plendl (2008) Current Biology rut -AC dependent Synaptic Plasticity Protein Kinase C Required Required Not required Not required classical operant
  • 17.
  • 18.
  • 19.
  • 20. 08.06.09 Björn Brembs, Freie Universität Berlin Collaboration with Dr. Zars (Missouri): P-Element in the last Exon of FoxP FoxP Required Not required PKC Required Not required
  • 21. 08.06.09 Björn Brembs, Freie Universität Berlin Synaptic plasticity: Operant learning ( Aplysia : neuronal plasticity?): ? ? ?
  • 22.
  • 23.