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A cross-sectional study of patients of the Robert Schad
                                    Naturopathic Clinic using the Naturopathic Patient Database
                                                                   Christopher Habib ND (1); Stefan Podgrabinski (2), Matthew Gowan ND (1,2), Brenda Leung ND, PhD (3), Dugald Seely ND, MSc (1,4), Kieran Cooley ND, MSc (1)
                                                                                         1. Canadian College of Naturopathic Medicine 2. OM Corporation 3. Boucher Institute of Naturopathic Medicine 4. Ottawa Integrative Cancer Centre
                                                                                                                                                                                                                Integrative




  Background                                                                                 Results                                                                                                                     Table 1. Conditions Seen at RSNC 2009-2010.
                                                                                                                                                                                                                                                                 ICD-10    % of All % of Patients
The Naturopathic Patient Database (NPD) is a data management tool developed               Females (76%) and people in the 20-30 (31.8%) and 31-40 (18.4%) year old age                                                                 Conditions
                                                                                                                                                                                                                                                               Code Range Diagnoses Diagnosed
by the Canadian College of Naturopathic Medicine (CCNM) to collect patient                groups have the highest representation in the NPD. The pediatric population is                                                  Pregnancy-related                       O00-O99            0.2              0.6
data from its teaching clinic, the Robert Schad Naturopathic Clinic (RSNC). This          disproportionately underrepresented. Psychosocial problems, musculoskeletal
                                                                                                                                                                                                                          Accidents, poisoning, violence          S00-T98            3.0              8.2
database was created in 2006 and has evolved to meet the various academic                 disorders, symptom-based conditions (e.g. fatigue and abnormal laboratory results),
                                                                                          endocrine disorders, and gastrointestinal disorders were the most prevalent ICD                                                 Cardiovascular disease                   I00-I99           4.0             11.8
and research needs of CCNM. This study describes demographics of patients
and conditions treated by student interns at the RSNC from 2009-2010.                     groups seen during this period.                                                                                                 Health maintenance                      Z00-Z99            4.1             12.1
                                                                                                                                                                                                                          Infectious disease                      A00-B99            4.2              9.5
Funding support for the development and use of the NPD was provided by a
                                                                                          Figure 2. Conditions Seen at RSNC 2009-2010.                                                                                    Respiratory disorders                    J00-J99           4.4             12.2
grant from the Lotte and John Hecht Foundation.
                                                                                                                                                                                                                          Cancer, neoplasms, hematologic          C00-D89            4.8             13.4
                                                                                                                                                        Pregnancy-related
  Methodology                                                                                                                                           Accidents, poisoning, violence
                                                                                                                                                                                                                          Nervous system, sensory organs          G00-G99            5.4             14.4
                                                                                                                                                                                                                          Skin disorders                          L00-L99            7.1             20.9
Fourth year naturopathic interns input data into the NPD as part of an academic                                                                         Cardiovascualr disease                                            Genitourinary disorders                 N00-N99            7.8             21.1
requirement. Patients can only be entered into the NPD after a minimum of 3
                                                                                                                                                        Health maintenance                                                Gastrointestinal disorders              K00-K93            9.1             23.3
visits. The majority of patients and patient visits are included in the NPD, but not
                                                                                                                                                                                                                          Endocrine disorders                     E00-E90           10.6             26.8
all. Thus, the NPD provides a snapshot of the data captured by interns on                                                                               Infectious disease
patients and health care services provided at the RSNC.                                                                                                                                                                   Other medical                           R00-R99           10.9             28.3
                                                                                                                                                        Respiratory disorders
                                                                                                                                                                                                                          Musculoskeletal disorders               M00-M99           11.7             26.9
All data from patient files must be entered, beginning with age and gender. The                                                                         Cancer, neoplasms, hematologic                                    Psychosocial problems                   F00-F99           12.6             30.0
NPD is divided into sections similar to a chart: Subjective, Objective,                                                                                 Nervous system/sensory organs
Assessment, and Plan. The NPD also contains a section for outcomes, which                                                                                                                                                 Figures 3. RSNC Ages.                              Figures 4. RSNC Genders.
                                                                                                                                                        Skin disorders
includes data from the Measure Yourself Medical Outcome Profile (MYMOP). The
                                                                                                                                                        Genitourinary disorders                                                                              0 to 10
MYMOP is used as a universal outcome measure of effectiveness of
individualized patient-defined symptoms.                                                                                                                                                                                                                     11 to 19
                                                                                                                                                        Gastrointestinal disorders                                                                                                                 M
                                                                                                                                                                                                                                                             20 to 30
Figure 1. Screenshot of NPD.                                                                                                                            Endocrine disorders
                                                                                                                                                                                                                                                             31 to 40
                                                                                                                                                        Other medical
                                                                                                                                                        Musculoskeletal disorders
                                                                                                                                                                                                                                                             41 to 50                      F
                                                                                                                                                                                                                                                             51 to 60
                                                                                                                                                        Psychosocial problems
                                                                                                                                                                                                                                                             61 to 100


                                                                                             Discussion
                                                                                           The majority of patients seen at the RSNC are female, likely because females tend                                             This is one of the first Canadian studies using an effective
                                                                                           to seek complementary and alternative medicine more than males. The pediatric                                                 database tool to obtain a clinical profile of patients seen by
                                                                                           population is possibly underrepresented in the NPD because those cases may be                                                 naturopathic doctors. Future work is needed to evaluate the
                                                                                           more complicated and interns may choose not to select those cases for their                                                   delivery of care and utility of the NPD as an effective teaching aid
                                                                                           academic requirements or because those patients only come to the clinic for acute                                             and research tool.
                                                                                           care.
                                                                                                                                                                                                                         Selected References                 Acknowledgements
                                                                                           Although a wide spectrum of diseases are treated at the RSNC, chronic diseases                                                1) International Classification     This project could not have taken place without
The NPD was used to explore RSNC patient cases from 2009-2010. The                         (diabetes, mental health conditions), diseases with low perceived risk to benefit                                             of Diseases, 10th revision.         important contribution from RSNC interns and clinic
                                                                                                                                                                                                                                                             supervisors from 2006-2010.
assessment section of the NPD contains a column for diagnosis that uses the                profiles with conventional treatment (chronic pain), and diseases that have a large,                                          2) Gowan et al. The Naturopathic
International Classification of Diseases, 10th revision (ICD-10) coding system.            modifiable lifestyle component to them (cardiovascular disease), are seen with high                                           Patient Database: a Clinical Tool
                                                                                           frequency. More research is needed to understand patient choices to receive care                                              for Research and Education.
ICD-10 codes were extracted and reviewed by an expert (CH) for accuracy
before being tabulated.                                                                    from this institution and to evaluate the effectiveness of care for these disorders.
Treating Type 2 Diabetes: A cross-sectional audit of
                                        Naturopathic care within a naturopathic college teaching
                                             clinic using the Naturopathic Patient Database
                                                         Christopher Habib ND (1); Stefan Podgrabinski (2), Matthew Gowan ND (1,2), Brenda Leung ND, PhD (3), Dugald Seely ND, MSc (1,4), Kieran Cooley ND, MSc (1)
                                                                                   1. Canadian College of Naturopathic Medicine 2. OM Corporation 3. Boucher Institute of Naturopathic Medicine 4. Ottawa Integrative Cancer Centre
                                                                                                                                                                                                          Integrative




  Background                                                                                              Results
Type 2 Diabetes Mellitus (T2DM) is a multi-factorial disease characterized by a                        The mean patient age was 60 and the female gender was more common (62%). Care                                             Figure 3. Percentage Use of Therapies.
decreased response to insulin. The Naturopathic Patient Database (NPD) is a data                       being provided was predominantly adjunctive care rather than primary care. The
management tool developed by the Canadian College of Naturopathic Medicine (CCNM)                      mean core audit score was 55.5 out of possible total of 90. There was no cut-off                                                                          100.0
to collect patient data from its teaching clinic, the Robert Schad Naturopathic Clinic                 score used to determine what was considered adequate care.
(RSNC). This study investigates how T2DM is managed at the RSNC from May 2009 to                                                                                                                                                                                     75.0




                                                                                                                                                                                                                                          Percentage
February 2011 for the purposes of auditing clinical supervisors and ultimately                          Figure 2. Audit Scores for Major Categories.
improving patient care.                                                                                                                                                                                                                                              50.0
                                                                                                            2.5
Funding support for the use of the NPD was provided by a grant from the Lotte and
                                                                                                                                                                                                                                                                     25.0
John Hecht Foundation and the Diabetes Alternative Research and Healthcare                                    2
Foundation.                                                                                                                                                                                                                                                           0.0
                                                                                                            1.5

  Methodology




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A core audit form was created using the American Diabetes Association 2010




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standards of medical care. Multiple categories in diagnosis, physical exam, lab tests,
                                                                                                              0
and management were graded on a 0-2 scale. Criteria being assessed included:

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                                                                                                                                                                                                           T
inquiring about current medications, obtaining a detailed history of complications,




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                                                                                                                                                                                                                                 Figure 4. Relationship of Audit Score vs. NPD Visits Missing.




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measuring blood pressure, palpating thyroid, doing a foot exam, obtaining lab results
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for HbA1c and lipid profiles, providing referrals to medical doctors, setting appropriate




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treatment goals, and utilizing evidence-based prescriptions.                                                                                                                                                                                                    80




                                                                                                                                                                                                                                      Audit Score (Out of 90)
                                                                                                                                                                                       Figure 3.
                                                                                                                                                                                                                                                                70
Additional audit criteria were created that did not apply to all cases, since some                                                                                                                                                                              60
guidelines only apply to specific patient populations, (eg. referring for bariatric surgery              The therapy most commonly used was nutritional supplementation (93%) followed
                                                                                                                                                                                                                                                                50
if Body Mass Index is over 35). Audit criteria that focused on naturopathic interventions                by botanical medicine (69%). Other naturopathic modalities were rarely used to treat
                                                                                                                                                                                                                                                                40
and RSNC operations were also assessed. These included the recommendations for                           T2DM or its complications. Of the supplements, omega-3 fatty acids (mean dose:
                                                                                                                                                                                                                                                                30
various supplements, botanicals, physical medicine, homeopathy, Traditional Chinese                      1818 mg daily) was the most common, followed by chromium (mean dose: 681
                                                                                                                                                                                                                                                                20
Medicine, therapeutic counseling and use of the Measure Yourself Medical Outcome                         mcg daily).
                                                                                                                                                                                                                                                                10
Profile (MYMOP) as a universal outcome measure of effectiveness of individualized                        Interns enter information into the NPD after a minimum of 3 patient visits. An                                                                          0
patient-defined symptoms.                                                                                analysis was done to see how audit scores compared to the number of visits that                                                                             0         2         4        6           8         10          12            14
                                                                                                         were omitted in the NPD. There were no differences among the audit scores,
One auditor (CH) conducted a search of the NPD from May 2009 to February 2011 to                                                                                                                                                                                                                NPD Visits Missing
                                                                                                         indicating that the quality of care was largely determined within the first 3 visits.
identify patients assessed with T2DM. The assessment section of the NPD contains a
column for diagnosis that uses the International Classification of Diseases, 10th revision
(ICD-10) coding system. The inclusion criteria were all patients assessed with T2DM, so                    Discussion
that the audit could also capture a realistic representation of naturopathic care for
                                                                                                        The audit scores evaluating the patient intake were high. This is likely because                                         Feedback is key in improving audit scores and patient care. Audit findings
those with comorbidities, as is often the case in patients with T2DM. The code for
                                                                                                        interns spend one hour per visit with patients and so have large amounts of time to                                      were presented to clinical supervisors and to current clinic interns. They were
T2DM (E11) was employed and captured 29 patient cases.
                                                                                                        accumulate information. The audit scores for lab tests were also high and this is                                        also integrated into the curriculum. The poorest scoring categories were
                                                                                                        likely because naturopathic doctors in Ontario cannot directly requisition lab tests, so                                 emphasized. A checklist was created to help guide interns in their first 3 visits
 Figure 1. Process of Case Selection for Audit.                                                         credit was given in the audit if an intern requested lab work from the patient.                                          with a diabetic patient. Education and creation of a naturopathic standard of
                                                                                                                                                                                                                                 care may improve audit performance and patient outcomes for patients with
                                                                                                        The three lowest scoring categories in the audit were: a thorough physical exam,
           13,824             39 T2DM             37 T2DM            29 T2DM                                                                                                                                                     T2DM. Larger scale follow-up audits are planned to examine the impact of
                             Cases (May          Cases With
                                                                                                        referring patient care, and setting specific treatment goals. The physical exam
          Total NPD                                                 Cases With                                                                                                                                                   audit feedback and continue the process of practice improvement.
         Cases (2006         2009 to Feb          Complete          Patient File
                                                                                                        component scored poorly because there are guidelines for T2DM that fall outside of
           to 2011)            2011)             NPD Data           Identifiers                         the RSNC’s screening physical exam form. Referring patient care scored poorly, in                                         Selected References                                                      Acknowledgements
                                                                                                        part, because according to the American Diabetes Association, patients must be                                            1) American Diabetes Association Standards                               1) Robert Schad Naturopathic Clinic
                13,785 Excluded        2 Excluded          8 Excluded
                                                                                                        referred to many health care practitioners who’s capabilities often overlap with those                                    of Medical Care in Diabetes 2010.
                                                                                                                                                                                                                                                                                                           2) OM Corporation
                                                                                                        of NDs. Setting specific treatment goals likely scored poorly because there are no                                        2) Bradley R, Kozura E, Buckle H, et al.                                 3) Lotte and John Hecht Foundation
                                                                                                        current guidelines for naturopathic standards of care for diabetes. Collection and                                        Description of Clinical Risk Factor Changes
                                                                                                                                                                                                                                  During Naturopathic Care for Type 2 Diabetes.                            4) Diabetes Alternative Research and
                                                                                                        reporting of subjective outcomes (MYMOP) could be improved.                                                                                                                                        Healthcare Foundation
Evidence for the Topical Application of Castor Oil:
                                                                  A Systematic Review
                                                                   Deborah A. Kennedy ND1 and Dana Keaton ND LAC2
                                                         1Canadian          College of Naturopathic Medicine 2Center for Natural Medicine

                                                                       Results                                                                       Seventeen participants with “fatigue” were recruited to
 Background                                                                                                                                          participate in an investigation of longer use of COPs.
Castor oil, also known as Palma Christi, is derived from the         Search Strategy Flow Chart                         Constipation                 Participants applied the COPs for 1.5 hours per day over the
bean of the plant Ricinus communis, through cold mechanical            462 articles found
                                                                                                                        Researchers Arslen and       liver area for 5 days per week for 2 weeks. During the course of
pressing. Ricinus communis is native to India and                      during initial search                            Eser     evaluated    the    treatment, the mean total lymphocyte counts normalized within
                                                                       (July 2009)
approximately 90% of the oil is produced in Brazil and India.                                    400 articles rejected  effectiveness of COPs on     the group and were lower at the end of treatment vs baseline.
Castor oil is composed chiefly of ricinoleic acid, which                                         based on title review  constipation in 35 elderly   As an unexpected outcome, 2 participants with elevated liver
                                                                       62 abstracts screened
represents approximately 80 - 90% of the total fatty acid              for inclusion                                    nursing home residents.      enzymes and cholesterol levels normalized these variables by
content. Castor oil has been used since the 16th century BC                                                             Constipation symptoms        the end of the study.
in many forms. It can be taken internally, used topically and          10 articles retrieved for                        were tracked for 14 days
incorporated into cosmetics and drug delivery systems. It is           full analysis
                                                                                                                        using the Defecation         Pain Reduction
the evidence associated with the topical application of castor
                                                                                                  Search re-executed
                                                                                                  (May 2011) 2 articles Monitoring form and          Viera et al compared the anti-inflammatory and antinociceptive
oil that is the focus of this review.                                  9 articles included in
                                                                                                                        Visual Analog Scale, with    effects of topical castor oil and capsaicin. Their findings
                                                                       systematic review
                                                                                                                        COPs applied on Days 8,      suggest that castor oil is devoid of irritant properties, unlike
                                                                                                                        9                            capsaicin. Ricinoleic acid was found to deplete substance P.
 Methodology                                                                                                                                         Capsaicin is used to treat neuropathic pain and the authors
                                                                     and 10. Findings included improvements in evacuation, fecal
                                                                                                                                                     suggest that castor oil maybe as effective as capsaicin, without
PubMed, Embase, Alt-Med and CINAHL databases were                    consistency and a reduction in straining. There were no
                                                                                                                                                     its irritating properties.
searched using the terms castor oil/therapeutic use,                 changes to the frequency of bowel movements nor the
ricinoleic acid and Ricinus communis/therapeutic use, not            amount of feces evacuated.                                                        Discussion
ricin, from inception to July 2009 and updated May 2011. For         Artifical Tears                                                                 Both castor oil and its main constituent, ricinoleic acid, have
inclusion in the review, articles had to be related to the           A double-blind placebo-controlled crossover study by Goto et                    been found to be non-toxic for both internal and external use.
topical use of castor oil. Articles dealing with castor oil used     al evaluated low-dose castor oil eyedrops, or artificial tears in               Case reports in the literature document evidence of contact
in manufacturing, as a food additive, or as a cathartic were         20 patients with obstructive meibomian gland dysfunction.                       dermatitis from castor oil in cosmetic products.
excluded, as was the use of castor oil to aid in the delivery of     Treatment with castor oil demonstrated improvement in                           Historically, castor oil has been reputed to provide relief for
pharmaceutical drugs.                                                symptoms and objective findings. Maissa et al also found that                   dermatologic conditions, contusions, inflammatory and ocular
                                                                     eyedrops containing castor oil produced a more stable tear                      disorders. This review disclosed no cohesive evidence regarding
 Results                                                             film and a significant decrease in ocular dry eye symptoms.                     the mechanism of action of castor oil or its main constituent,
Nine studies investigated the topical use of castor oil                                                                                              ricinoleic acid.
                                                                     Immune and Liver function
through direct application of the oil or in the form of castor                                                                                       Preliminary evidence suggests that castor oil may modulate
                                                                     A double-blind controlled study of a single use of COPs vs
oil packs (COPs).                                                                                                                                    white blood cell count and may have a positive effect on liver
                                                                     paraffin oil packs in 36 healthy adults found an increase in
Transdermal Absorption                                                                                                                               function and cholesterol levels; further research is needed in this
                                                                     total lymphocytes which peaked at 7 hours with T11 cells
Mein et al conducted a small study to assess castor oil                                                                                              area. The topical application of castor oil has been shown to
                                                                     contributing to the overall increase. COPs were applied over
absorption through the skin vs oral intake. A 2-phase study                                                                                          reduce the pain of neurogenic inflammation, improve symptoms
                                                                     the liver and abdomen for 2 hours with heat. At the 24-hour
comparing abdominal COPs for 3 consecutive days versus                                                                                               of constipation and to lubricate the eyes as artificial tears.
                                                                     mark, total lymphocytes declined, although they remained
oral consumption found no significant difference in the
                                                                     within normal limits.
urinary metabolites of castor oil pre- and post-COP while                                                                                            Acknowledgements.
significant differences were found pre- and post-oral intake.                                                                                        Deborah Kennedy’s efforts on this project were supported by a
                                                                                                                                                     career development grant from the SickKids Foundation.
Xenoestrogens & Breast Cancer:
                                            Chemical Risk, Exposure and Social Determinants
                                                                                     Sarah Young, MA (1) & Dugald Seely, ND, MSc, FABNO (1,2,3)
                                                             1. Ottawa Integrative Cancer Centre 2. Department of Research & Clinical Epidemiology, Canadian College of Naturopathic Medicine, Toronto 3. Ottawa Hospital Research Institute
                                                                                                                                                                                     Medicine,




  Background                                                                           Xenoestrogens and Breast Cancer
Incidence of breast cancer has risen in Canada by more than 25%                                                                                                                                   Table 1: Common Xenoestrogens, sources and effects
over the past twenty-five years, is the leading cause of death in                                                              Xenoestrogens are chemicals that
women aged 20-44, and comprises over thirty percent of all cancer                                                              mimic the effects of estrogen due to
                                                                                                                                                                                                    XENOESTROGENS                             FOUND IN                                  EFFECTS
diagnoses in women. Nearly two-thirds of breast cancer cases result                                                            structural chemical similarities. As
from a combination of gene-environment interactions, lifestyle                                                                 opposed to endogenous hormones,                                        Bisphenol A (BPA)           bottles, tin cans, drink containers,           In vitro and animal studies:
                                                                                                                                                                                                                                water pipes, dental composites, optical            neoplastic development,
factors (including lack of physical exercise, alcohol intake, and                                                              xenoestrogens come from sources                                                                  lenses, adhesives, compact discs, paper        proliferation of epithelial cells,
                                                                                                                                                                                                                                                 coatings                     expression of estrogen receptors
obesity), and exposure to environmental pollutants. Exposure to                                                                external to the body. Like other                                                                                                              (ERs) and progesterone receptors
                                                                                                                                                                                                                                                                               (PRs), and a decreased vaginal
estrogen is the most important identifiable risk factor responsible                                                            endocrine disruptors, xenoestrogens                                                                                                                weight, transgenerational

for the development of breast cancer. While endogenous estrogen is                                                             can alter normal hormonal function,                                                                                                                      amplification.


clearly important, the contribution that xenoestrogens have on                                                                 producing adverse health effects for                                     Polychlorinated           electrical equipment, plasticizers in      Human studies: high levels found

breast cancer causation is just starting to be documented.                                                                     both adults and their children.                                         Biphenols (PCB’s)        paints, plastics, and rubber products,
                                                                                                                                                                                                                                  pigments, dyes, and paper. Though
                                                                                                                                                                                                                                                                               in breast milk of northern
                                                                                                                                                                                                                                                                                      communities
                                                                                                                                                                                                                                banned in 1979 PCBs are still released       PCBs are now regularly found in
                                                                                                                               Mammary tissue cells express specific                                                            into the environment from hazardous
                                                                                                                                                                                                                                waste sites. PCBs do not readily break
                                                                                                                                                                                                                                                                              mammals and ocean wildlife in
                                                                                                                                                                                                                                                                                      the far north

 Chemicals in Our Environment                                                                                                  receptors, known as alpha-receptors                                                               down and remain for long periods of
                                                                                                                                                                                                                                time recycling between the air, water,
                                                                                                                               that can be stimulated by estrogens to                                                                           and soil.

There are over 80,000 synthetic chemicals in and around us: they are                                                           induce the proliferation of end buds in                                  Certain Pesticides        used extensively in agriculture, in          In vitro and animal studies:
sprayed directly on our food in the form of pesticides; they get                                                               the breasts. Proliferation of these end                               (i.e. DDT, heptachlor,
                                                                                                                                                                                                      atrazine, chlordane,
                                                                                                                                                                                                                                homes, in workplaces, and throughout
                                                                                                                                                                                                                                  cities on private and public lawns
                                                                                                                                                                                                                                                                                 immunotoxic, mutagenic,
                                                                                                                                                                                                                                                                                carcinogenic, enhances the
pumped into the air by diesel exhaust and industrial emissions in the                                                          buds increases the risk of breast                                    aldrin, lindane, 2,4,5-TP
                                                                                                                                                                                                         and the captans)
                                                                                                                                                                                                                                                                              metabolism of other xenobiotic
                                                                                                                                                                                                                                                                                         chemicals
form of polycyclic aromatic hydrocarbons (PAHs); they are used as                                                              cancer by augmenting the chance of                                                                                                             Occupational studies: women
                                                                                                                                                                                                                                                                              working in agriculture 3 times
liners in tin cans, are built into plastic water bottles and are found in                                                      mutation during cell division.                                                                                                                more likely to have breast cancer

dental composites in the form of bisphenol A (BPA); are added to                  There are over 200 xenoestrogens used in industry, cosmetics,                                                            Cadmium                    from burning fossil fuels and             In vitro and animal studies:
personal care products in the form of parabens; leach into the soil               agriculture and food processing that act as mammary carcinogens
                                                                                                                                                                                                                                 municipal waste, the smelting of zinc
                                                                                                                                                                                                                                    and copper, and tobacco smoke.
                                                                                                                                                                                                                                                                              induction of single-strand DNA
                                                                                                                                                                                                                                                                             breaks, inhibition of DNA repair
and water from electronic waste in landfills in the form of cadmium,                                                                                                                                                             Cadmium is used in electroplating, in       by inactivation of the mismatch
                                                                                  and have been found in over 95% of human tissue. Twenty-nine of                                                                                   alloys, as a de-oxidizer in nickel          repair system, activation of
and are found in high amounts in the fish we eat as polycyclic                                                                                                                                                                       plating, in Cd-Ni batteries, as              oncogenes, inhibition of
                                                                                  these compounds are produced at over a million pounds per year                                                                                 pigments in glazes and enamel paints,            programmed cell death
biphenols (PCBs).                                                                                                                                                                                                                in plastics, and in fertilizers. Parts of               (apoptosis).
                                                                                  in the USA.                                                                                                                                      North America are known to have
                                                                                                                                                                                                                                   high levels of cadmium in the soil.
                                                                                                                                                                                                                                                                               Occupational studies: Women
                                                                                                                                                                                                                                                                               working in automotive were 4
Since the 1950’s more than 750 million tons of toxic chemical waste                                                                                                                                                                                                          times more likely to have breast
                                                                                                                                                                                                                                                                                           cancer.
have been discarded across 50,000 hazardous waste sites in the                      Relevant Social Determinants
United States alone. Among all North American jurisdictions, Ontario                                                                                                                                  Parabens, Pthalates         Personal care products, including            Breast cancer rates amongst
                                                                                  Exploring the impact of xenoestrogens from a social determinants                                                                                 shampoos, creams, conditioners,            African American women under
is the fourth highest emitter of cancer causing chemicals into the air,                                                                                                                                                         hairsprays, deodorants, cosmetics, and       age 30 are 50% higher than white
                                                                                  of health model, we found that early life, food security, social                                                                                            perfumes                       women and their use of estrogenic
emitting over four million kilograms of reproductive toxins each year.                                                                                                                                                                                                         personal care products is ten
                                                                                  exclusion, education, working conditions, income, housing, and                                                                                                                                        times higher

Xenoestrogens consist of a class of endocrine disrupting chemicals                availability of a social safety net had a significant impact on the                                                Polycyclic Aromatic         fossil fuel combustion, diesel exhaust,         In vivo, in vitro and human
(EDCs) that have causative links to cancer and particularly to breast             risk of exposure. These issues speak directly to breast cancer                                                    Hydrocarbons (PAH’s)          consumption of smoked and grilled
                                                                                                                                                                                                                                   foods, and from cigarette smoking
                                                                                                                                                                                                                                                                                studies: mutagenic, increased
                                                                                                                                                                                                                                                                               proliferation of cells, effects on
cancer. Common xenoestrogens include Bisphenol A, PCB’s,                          risk and chemical exposure and inequities in society as well as the                                                                                                                        estrogen receptors, enzymes of the
                                                                                                                                                                                                                                                                                 CYP 450 family and on the
Cadmium, Pesticides, PAHs, Parabens and Pthalates (see table on                   issue of vulnerability. The timing of exposure to increased levels of                                                                                                                           tumour suppressing gene


right for more detail and examples).                                              both natural and chemical xenoestrogens in a woman’s body,
                                                                                  embryo, fetus, and infant plays a key role in the development of                                               Acknowledgements. This review was funded by the National
                                                                                  cancer.                                                                                                        Network on the Environment and Women’s Health
An observational study of adjunctive cancer care at the
                                              Canadian College of Naturopathic Medicine
                                                                 Gillian Flower ND1, Natalie Bozinovski ND(c)1, Gabriella Chow ND1, Kieran Cooley ND1, Martha Grant ND1, Christopher Habib ND1,
                                                                               Daniel Lander ND, FABNO1, Tara O’Brien ND1, Jill Shainhouse ND, FABNO1, Dugald Seely ND, FABNO1,2.
                                                                                                                O’
                                                                                                              1. Canadian College of Naturopathic Medicine; 2. Ottawa Hospital Research Institute

                                                                      Table 1. Select patient characteristics by cancer type                                                         Diet, lifestyle and mind-body interventions were common, as
  Background                                                                                                                                                                         was individualized homeopathy, tinctures and teas.
                                                                                                                                       Mean age at               % reporting
The Adjunctive Cancer Care (ACC) shift provides                           Primary cancer          Female / Number of                                                                 Analysis of EORTC, MYCAW, MYMOP and KI showed that
                                                                                                                                    diagnosis – years            conventional
naturopathic care to patients with cancer at the Robert                        type                 male    patients                                                                 scores improved or were unchanged more frequently than
                                                                                                                                         (range)                care pre-RSNC
Schad Naturopathic Clinic (RSNC), the teaching clinic of the                      Breast             31 / 0             31                49 (30-76)                    80.6         they worsened (Figure 1). This was true across all scores and
Canadian College of Naturopathic Medicine (CCNM). This                           Digestive1          17 / 10            27                 55 (2-83)                    88.9         subscores in all measures used. The subset of eligible
cross-sectional,   observational     study    summarizes                         Prostate            0 / 20             20                61 (48-79)                    40.0
                                                                                                                                                                                     responses per tool was small (n= 11-30) although 39.1% of
demographic, outcome and treatment data for patients                                                                                                                                 all charts yielded eligible responses for at least 1tool.
                                                                                Hematologic           8/6               14                45 (23-63)                    78.6
seen on the ACC over a 13-month period.
                                                                         Female reproductive2        13 / 0             13                52 (26-71)                    100.0        The 5 most common patient-identified concerns, elicited
                                                                                Neurologic            4/5               9                  21 (0-67)                    88.9         through MYCAW use included: references to cancer, to pain
   Methodology                                                              Head and neck3            5/2               7                 53 (32-74)                    85.7         or discomfort, to energy or fatigue, to weight or
                                                                                  Other4              9/8               17                54 (33-83)                    47.1
                                                                                                                                                                                     nutrition or to gastrointestinal symptoms. 84.2% of
Point-of-sale software was used to identify patients that had                                                                                                                        evaluated patients named at least one of these 5 concerns.
been seen on the ACC from December 2009-December                         1 – Colorectal, hepatic, pancreatic, gastric; 2 – ovarian, uterine, vaginal; 3 – salivary, oral, thyroid,
                                                                        sinus; 4 – includes lung, skin, testicular, osseous, diverse types not included elsewhere
2010. The in-house Naturopathic Patient Database (NPD)
was consulted for patient information, but a lack of                      18% of patients reported a refusal of conventional treatment at some point,
                                                                                                                                                                                        Discussion
sufficient data led to a full patient chart review.                       many having tried chemotherapy or radiation previously. 9 deaths (6.5%)                                    A diverse range of patients and cancers (type and stage) are
Patients were included if they had a diagnosis of cancer and              were confirmed.                                                                                            seen by student interns on the ACC at the RSNC. Treatments
had >1 visit on the ACC. 35 data points were collected in                                                                                                                            include supplemental, lifestyle and dietary therapies and reflect
                                                                          51% of all patients received intravenous vitamin C therapy (IVC), with use                                 a blend of cancer-focused and individualized care.
addition to scores on 4 validated assessment tools: the                   ranging from 45%-71% across various cancer types. Far fewer patients
Karnofsky Index (KI), the Measure Yourself Medical                        with neurologic cancers received IVC (11%), but only 4 patients in this                                    Patient-defined symptoms commonly include concerns with pain
Outcomes Profile (MYMOP), the Measure Yourself Concerns                   group were eligible to receive this treatment in Ontario (>13 years old).                                  and energy. EORTC results show fewer patients worsening in
and Wellbeing scale (MYCAW) and the European                                                                                                                                         these subscores than the number that maintain their current
Organization for Research and Treatment of Cancer quality                 Oral supplementation was recommended in 98.5% of patients that had at                                      status or improve. Other patient- and intern-based assessments
of life questionnaire (EORTC). Intern prescriptions were also             least 1 consult-type visit. All supplemented patients were given at least one                              of symptoms and function include the MYCAW, MYMOP and KI.
counted.                                                                  of the following 5 prescriptions:        Vitamin D, curcumin, EGCG,                                        All suggest a trend towards patient stabilization or improvement
                                                                          melatonin and fish oil.                                                                                    in evaluated outcomes.
 Results                                                              Figure 1. Percent of patients improving, not changing and worsening according to
                                                                      EORTC(1-5), MYCAW (6-7) and Karnofsky (8) results (>27 days of evaluation).
                                                                                                                                                                                     Some limitations to this study include the small amount of
                                                                                                                                                                                     eligible data for each tool. Responses were included if the same
189 patient charts were reviewed and 138 met criteria for                                                                                                                            tool was used on more than 1 occasion and if the time elapsed
inclusion. 64% of patients seen were female. Breast cancer               100%                                                                                                        between administration was >27 days yielding as few as 11
was the most common diagnosis, seen in 22.5% of all                       80%                                                                                                        responses in one instance. The original goal of using the NPD as
cases. Mean age at diagnosis was lowest among neurologic                                                                                                            Worsened         a source of data could not be met, necessitating a chart review.
cancers where 5/9 patients were 3 years of age or                         60%                                                                                       Unchanged
younger.                                                                                                                                                                             Short- and long-term naturopathic care may successfully
                                                                          40%                                                                                       Improved         address some of the most important concerns of individuals
Table 1 summarizes select patient characteristics.                                                                                                                                   with cancer. Further research investigating patient experiences
                                                                          20%                                                                                                        and comparative effectiveness of naturopathic treatment of
Average duration of care was 298.4 days (range 2-2163),
                                                                            0%                                                                                                       cancer are warranted.
with an average of 7.4 (0-70) consult-type visits per patient.
51.5% of all patients had conventional treatment (surgery,
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                                                                                                                                                                                     Foundation.
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CAND Posters 2011

  • 1. A cross-sectional study of patients of the Robert Schad Naturopathic Clinic using the Naturopathic Patient Database Christopher Habib ND (1); Stefan Podgrabinski (2), Matthew Gowan ND (1,2), Brenda Leung ND, PhD (3), Dugald Seely ND, MSc (1,4), Kieran Cooley ND, MSc (1) 1. Canadian College of Naturopathic Medicine 2. OM Corporation 3. Boucher Institute of Naturopathic Medicine 4. Ottawa Integrative Cancer Centre Integrative Background Results Table 1. Conditions Seen at RSNC 2009-2010. ICD-10 % of All % of Patients The Naturopathic Patient Database (NPD) is a data management tool developed Females (76%) and people in the 20-30 (31.8%) and 31-40 (18.4%) year old age Conditions Code Range Diagnoses Diagnosed by the Canadian College of Naturopathic Medicine (CCNM) to collect patient groups have the highest representation in the NPD. The pediatric population is Pregnancy-related O00-O99 0.2 0.6 data from its teaching clinic, the Robert Schad Naturopathic Clinic (RSNC). This disproportionately underrepresented. Psychosocial problems, musculoskeletal Accidents, poisoning, violence S00-T98 3.0 8.2 database was created in 2006 and has evolved to meet the various academic disorders, symptom-based conditions (e.g. fatigue and abnormal laboratory results), endocrine disorders, and gastrointestinal disorders were the most prevalent ICD Cardiovascular disease I00-I99 4.0 11.8 and research needs of CCNM. This study describes demographics of patients and conditions treated by student interns at the RSNC from 2009-2010. groups seen during this period. Health maintenance Z00-Z99 4.1 12.1 Infectious disease A00-B99 4.2 9.5 Funding support for the development and use of the NPD was provided by a Figure 2. Conditions Seen at RSNC 2009-2010. Respiratory disorders J00-J99 4.4 12.2 grant from the Lotte and John Hecht Foundation. Cancer, neoplasms, hematologic C00-D89 4.8 13.4 Pregnancy-related Methodology Accidents, poisoning, violence Nervous system, sensory organs G00-G99 5.4 14.4 Skin disorders L00-L99 7.1 20.9 Fourth year naturopathic interns input data into the NPD as part of an academic Cardiovascualr disease Genitourinary disorders N00-N99 7.8 21.1 requirement. Patients can only be entered into the NPD after a minimum of 3 Health maintenance Gastrointestinal disorders K00-K93 9.1 23.3 visits. The majority of patients and patient visits are included in the NPD, but not Endocrine disorders E00-E90 10.6 26.8 all. Thus, the NPD provides a snapshot of the data captured by interns on Infectious disease patients and health care services provided at the RSNC. Other medical R00-R99 10.9 28.3 Respiratory disorders Musculoskeletal disorders M00-M99 11.7 26.9 All data from patient files must be entered, beginning with age and gender. The Cancer, neoplasms, hematologic Psychosocial problems F00-F99 12.6 30.0 NPD is divided into sections similar to a chart: Subjective, Objective, Nervous system/sensory organs Assessment, and Plan. The NPD also contains a section for outcomes, which Figures 3. RSNC Ages. Figures 4. RSNC Genders. Skin disorders includes data from the Measure Yourself Medical Outcome Profile (MYMOP). The Genitourinary disorders 0 to 10 MYMOP is used as a universal outcome measure of effectiveness of individualized patient-defined symptoms. 11 to 19 Gastrointestinal disorders M 20 to 30 Figure 1. Screenshot of NPD. Endocrine disorders 31 to 40 Other medical Musculoskeletal disorders 41 to 50 F 51 to 60 Psychosocial problems 61 to 100 Discussion The majority of patients seen at the RSNC are female, likely because females tend This is one of the first Canadian studies using an effective to seek complementary and alternative medicine more than males. The pediatric database tool to obtain a clinical profile of patients seen by population is possibly underrepresented in the NPD because those cases may be naturopathic doctors. Future work is needed to evaluate the more complicated and interns may choose not to select those cases for their delivery of care and utility of the NPD as an effective teaching aid academic requirements or because those patients only come to the clinic for acute and research tool. care. Selected References Acknowledgements Although a wide spectrum of diseases are treated at the RSNC, chronic diseases 1) International Classification This project could not have taken place without The NPD was used to explore RSNC patient cases from 2009-2010. The (diabetes, mental health conditions), diseases with low perceived risk to benefit of Diseases, 10th revision. important contribution from RSNC interns and clinic supervisors from 2006-2010. assessment section of the NPD contains a column for diagnosis that uses the profiles with conventional treatment (chronic pain), and diseases that have a large, 2) Gowan et al. The Naturopathic International Classification of Diseases, 10th revision (ICD-10) coding system. modifiable lifestyle component to them (cardiovascular disease), are seen with high Patient Database: a Clinical Tool frequency. More research is needed to understand patient choices to receive care for Research and Education. ICD-10 codes were extracted and reviewed by an expert (CH) for accuracy before being tabulated. from this institution and to evaluate the effectiveness of care for these disorders.
  • 2. Treating Type 2 Diabetes: A cross-sectional audit of Naturopathic care within a naturopathic college teaching clinic using the Naturopathic Patient Database Christopher Habib ND (1); Stefan Podgrabinski (2), Matthew Gowan ND (1,2), Brenda Leung ND, PhD (3), Dugald Seely ND, MSc (1,4), Kieran Cooley ND, MSc (1) 1. Canadian College of Naturopathic Medicine 2. OM Corporation 3. Boucher Institute of Naturopathic Medicine 4. Ottawa Integrative Cancer Centre Integrative Background Results Type 2 Diabetes Mellitus (T2DM) is a multi-factorial disease characterized by a The mean patient age was 60 and the female gender was more common (62%). Care Figure 3. Percentage Use of Therapies. decreased response to insulin. The Naturopathic Patient Database (NPD) is a data being provided was predominantly adjunctive care rather than primary care. The management tool developed by the Canadian College of Naturopathic Medicine (CCNM) mean core audit score was 55.5 out of possible total of 90. There was no cut-off 100.0 to collect patient data from its teaching clinic, the Robert Schad Naturopathic Clinic score used to determine what was considered adequate care. (RSNC). This study investigates how T2DM is managed at the RSNC from May 2009 to 75.0 Percentage February 2011 for the purposes of auditing clinical supervisors and ultimately Figure 2. Audit Scores for Major Categories. improving patient care. 50.0 2.5 Funding support for the use of the NPD was provided by a grant from the Lotte and 25.0 John Hecht Foundation and the Diabetes Alternative Research and Healthcare 2 Foundation. 0.0 1.5 Methodology Om g m e 10 M A on y ts Ch a-3 ium na a ls th in l lin m AL siu TC en ica m 1 Q- ic eg pa ne m se lem m ed ne Co an eo ro m un M ag Ph Bot Gy pp m Co Ci al M Ho A core audit form was created using the American Diabetes Association 2010 Su 0.5 ic ys standards of medical care. Multiple categories in diagnosis, physical exam, lab tests, 0 and management were graded on a 0-2 scale. Criteria being assessed included: KE T inquiring about current medications, obtaining a detailed history of complications, G S AL BS Figure 4. Relationship of Audit Score vs. NPD Visits Missing. EN IN L TA C RA LA TT EM SI measuring blood pressure, palpating thyroid, doing a foot exam, obtaining lab results IN FE SE Y AG PH RE for HbA1c and lipid profiles, providing referrals to medical doctors, setting appropriate AL 90 AN GO M treatment goals, and utilizing evidence-based prescriptions. 80 Audit Score (Out of 90) Figure 3. 70 Additional audit criteria were created that did not apply to all cases, since some 60 guidelines only apply to specific patient populations, (eg. referring for bariatric surgery The therapy most commonly used was nutritional supplementation (93%) followed 50 if Body Mass Index is over 35). Audit criteria that focused on naturopathic interventions by botanical medicine (69%). Other naturopathic modalities were rarely used to treat 40 and RSNC operations were also assessed. These included the recommendations for T2DM or its complications. Of the supplements, omega-3 fatty acids (mean dose: 30 various supplements, botanicals, physical medicine, homeopathy, Traditional Chinese 1818 mg daily) was the most common, followed by chromium (mean dose: 681 20 Medicine, therapeutic counseling and use of the Measure Yourself Medical Outcome mcg daily). 10 Profile (MYMOP) as a universal outcome measure of effectiveness of individualized Interns enter information into the NPD after a minimum of 3 patient visits. An 0 patient-defined symptoms. analysis was done to see how audit scores compared to the number of visits that 0 2 4 6 8 10 12 14 were omitted in the NPD. There were no differences among the audit scores, One auditor (CH) conducted a search of the NPD from May 2009 to February 2011 to NPD Visits Missing indicating that the quality of care was largely determined within the first 3 visits. identify patients assessed with T2DM. The assessment section of the NPD contains a column for diagnosis that uses the International Classification of Diseases, 10th revision (ICD-10) coding system. The inclusion criteria were all patients assessed with T2DM, so Discussion that the audit could also capture a realistic representation of naturopathic care for The audit scores evaluating the patient intake were high. This is likely because Feedback is key in improving audit scores and patient care. Audit findings those with comorbidities, as is often the case in patients with T2DM. The code for interns spend one hour per visit with patients and so have large amounts of time to were presented to clinical supervisors and to current clinic interns. They were T2DM (E11) was employed and captured 29 patient cases. accumulate information. The audit scores for lab tests were also high and this is also integrated into the curriculum. The poorest scoring categories were likely because naturopathic doctors in Ontario cannot directly requisition lab tests, so emphasized. A checklist was created to help guide interns in their first 3 visits Figure 1. Process of Case Selection for Audit. credit was given in the audit if an intern requested lab work from the patient. with a diabetic patient. Education and creation of a naturopathic standard of care may improve audit performance and patient outcomes for patients with The three lowest scoring categories in the audit were: a thorough physical exam, 13,824 39 T2DM 37 T2DM 29 T2DM T2DM. Larger scale follow-up audits are planned to examine the impact of Cases (May Cases With referring patient care, and setting specific treatment goals. The physical exam Total NPD Cases With audit feedback and continue the process of practice improvement. Cases (2006 2009 to Feb Complete Patient File component scored poorly because there are guidelines for T2DM that fall outside of to 2011) 2011) NPD Data Identifiers the RSNC’s screening physical exam form. Referring patient care scored poorly, in Selected References Acknowledgements part, because according to the American Diabetes Association, patients must be 1) American Diabetes Association Standards 1) Robert Schad Naturopathic Clinic 13,785 Excluded 2 Excluded 8 Excluded referred to many health care practitioners who’s capabilities often overlap with those of Medical Care in Diabetes 2010. 2) OM Corporation of NDs. Setting specific treatment goals likely scored poorly because there are no 2) Bradley R, Kozura E, Buckle H, et al. 3) Lotte and John Hecht Foundation current guidelines for naturopathic standards of care for diabetes. Collection and Description of Clinical Risk Factor Changes During Naturopathic Care for Type 2 Diabetes. 4) Diabetes Alternative Research and reporting of subjective outcomes (MYMOP) could be improved. Healthcare Foundation
  • 3. Evidence for the Topical Application of Castor Oil: A Systematic Review Deborah A. Kennedy ND1 and Dana Keaton ND LAC2 1Canadian College of Naturopathic Medicine 2Center for Natural Medicine Results Seventeen participants with “fatigue” were recruited to Background participate in an investigation of longer use of COPs. Castor oil, also known as Palma Christi, is derived from the Search Strategy Flow Chart Constipation Participants applied the COPs for 1.5 hours per day over the bean of the plant Ricinus communis, through cold mechanical 462 articles found Researchers Arslen and liver area for 5 days per week for 2 weeks. During the course of pressing. Ricinus communis is native to India and during initial search Eser evaluated the treatment, the mean total lymphocyte counts normalized within (July 2009) approximately 90% of the oil is produced in Brazil and India. 400 articles rejected effectiveness of COPs on the group and were lower at the end of treatment vs baseline. Castor oil is composed chiefly of ricinoleic acid, which based on title review constipation in 35 elderly As an unexpected outcome, 2 participants with elevated liver 62 abstracts screened represents approximately 80 - 90% of the total fatty acid for inclusion nursing home residents. enzymes and cholesterol levels normalized these variables by content. Castor oil has been used since the 16th century BC Constipation symptoms the end of the study. in many forms. It can be taken internally, used topically and 10 articles retrieved for were tracked for 14 days incorporated into cosmetics and drug delivery systems. It is full analysis using the Defecation Pain Reduction the evidence associated with the topical application of castor Search re-executed (May 2011) 2 articles Monitoring form and Viera et al compared the anti-inflammatory and antinociceptive oil that is the focus of this review. 9 articles included in Visual Analog Scale, with effects of topical castor oil and capsaicin. Their findings systematic review COPs applied on Days 8, suggest that castor oil is devoid of irritant properties, unlike 9 capsaicin. Ricinoleic acid was found to deplete substance P. Methodology Capsaicin is used to treat neuropathic pain and the authors and 10. Findings included improvements in evacuation, fecal suggest that castor oil maybe as effective as capsaicin, without PubMed, Embase, Alt-Med and CINAHL databases were consistency and a reduction in straining. There were no its irritating properties. searched using the terms castor oil/therapeutic use, changes to the frequency of bowel movements nor the ricinoleic acid and Ricinus communis/therapeutic use, not amount of feces evacuated. Discussion ricin, from inception to July 2009 and updated May 2011. For Artifical Tears Both castor oil and its main constituent, ricinoleic acid, have inclusion in the review, articles had to be related to the A double-blind placebo-controlled crossover study by Goto et been found to be non-toxic for both internal and external use. topical use of castor oil. Articles dealing with castor oil used al evaluated low-dose castor oil eyedrops, or artificial tears in Case reports in the literature document evidence of contact in manufacturing, as a food additive, or as a cathartic were 20 patients with obstructive meibomian gland dysfunction. dermatitis from castor oil in cosmetic products. excluded, as was the use of castor oil to aid in the delivery of Treatment with castor oil demonstrated improvement in Historically, castor oil has been reputed to provide relief for pharmaceutical drugs. symptoms and objective findings. Maissa et al also found that dermatologic conditions, contusions, inflammatory and ocular eyedrops containing castor oil produced a more stable tear disorders. This review disclosed no cohesive evidence regarding Results film and a significant decrease in ocular dry eye symptoms. the mechanism of action of castor oil or its main constituent, Nine studies investigated the topical use of castor oil ricinoleic acid. Immune and Liver function through direct application of the oil or in the form of castor Preliminary evidence suggests that castor oil may modulate A double-blind controlled study of a single use of COPs vs oil packs (COPs). white blood cell count and may have a positive effect on liver paraffin oil packs in 36 healthy adults found an increase in Transdermal Absorption function and cholesterol levels; further research is needed in this total lymphocytes which peaked at 7 hours with T11 cells Mein et al conducted a small study to assess castor oil area. The topical application of castor oil has been shown to contributing to the overall increase. COPs were applied over absorption through the skin vs oral intake. A 2-phase study reduce the pain of neurogenic inflammation, improve symptoms the liver and abdomen for 2 hours with heat. At the 24-hour comparing abdominal COPs for 3 consecutive days versus of constipation and to lubricate the eyes as artificial tears. mark, total lymphocytes declined, although they remained oral consumption found no significant difference in the within normal limits. urinary metabolites of castor oil pre- and post-COP while Acknowledgements. significant differences were found pre- and post-oral intake. Deborah Kennedy’s efforts on this project were supported by a career development grant from the SickKids Foundation.
  • 4. Xenoestrogens & Breast Cancer: Chemical Risk, Exposure and Social Determinants Sarah Young, MA (1) & Dugald Seely, ND, MSc, FABNO (1,2,3) 1. Ottawa Integrative Cancer Centre 2. Department of Research & Clinical Epidemiology, Canadian College of Naturopathic Medicine, Toronto 3. Ottawa Hospital Research Institute Medicine, Background Xenoestrogens and Breast Cancer Incidence of breast cancer has risen in Canada by more than 25% Table 1: Common Xenoestrogens, sources and effects over the past twenty-five years, is the leading cause of death in Xenoestrogens are chemicals that women aged 20-44, and comprises over thirty percent of all cancer mimic the effects of estrogen due to XENOESTROGENS FOUND IN EFFECTS diagnoses in women. Nearly two-thirds of breast cancer cases result structural chemical similarities. As from a combination of gene-environment interactions, lifestyle opposed to endogenous hormones, Bisphenol A (BPA) bottles, tin cans, drink containers, In vitro and animal studies: water pipes, dental composites, optical neoplastic development, factors (including lack of physical exercise, alcohol intake, and xenoestrogens come from sources lenses, adhesives, compact discs, paper proliferation of epithelial cells, coatings expression of estrogen receptors obesity), and exposure to environmental pollutants. Exposure to external to the body. Like other (ERs) and progesterone receptors (PRs), and a decreased vaginal estrogen is the most important identifiable risk factor responsible endocrine disruptors, xenoestrogens weight, transgenerational for the development of breast cancer. While endogenous estrogen is can alter normal hormonal function, amplification. clearly important, the contribution that xenoestrogens have on producing adverse health effects for Polychlorinated electrical equipment, plasticizers in Human studies: high levels found breast cancer causation is just starting to be documented. both adults and their children. Biphenols (PCB’s) paints, plastics, and rubber products, pigments, dyes, and paper. Though in breast milk of northern communities banned in 1979 PCBs are still released PCBs are now regularly found in Mammary tissue cells express specific into the environment from hazardous waste sites. PCBs do not readily break mammals and ocean wildlife in the far north Chemicals in Our Environment receptors, known as alpha-receptors down and remain for long periods of time recycling between the air, water, that can be stimulated by estrogens to and soil. There are over 80,000 synthetic chemicals in and around us: they are induce the proliferation of end buds in Certain Pesticides used extensively in agriculture, in In vitro and animal studies: sprayed directly on our food in the form of pesticides; they get the breasts. Proliferation of these end (i.e. DDT, heptachlor, atrazine, chlordane, homes, in workplaces, and throughout cities on private and public lawns immunotoxic, mutagenic, carcinogenic, enhances the pumped into the air by diesel exhaust and industrial emissions in the buds increases the risk of breast aldrin, lindane, 2,4,5-TP and the captans) metabolism of other xenobiotic chemicals form of polycyclic aromatic hydrocarbons (PAHs); they are used as cancer by augmenting the chance of Occupational studies: women working in agriculture 3 times liners in tin cans, are built into plastic water bottles and are found in mutation during cell division. more likely to have breast cancer dental composites in the form of bisphenol A (BPA); are added to There are over 200 xenoestrogens used in industry, cosmetics, Cadmium from burning fossil fuels and In vitro and animal studies: personal care products in the form of parabens; leach into the soil agriculture and food processing that act as mammary carcinogens municipal waste, the smelting of zinc and copper, and tobacco smoke. induction of single-strand DNA breaks, inhibition of DNA repair and water from electronic waste in landfills in the form of cadmium, Cadmium is used in electroplating, in by inactivation of the mismatch and have been found in over 95% of human tissue. Twenty-nine of alloys, as a de-oxidizer in nickel repair system, activation of and are found in high amounts in the fish we eat as polycyclic plating, in Cd-Ni batteries, as oncogenes, inhibition of these compounds are produced at over a million pounds per year pigments in glazes and enamel paints, programmed cell death biphenols (PCBs). in plastics, and in fertilizers. Parts of (apoptosis). in the USA. North America are known to have high levels of cadmium in the soil. Occupational studies: Women working in automotive were 4 Since the 1950’s more than 750 million tons of toxic chemical waste times more likely to have breast cancer. have been discarded across 50,000 hazardous waste sites in the Relevant Social Determinants United States alone. Among all North American jurisdictions, Ontario Parabens, Pthalates Personal care products, including Breast cancer rates amongst Exploring the impact of xenoestrogens from a social determinants shampoos, creams, conditioners, African American women under is the fourth highest emitter of cancer causing chemicals into the air, hairsprays, deodorants, cosmetics, and age 30 are 50% higher than white of health model, we found that early life, food security, social perfumes women and their use of estrogenic emitting over four million kilograms of reproductive toxins each year. personal care products is ten exclusion, education, working conditions, income, housing, and times higher Xenoestrogens consist of a class of endocrine disrupting chemicals availability of a social safety net had a significant impact on the Polycyclic Aromatic fossil fuel combustion, diesel exhaust, In vivo, in vitro and human (EDCs) that have causative links to cancer and particularly to breast risk of exposure. These issues speak directly to breast cancer Hydrocarbons (PAH’s) consumption of smoked and grilled foods, and from cigarette smoking studies: mutagenic, increased proliferation of cells, effects on cancer. Common xenoestrogens include Bisphenol A, PCB’s, risk and chemical exposure and inequities in society as well as the estrogen receptors, enzymes of the CYP 450 family and on the Cadmium, Pesticides, PAHs, Parabens and Pthalates (see table on issue of vulnerability. The timing of exposure to increased levels of tumour suppressing gene right for more detail and examples). both natural and chemical xenoestrogens in a woman’s body, embryo, fetus, and infant plays a key role in the development of Acknowledgements. This review was funded by the National cancer. Network on the Environment and Women’s Health
  • 5. An observational study of adjunctive cancer care at the Canadian College of Naturopathic Medicine Gillian Flower ND1, Natalie Bozinovski ND(c)1, Gabriella Chow ND1, Kieran Cooley ND1, Martha Grant ND1, Christopher Habib ND1, Daniel Lander ND, FABNO1, Tara O’Brien ND1, Jill Shainhouse ND, FABNO1, Dugald Seely ND, FABNO1,2. O’ 1. Canadian College of Naturopathic Medicine; 2. Ottawa Hospital Research Institute Table 1. Select patient characteristics by cancer type Diet, lifestyle and mind-body interventions were common, as Background was individualized homeopathy, tinctures and teas. Mean age at % reporting The Adjunctive Cancer Care (ACC) shift provides Primary cancer Female / Number of Analysis of EORTC, MYCAW, MYMOP and KI showed that diagnosis – years conventional naturopathic care to patients with cancer at the Robert type male patients scores improved or were unchanged more frequently than (range) care pre-RSNC Schad Naturopathic Clinic (RSNC), the teaching clinic of the Breast 31 / 0 31 49 (30-76) 80.6 they worsened (Figure 1). This was true across all scores and Canadian College of Naturopathic Medicine (CCNM). This Digestive1 17 / 10 27 55 (2-83) 88.9 subscores in all measures used. The subset of eligible cross-sectional, observational study summarizes Prostate 0 / 20 20 61 (48-79) 40.0 responses per tool was small (n= 11-30) although 39.1% of demographic, outcome and treatment data for patients all charts yielded eligible responses for at least 1tool. Hematologic 8/6 14 45 (23-63) 78.6 seen on the ACC over a 13-month period. Female reproductive2 13 / 0 13 52 (26-71) 100.0 The 5 most common patient-identified concerns, elicited Neurologic 4/5 9 21 (0-67) 88.9 through MYCAW use included: references to cancer, to pain Methodology Head and neck3 5/2 7 53 (32-74) 85.7 or discomfort, to energy or fatigue, to weight or Other4 9/8 17 54 (33-83) 47.1 nutrition or to gastrointestinal symptoms. 84.2% of Point-of-sale software was used to identify patients that had evaluated patients named at least one of these 5 concerns. been seen on the ACC from December 2009-December 1 – Colorectal, hepatic, pancreatic, gastric; 2 – ovarian, uterine, vaginal; 3 – salivary, oral, thyroid, sinus; 4 – includes lung, skin, testicular, osseous, diverse types not included elsewhere 2010. The in-house Naturopathic Patient Database (NPD) was consulted for patient information, but a lack of 18% of patients reported a refusal of conventional treatment at some point, Discussion sufficient data led to a full patient chart review. many having tried chemotherapy or radiation previously. 9 deaths (6.5%) A diverse range of patients and cancers (type and stage) are Patients were included if they had a diagnosis of cancer and were confirmed. seen by student interns on the ACC at the RSNC. Treatments had >1 visit on the ACC. 35 data points were collected in include supplemental, lifestyle and dietary therapies and reflect 51% of all patients received intravenous vitamin C therapy (IVC), with use a blend of cancer-focused and individualized care. addition to scores on 4 validated assessment tools: the ranging from 45%-71% across various cancer types. Far fewer patients Karnofsky Index (KI), the Measure Yourself Medical with neurologic cancers received IVC (11%), but only 4 patients in this Patient-defined symptoms commonly include concerns with pain Outcomes Profile (MYMOP), the Measure Yourself Concerns group were eligible to receive this treatment in Ontario (>13 years old). and energy. EORTC results show fewer patients worsening in and Wellbeing scale (MYCAW) and the European these subscores than the number that maintain their current Organization for Research and Treatment of Cancer quality Oral supplementation was recommended in 98.5% of patients that had at status or improve. Other patient- and intern-based assessments of life questionnaire (EORTC). Intern prescriptions were also least 1 consult-type visit. All supplemented patients were given at least one of symptoms and function include the MYCAW, MYMOP and KI. counted. of the following 5 prescriptions: Vitamin D, curcumin, EGCG, All suggest a trend towards patient stabilization or improvement melatonin and fish oil. in evaluated outcomes. Results Figure 1. Percent of patients improving, not changing and worsening according to EORTC(1-5), MYCAW (6-7) and Karnofsky (8) results (>27 days of evaluation). Some limitations to this study include the small amount of eligible data for each tool. Responses were included if the same 189 patient charts were reviewed and 138 met criteria for tool was used on more than 1 occasion and if the time elapsed inclusion. 64% of patients seen were female. Breast cancer 100% between administration was >27 days yielding as few as 11 was the most common diagnosis, seen in 22.5% of all 80% responses in one instance. The original goal of using the NPD as cases. Mean age at diagnosis was lowest among neurologic Worsened a source of data could not be met, necessitating a chart review. cancers where 5/9 patients were 3 years of age or 60% Unchanged younger. Short- and long-term naturopathic care may successfully 40% Improved address some of the most important concerns of individuals Table 1 summarizes select patient characteristics. with cancer. Further research investigating patient experiences 20% and comparative effectiveness of naturopathic treatment of Average duration of care was 298.4 days (range 2-2163), 0% cancer are warranted. with an average of 7.4 (0-70) consult-type visits per patient. 51.5% of all patients had conventional treatment (surgery, l  ky  1 ue ain g e lth na ein Acknowledgements: tiv rn fs ig chemotherapy, radiation or other) during the course of their ea  P io no ni ce at lb 4. ot l H Our thanks to the interns of the ACC shift 2009- og on el  F ar care at the RSNC.  Em ba  W 3.  C  K 2011 and the Lotte & John Hecht Memorial  C 5. 8. lo 6. 7. 1. Foundation.  G 2.