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Glucagonoma
1.
2. Glucagonoma is a very rare tumor of the
islet cells, exclusively localized in the
Pancreas, which leads to an excess of
the hormone glucagon in the blood.
Glucagonoma originates from the Alpha
2 cells of the Pancreas.
3. (1) Viklund, A. (Photographer). (2009). Mouse islet of langerhans immunostained
for glucagon. [Web Photo]. Retrieved from
http://biochemistryquestions.wordpress.com/category/hormones-q/
A glucagon secreting pancreatic tumor
(glucagonoma).
4. There is no particular race specifications.
The frequency in males and females is equal,
although greater incidences are reported in
females.
The average age it effects people is 55 years
old but has been seen between the ages of
19-84.
Very rare- There has only been 2705 recorded
cases of endocrine pancreatic tumors in the
U.S. over a 28 year period ending on January
1, 2003. Glucagonoma with islet cell
neoplasm's accounting for only 1.3% of
pancreatic cancer.
5. Occurs exclusively in the Pancreas, but cancer
cells can spread to the Liver.
Rash on the Head
Shoulders
Knees
And Toes
Typically targets feet, abdomen, buttocks, face,
and legs.
But not until we say so.
6. (2, 3, 4) Jackson, L. (Photographer). (2009). Glucagonoma. [Web
Photo]. Retrieved from http://drugster.info/ail/pathography/1367/
A crusty or scaly rash that occurs all over the body. It may
also be raised sores or lesions filled with clear fluid or pus.
7. The cause is unknown
But, a family history of the syndrome
multiple endocrine neoplasia type one,
which is a tumor syndrome, is a risk
factor
8. Glucagon overproduction
Diarrhea
Excessive thirst
Frequent urination
Increase in appetite
Inflamed mouth and tongue
Night time urination
Skin rash that comes and goes
Unintentional weight loss
High blood pressure
Glucose intolerance
Some cases lead to depression
9. The cancer can spread to the liver
High blood sugar levels can cause metabolic
problems
Tissue damage
High rate of Thromboembolitic complications
(blood clot)
Pulmonary embolisms
10. Surgery to remove the tumor
Usually doesn’t respond to chemotherapy
Currently, there are no drugs used to treat
Glucagonoma
Providing a supplemental protein supply in order
to furnish amino acids is useful
Administration of fatty acids and minerals is also
useful
11. Approximately 60% of tumors are
malignant
If it is contained in the pancreas, the
person has approximately a 5 year survival
rate of 85%
Some patients live over 20 years without
therapy if benign
12. (5,6) Martinez, I. (Photographer). (2005).
Glucagonoma and necrolytic migratory erythema.
[Web Photo]. Retrieved from
http://scielo.isciii.es/scielo.php?pid=S1130-
01082005000600008&script=sci_arttext
Severe skin rash in a 54 year old male who also suffered
from severe weight loss. The skin rash cleared within a
week after the operation and the patient remains free of
disease at 38 months following surgery.
13. (7) McGevna, L. (Photographer). (2010). Glucagonoma. [Web Photo].
Retrieved from
http://endocrinediseases.org/neuroendocrine/glucagonoma.shtml
The rash develops in about 70% of patients, often
before other symptoms arise. The skin condition
commonly begins as red lumps and plaques in the
perineum (the area between the genitals and
anus), groins, or abdomen, and it may migrate to
the extremities.
14. Image (1) Viklund, A. (Photographer). (2009). Mouse islet of langerhans
immunostained for glucagon. [Web Photo]. Retrieved from
http://biochemistryquestions.wordpress.com/category/hormones-q/
Image (2, 3, 4) Jackson, L. (Photographer). (2009). Glucagonoma. [Web Photo].
Retrieved from http://drugster.info/ail/pathography/1367/
Image (5,6) Martinez, I. (Photographer). (2005). Glucagonoma and necrolytic
migratory erythema. [Web Photo]. Retrieved from
http://scielo.isciii.es/scielo.php?pid=S1130-
01082005000600008&script=sci_arttext
Image (7) McGevna, L. (Photographer). (2010). Glucagonoma. [Web Photo].
Retrieved from http://endocrinediseases.org/neuroendocrine/glucagonoma.shtml
Dugdale, D. (2010, December 28). Glucagonoma. Retrieved from
http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001367/
WebMD. (2011, May 23). Glucagonoma. Retrieved from
http://emedicine.medscape.com/article/118899-overview
A.D.A.M. (2012, February 7). Glucagonoma. Retrieved from
http://www.nlm.nih.gov/medlineplus/ency/article/000326.htm
Kahn, D. (2011, June 3). Glucagonoma. Retrieved from
http://www.uptodate.com/contents/glucagonoma-and-the-glucagonoma-
syndrome