1. Course = VPAT- 801 Submitted to: Dr. D. V. Joshi Professor and Head, Veterinary Pathology Department, Sardarkrushinagar Dantiwada Agricultural University, Submitted by: Chirag M. Modi Reg. no.- 04-0442-08

7. Primary union ( healing by 1st intention) -Healing of a clean linear wound /surgical incision with sligth damage of tissues  space fills with clotted blood  24 hs:PMN´ mitoses of basal epithelium  dehydration at surface  scab Primary Intention

10. Primary union(cont.) A. 1-2 days  epithelial cells grow along cut surface B. 3 days  macrophages /granulation tissue C. 5 days  space filled /granulation tissue D. 2nd wk.  accumulation of collagen, fibroblasts E. End of 1st month  connective tissue devoid of inflammation, epidermis restored F. Tensile strength increases 70-80% of unwoun ded skin in 3 months

11. means the healing of a wound where there is a more extensive of tissue that has gradually to be filled in and replaced by new connective tissue. Healing by second intention

14. Within a few weeks, the rapidly dividing epidermis completely lines the original wound site. The fibroblasts generate new connective tissue (scar tissues), which replaces the epidermis destroyed by the wound. Scar tissue persists after the healing of particularly severe wounds .

18. Phases of wound healing sequence Coagulation Inflammation Migration/Proliferation Angiogenesis Epithelization Contraction Fibroplasia Remodeling

19. Schematic Diagram of the Phases of Wound Healing

26. Its histologic appearance is characterized by proliferation of fibroblasts and numerous new thin-walled, delicate capillaries edema and a loose ECM containing occasional inflammatory cells.

27. Cytokines play an important role in the evolution of granulation tissue through recruitment of inflammatory leukocytes and stimulation of fibroblasts and epithelial cells.

32. Factor affecting wound healing Systemic factor Nutrition Vitamin-C Zinc Age Glucocorticoids Local factor Ischemia Foreign body Mechanical factor

35. - CNS  gliosis ( may cause hydrocephalia) -PNS  neurons can regenerate their axons in ideal conditions, but lack of alignment or inflammation  traumatic “neuroma” (Schwann cells+fibroblasts ) -Lungs  interstitial pulmonary fibrosis or peribronchial fibrosis  bronchectasis -Pleura  pleural fibrosis/adhesions(TB ) HEALING IN SPECIFIC TISSUES

36. -Stomach  fibrous stenosis of pylorus (gastric ulcer) -Rectosigmoid  fibrous stenosis due to ven. diseases -Liver  cirrhosis -Fallopian tubes  fibrous occlusion due to P.I.D. -Skin  contracture / deformation(burns) HEALING IN SPECIFIC TISSUES(cont)

37. -Myocardium  fibrosis  ventricular aneu- rysm -Endocardium  valvular fibrosis +deformat. -Pericardium  constrictive pericarditis,peri cardial adhesions -Peritoneum  adhesions and fibrous bands -Esophagus  fibrous stricture(due to burns) HEALING IN SPECIFIC TISSUES(cont)

39. Sloughy wound

40. Necrotic wound

41. Granulating wound

42. Infected wound

43. Epithelialising wound

44. Thank you