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Pathophysioliogy of
     Intestinal
    obstruction
           Chirantan Mandal
      3rd MB Proffessional part II
Dept of Surgery, Medical College Kolkata
Intestinal obstruction
• Dynamic - peristalsis is working against a
  mechanical Obstruction

• Adynamic -
  absent peristalsis (Paralytic ileus)
  non-propulsive peristalsis form
Changes proximal to Bowel obstruction
  Intestinal Obstruction & Increased Peristalsis



            Obstruction not relieved



                  Peristalsis ceases
        Fluid collection Proximal to obstruction
          (Bacterial multiplication and Toxaemia)




        Flacid, paralysed, dialated Bowel
                  Inflammation (bowel Wall)
         Cytokine releasing Macrophages Accumulates
         Increased release of NO with ROS production
Changes at site of Bowel obstruction
                   Venous Return Inpaired
increased intraluminal pressure exceeding bowel wall venous pressure


                Congestion & edema of Bowel
               Further Dialatation & Ischaemic Injury
               Involvement of Arterial Supply
                   Blockage of arterial perfusion
                       Loss of Peristalsis
                        Bowel wall necrosis




                            Gangrene
             Bacterial Toxin release & mucosal damage
                    Translocation to submucosa
                              Toxaemia
STRANGULATION
Closed-loop obstruction

Loop of Bowel obstructed at entry
and Exit point of a closed loop
i.e at proximal and distal loop of
bowel
Closed-loop obstruction




Gangrenous Bowel
External Hernia
Internal hernia
 portion of the small intestine becomes
 entrapped in the retroperitoneal fossae
 other Sites of Internal Hernia :-
• the foramen of Winslow
• a hole in the mesentery
• hole in the transverse mesocolon
• diaphragmatic hernia
transverse colon volvulus
                                                                                        Volvulus
                                                                                      Twist in axis of bowel




      loop type CV




                                      Each arrow on the diagram of the normal colon
                                      represents a possible torsion mechanism



 bascule type ceacal volvulus
(Constricting Band Around Ascending Colon)
  bascule = Sea Saw
loop type CV
Caecum distended and
found in centre of Abdomen
Compound
    Volvulus
& Ileosigmoidal
    Knotting
Intussusception
portion of the gut becomes invaginated
within an immediately adjacent segment

part that advances = apex
Mass = Intussusception
Neck =junction of the entering layer with the mass

strangulating obstruction as the blood supply of the
   inner layer

degree of greatest at ileocaecal valve

In children intussusception is ileocolic
(50cm terminaL Ileum)
In Adult colocolic intussusception is common
Obstruction by adhesions
       and bands
Causes
Obstruction by adhesions   • Ischaemic areas
                           • Reperitonealisation of raw areas
                           • trauma, vascular occlusion
                           • Foreign material Talc,
                           • Infection Peritonitis, tuberculosis
                           • Crohn’s disease
                           types –
                           • ‘avscular’ flimsy
                           • ‘poorly vascular’ dense
Obstruction by Bands




Strangulation of Bowel loops by Knotting Diverticulum
 Dense Fibrous String attaching one
 portion of abdo to other; entraping
 intestine into Strangulation
 Causes:-
 • following previous bacterial peritonitis
 • a portion of greater omentum
 adherent to the parietes.
Bolus obstruction
Gallstones Ileus
passage of a GBstone from the biliary tract
    into the intestinal tract (by fistulous
connection between the GB & duodenum)

    usual location is at or 60 cm proximal
            to the ileocaecal valve

  obstruction is frequently incomplete or
 relapsing as a result of a ball-valve effect.
Ascariasis
Obstruction of the small
       intestine
        due to
  Ascaris lumbricoides
Trychobezoars &
                  phytobezoars
                firm masses of undigested hair balls &
                    fruit/vegetable fibre

                associated with an underlying
                   psychiatric abnormality
 Phytobezoars
                                      Predisposition to
                                        phytobezoars
                                 • high fibre intake
                                 •inadequate chewing
                                 •previous gastric
                                 surgery
                                 • hypochlorhydria

Trychobezoars
Food Bolus obstruction
          • may occur after
            partial or total
            gastrectomy
          • when unchewed
            articles can pass
            directly into the small
            bowel.
          • Fruit and vegetables
            are particularly liable
            to cause obstruction
Stercolith       associated with
Faecal Impaction   Diverticulosis and
                     ileal stricture
Meconeum Ileus
Meconium becomes thickened and causes mechanical obstruction in ileum
(associated with cystic fibrosis )

Hypertrophy dialatation of Proximal Bowel
Distal ileum contains Pellets and gets narrowed
Congenital Intestinal
    Obstruction
Duodenal
Atresia



        Duodenal Stenosis          Fibrous cord Atresia




Complete Atresia With Separation
Most common site of Intestinal atresia

       Defective fusion of foregut and Midgut
           With failure of recanalisation




Associated with
1. Annular Pancreas
2. Down syndrome
3. Maternal polyHydroamnios
Fibrous Atresia


                                          Mucosal Atresia




                            Complete Single Atresia
                                                                         Complete jejunal Atresia
                            (Vshaped Mesentry)
                                                                         with Coiled Ileum
                                                                         (christmas tree deformity)
Gresifield Classification




                                                                                         Jejunoileal
                                                                                         Atresia
                                                      Multiple Atresia
Most common at prox. Ileum
 Proximal bowel:- dialated & hypertrophy
                    normal sized Villi
Distal bowel:- collapsed hypertrophied Villi
Malrotation
Small bowel in right side
colon on left side
Caecum suspended midline
Incomplete
     Rotation
Most common type

Caecym subhepatic Rt
hypochondrium

LADDs band connects to postr wall

LADDs compresses 2nd part of
Duodenum

Midgut hangs along SMA
Reverse Rotation

180deg clockwise
  rotation

Colon posterior to
  duodenum & SMA
Paralytic ileus
  (Adynamic )


  Intestine Fails to
  transmit any
  peristalsis due to
  failure of
  nueromuscular
  mechanism
  Auerbachs and
  Meissners Plexus
Thank You
Normal Rotation of Midgut
Strangulated Bowel due to Omental Adhesion

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Pathopyshiology of Intestinal Obstruction CHIRANTAN MANDAL Medical College kolkata

  • 1. Pathophysioliogy of Intestinal obstruction Chirantan Mandal 3rd MB Proffessional part II Dept of Surgery, Medical College Kolkata
  • 2. Intestinal obstruction • Dynamic - peristalsis is working against a mechanical Obstruction • Adynamic - absent peristalsis (Paralytic ileus) non-propulsive peristalsis form
  • 3. Changes proximal to Bowel obstruction Intestinal Obstruction & Increased Peristalsis Obstruction not relieved Peristalsis ceases Fluid collection Proximal to obstruction (Bacterial multiplication and Toxaemia) Flacid, paralysed, dialated Bowel Inflammation (bowel Wall) Cytokine releasing Macrophages Accumulates Increased release of NO with ROS production
  • 4. Changes at site of Bowel obstruction Venous Return Inpaired increased intraluminal pressure exceeding bowel wall venous pressure Congestion & edema of Bowel Further Dialatation & Ischaemic Injury Involvement of Arterial Supply Blockage of arterial perfusion Loss of Peristalsis Bowel wall necrosis Gangrene Bacterial Toxin release & mucosal damage Translocation to submucosa Toxaemia
  • 6. Closed-loop obstruction Loop of Bowel obstructed at entry and Exit point of a closed loop i.e at proximal and distal loop of bowel
  • 9. Internal hernia portion of the small intestine becomes entrapped in the retroperitoneal fossae other Sites of Internal Hernia :- • the foramen of Winslow • a hole in the mesentery • hole in the transverse mesocolon • diaphragmatic hernia
  • 10. transverse colon volvulus Volvulus Twist in axis of bowel loop type CV Each arrow on the diagram of the normal colon represents a possible torsion mechanism bascule type ceacal volvulus (Constricting Band Around Ascending Colon) bascule = Sea Saw
  • 11. loop type CV Caecum distended and found in centre of Abdomen
  • 12. Compound Volvulus & Ileosigmoidal Knotting
  • 13. Intussusception portion of the gut becomes invaginated within an immediately adjacent segment part that advances = apex Mass = Intussusception Neck =junction of the entering layer with the mass strangulating obstruction as the blood supply of the inner layer degree of greatest at ileocaecal valve In children intussusception is ileocolic (50cm terminaL Ileum) In Adult colocolic intussusception is common
  • 15. Causes Obstruction by adhesions • Ischaemic areas • Reperitonealisation of raw areas • trauma, vascular occlusion • Foreign material Talc, • Infection Peritonitis, tuberculosis • Crohn’s disease types – • ‘avscular’ flimsy • ‘poorly vascular’ dense
  • 16. Obstruction by Bands Strangulation of Bowel loops by Knotting Diverticulum Dense Fibrous String attaching one portion of abdo to other; entraping intestine into Strangulation Causes:- • following previous bacterial peritonitis • a portion of greater omentum adherent to the parietes.
  • 18. Gallstones Ileus passage of a GBstone from the biliary tract into the intestinal tract (by fistulous connection between the GB & duodenum) usual location is at or 60 cm proximal to the ileocaecal valve obstruction is frequently incomplete or relapsing as a result of a ball-valve effect.
  • 19. Ascariasis Obstruction of the small intestine due to Ascaris lumbricoides
  • 20. Trychobezoars & phytobezoars firm masses of undigested hair balls & fruit/vegetable fibre associated with an underlying psychiatric abnormality Phytobezoars Predisposition to phytobezoars • high fibre intake •inadequate chewing •previous gastric surgery • hypochlorhydria Trychobezoars
  • 21. Food Bolus obstruction • may occur after partial or total gastrectomy • when unchewed articles can pass directly into the small bowel. • Fruit and vegetables are particularly liable to cause obstruction
  • 22. Stercolith associated with Faecal Impaction Diverticulosis and ileal stricture
  • 23. Meconeum Ileus Meconium becomes thickened and causes mechanical obstruction in ileum (associated with cystic fibrosis ) Hypertrophy dialatation of Proximal Bowel Distal ileum contains Pellets and gets narrowed
  • 24. Congenital Intestinal Obstruction
  • 25. Duodenal Atresia Duodenal Stenosis Fibrous cord Atresia Complete Atresia With Separation
  • 26. Most common site of Intestinal atresia Defective fusion of foregut and Midgut With failure of recanalisation Associated with 1. Annular Pancreas 2. Down syndrome 3. Maternal polyHydroamnios
  • 27. Fibrous Atresia Mucosal Atresia Complete Single Atresia Complete jejunal Atresia (Vshaped Mesentry) with Coiled Ileum (christmas tree deformity) Gresifield Classification Jejunoileal Atresia Multiple Atresia
  • 28. Most common at prox. Ileum Proximal bowel:- dialated & hypertrophy normal sized Villi Distal bowel:- collapsed hypertrophied Villi
  • 30. Small bowel in right side colon on left side Caecum suspended midline
  • 31. Incomplete Rotation Most common type Caecym subhepatic Rt hypochondrium LADDs band connects to postr wall LADDs compresses 2nd part of Duodenum Midgut hangs along SMA
  • 32. Reverse Rotation 180deg clockwise rotation Colon posterior to duodenum & SMA
  • 33. Paralytic ileus (Adynamic ) Intestine Fails to transmit any peristalsis due to failure of nueromuscular mechanism Auerbachs and Meissners Plexus
  • 36.
  • 37. Strangulated Bowel due to Omental Adhesion