MULTIDISCIPLINRY NATURE OF THE ENVIRONMENTAL STUDIES.pptx
New Insight Into the Human Genome Through the Lens of Evolution and decode Mystery Sequences Involved in Gene Regulation.
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4. Thanks to advancing technological age in which we
live today, it is possible that the field of research has
taken such force, such as molecular biology and his
constant study of the sequences involved in gene
regulation to give as result the main carrier of such
information: DNA.
DNA is the starting point for the perfect compression
of human functioning, demonstrated by comparison
of genetic information between men of the past and
those of us in the present. finding vital changes that
help the study of various pathologies.
This important molecule has been used for the
diagnosis and treatment of many diseases, so it is vital
to speak and learn about structure and interaction
with other components of the human body, hoping
each time finding new alternatives that benefit
humans.
5. A new study shows that possibly
up to 30% of DNA , is also
conserved at the level of RNA
structure, through a process
known as 'transcription‘.
6. DNA is a biological blueprint that must be copied into
another form before it can be actualized. Through a
process known as 'transcription', DNA is copied into
RNA, some of which 'encodes' the proteins that carry
out the biological tasks within our cells. Most RNA
molecules do not code for protein, but instead
perform regulatory functions, such as determining the
ways in which genes are expressed.
7. Dr Martin Smith and Professor
John Mattick, from Sydney's
Garvan Institute of Medical
Research, devised a method
for predicting these complex
RNA structures, At the same
time, they matched
mutations found in the
genomes with consistent
RNA structures.
8. Many RNA transcripts are associated with diseases
and developmental conditions, this is the first step.
The next is describe the relate to our normal
development and to disease.
9. It's really amazing how DNA and
RNA are the basis of many human
body pathological explanations
given by the evolution of their
studies. Is important stand out as
will be possible in the future
diagnosis and treatment of
diseases from the same DNA line
before transcrip into RNA,
becoming a therapeutic method
with benefits for humans.
10. Scientists know that much of what
a gene does and produces is
regulated after it is turned on. A
gene first produces a molecule
called RNA, to which tiny proteins
called RNA binding proteins (RBPs)
bind and control its fate. For
instance, some of these proteins
cut out parts of the RNA molecule
so that it makes a particular
protein, while other RBPs help
destroy the RNA before it even
produces a protein.
11. The mechanisms that may benefit or affect RNA chain
are not well known, have been difficult to decipher. To
understand this regulation is necesary advanced
laboratory techniques to identify patterns of RNA
sequences
12. This motivate Tim
Hughes (University of
Toronto and the
Canadian Institute for
Advanced Research) to
produce the first
compendium of RNA-
binding sequences with
a modern advanced
laboratory techniques.
13. Was a long study that needed many years finding
complexes that bind specifically to the RNA at the
end of its transcription and cause dysregulation in
gene expression, generating many diseases such as
autism. Therefore its study is useful.
14. Its very interesting to see how since
the search of complexes that bind
to RNA different diseases can be
diagnosed as autism example of
this investigation, but it is still more
interesting because knowing these
sequences are targeted to
produce medicines and treatments
to help to the correction of these
genes prevents pathologies own
treating them from the genetic line.
15. Medical Utility
Its very important for
medicine because open
a big therapeutic field,
treating of diseases in
the DNA own chain.
16. Medical Utility
Its very interesting for
medicine, with the study of
the genome can be
discovered genetic disorders
that result in changes in
behavior or physical
appearance in humans
before born.
17. Medical Utility
For medicine is very useful to
know which specific complex
is causing damage, so that it
acts directly on the fault,
preventing accidental cause
any damage to the patient
but with a benefit the cure of
the disease.
18. Medical Utility
Be able to identify specific
abnormalities in a DNA
laboratory exam and warn of
the possible consequences
that the patient can have for
this damage.
19. References
MARTINEZ SANCHEZ, Lina María.
Biología Molecular. 7 ed. Medellín:
UPB. Facultad de Medicina. 2013.
New Insight Into the Human Genome
Through the Lens of Evolution. [on line]
Science daily. July 11, 2013.
.Scientists Decode Mystery Sequences
Involved in Gene Regulation. [on line]
Science daily. July 10, 2013