Tuberculosis in Infancy & Chidhood
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Tuberculosis in Infancy & Chidhood PPS guideline on TB in Infancy & Childhood 3rd edition 2010
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Tuberculosis in Infancy & Chidhood
- 33. Initial Empiric Therapy of Tuberculosis in Infants, Children and Adolescents Class III (active TB Disease) New smear (-)PTB Less form of extra PTB New smear(+) PTB New smear(-) PTB w/ extensive parenchymal involvement Severe extrapulmonary TB Severe concomitant HIV disease TB Meningitis Bone joint TB Intensive 2 months HRZ once daily 2HRZE 2HRZS 2hrzs Continuation 4 months HR given once daily or 6 months HE 4HR or 6HE 4HR 7-10 HR
- 34. Class III (active TB Disease) Previously treated smear(+) PTB; relapse tx after interruptiontx failure Chronic MDR and XDR - TB Intensive 2HRZES/ 1HRZE Specially designed/ standardized regimens Continuation 5HRE
Notes de l'éditeur
- While it is considered a disease of the urban poor today, tuberculosis has claimed the lives of numerous noted personalities around the world through the centuries. The most famous Filipino who contracted and later died of tuberculosis is probably Manuel L. Quezon, the first President of the Philippine Commonwealth. According to the WHO, >2 Billion people – one third of the world’s total population – are infected with TB bacilli. One in every 10 of those people will become sick with active TB in his lifetime. A total of 1.77 million people died from TB in 2007 (including 456,000 people with HIV), equal to about 4,800 deaths a day. The Philippines is among the 22 high burden countries for tuberculosis, according to the WHO. TB is the 6th leading cause of illness and the 6th leading cause of deaths among Filipinos. According to the 2nd National Prevalence Survey done in 1997, most TB patients belong to the economically productive age-group (15-54 years old).
- When the infectious droplet nuclei are inhaled & reached the terminal air passages.
- The time bet entry & the development of tissue hypersensitivity manifested as reactive tuberculin skin test
- Establishing a definite dx of childhood TB is difficult because specimens are hard to obtain& contain few mycobacteria leading to delays in treatment or overdiagnosis.