2. 1 Organ that controls 6 vital functions of the body
Removes poisonous substances
Helps in digestion
Stores Energy
Purifies Blood
Manufactures new proteins
Processes Food

3. Liver functions continued....

4. Liver functions continued....

5. Did you Know.... ???
 The Liver is the Largest internal Organ & Largest gland in the human body.
 The human Liver weighs approximately 3.5 – 5.5 lbs.
 Alcohol abuse is the most common cause of liver disease in India.

6. Common Diseases of Liver
HEPATITIS: Inflamation of Liver caused due to Viral Infections. Its of three types.
CIRRHOSIS: Fibrosis of Liver tissues characterized by loss of Liver Function.

8. Launching Dabur Hepano – Everyday care for Liver
For everyday Liver Health

9. DABUR HEPANO
• Enriched with Herbs like
Bhumiamlaki, Guduchi, Nimba,
Haritaki, Kalmegh etc.
PRODUCT
• Pre Clinical studies have shown
significant Hepato protective
Action. Reduces SGOT, SGPT and
Serum bilirubin levels to normal
KEY DIFFERENTIATOR
• 200 ml Pack with Monocarton
• 30 Units in one Case.
• Pack comes with QR code.
PACKAGING
PRICING • MRP : Rs.85/-.

10. DABUR HEPANO – BRAND DETAILS

11. DABUR HEPANO – COMPOSITION
Bhumiamalaki Baheda Guduchi
Amla
Harad
Pippali Nimba
Kalmegh
Kutki

12. Bhumyamlaki (Phyllanthus niruri)
Parts used: Whole plant
Properties:
Taste inducer (Rocana) , useful in Amlapitta (Hyperacidity), Pandu (Anaemia), Hepato-splenomegaly
and Jaundice.
Scientific studies: Hepatoprotective acitivity on nimesulide- induced oxidative stress
in vivo etc

13. Guduchi (Tinospora cordifolia)
Parts used: Stem
Properties:
Strength promoting (Balya), Digestion promoter (Dipana), Rejuvenator (Rasayana),
Blood purifier (Raktasodhaka), useful in Jaundice (Kamala)and Anaemia (Pandu)
Scientific studies: Hepatoprotective acitivity by modulation of kupffer cell activity by
in liver damage, in CCl4 intoxicated mature albino rats etc

14. Neem (Azadirachta indica)
Parts used: Bark
Properties:
Neem is used for tastelessness conditions. It is having anti-parasitic, anti-inflammatory, anti-ulcer
and hepato-protective effects.
Scientific studies: Hepatoprotective acitivity paracetamol-induced hepatic damage in albino
rats, against diethylnitrosamine (NDEA) induced hepatotoxicity in mice etc

15. Kalmegh (Andrographis paniculata)
Parts used: Whole plant
Properties:
Digestion promoter properties and is used in Ajirna (dyspepsia), Jvara (fever), Kandu (itching),
Kamala (jaundice) and Yakrtvikara (disorders of liver..
Scientific studies: Hepatoprotective acitivity in acute hepatitis induced by galactosamine &
paracetamol intoxication in rats, against against carbon tetrachloride-induced liver damage
etc

16. Haritaki (Terminalia chebula)
Parts used: Pericarp
Properties:
Rejuvenator, Antioxidant, Laxative. It is used as appetizer and is used in tastelessness
conditions, jaundice, hepato-splenomegaly, Anaemia etc.

17. Amla (Emblica officinalis)
Parts used: Fruit
Properties:
Mild purgative, agni deepak (Digestion promoter), Skin diseases, inflammation, It is a potent
Rasayana (Rejuvenating agent) and Bulk promoting (Brmhaniya)
Scientific studies: Amla possess hepatoprotective, antioxidant, cholesterol lowering property

18. Vibhitaki (Terminalia belerica)
Parts used: Pericarp
Properties:
Laxative, diuretic and cardio tonic treatments.
Scientific studies: Amla possess hepato-protective, antioxidant property

19. Kutki (Picrorhiza kurroa)
Parts used: Roots and Rhizomes
Properties:
Digestion promoter properties and is used in Jaundice and tastelessness conditions.
Scientific studies: Hepatoprotective action against subacute liver damages
induced by carbon tetrachloride etc

20. Pre-Clinical Efficacy Study
• Study drug: Hepano
• Pre clinical efficacy study conducted at Jamia Hamdard, Hamdard University, New Delhi
(Third party independent centre).
• Model used
– D-galactosamine induced Hepatotoxicity
– Paracetamol induced Hepatotoxicity
• New Livfit and Liv 52 were used as reference standards used in the study.

21. Pre-Clinical Efficacy Study
• Paracetamol caused hepatotoxicity in the toxicant group, elevated levels of SGOT,
SGPT, serum bilirubin, ALP as well as increased lipid peroxidation and significantly
reduced level of serum albumin and tissue glutathione compared to toxicant.
• Liv 52 and New Livfit significantly improved these parameters
• Hepano at 120 mg/kg and 240 mg/kg also showed significant improvement in
comparison to toxicant.
….contd
HEPATOPROTECTIVE ACTIVITY OF HEPANO

22. Pre-Clinical Safety Study
Study drug and duration: :
• Hepano was administered orally once daily for 28 consecutive days.
Results
• No mortality and clinical signs of toxicities were observed in all the treated
group animals and control group animals throughout the study period.
• Hematological investigation & blood biochemistry parameters were found to
be within the normal range both in treated and control groups.
• Gross pathological examination of all the animals did not reveal any
abnormality and the mean values of absolute & relative organ weights were
comparable to their respective vehicle control.
• Histo-pathological examination did not reveal any test item related changes.
• The no observed adverse effect level (NOAEL) of HEPANO when administered
orally once daily for a period of 28 days in both the sexes of Wistar rats was
found to be 1000mg/kg body weight.