1. R enal F ailure : acute, chronic &ESRD Saeed M.G. Al-Ghamdi, FRCPS,FACP Faculty of Medicine King Abdulaziz University Hospital

21. ARF: Causes Vasculitis & thrombosis & CAED ACEI & NSAID in predisposed patients Acute GN Severe cardiac failure Surgical obstruction Interstitial nephritis Systemic vaso-dilatation Intra-tubular obstruction ATN Renal & extra-renal fluid loss Post-renal Renal Pre-Renal

59. Uremic Osteodystrophy Hyperphosphatemia Low 1,25 DHCC Hypocalcemia Hyperparathyoidism

63. Treat. Uremic Osteodystrophy Calcitriol or Alfacalcidol Calcium Carbonate Low Phosphate Diet + +

72. Hemodialysis: Dialyzer Arterial blood from Patient Venous blood to patient Incoming Dialysate solution out going dialysate

76. Peritoneal Dialysis: CAPD, IPD PD dialysate solution PD Catheter Hanger Connection set draining bag

85. CRRT: CAVH Arterial Venous UF Replacement Qb=50-100 ml/min Qf= 8-12 ml/min

86. CRRT: CAVHD Arterial Venous Dialysate out Qb=50-100 ml/min Qd=10-20 ml/min Qf= 1-3 ml/min Dialysate In

87. CRRT: CVVH Venous Venous UF Replacement Qb=50-200 ml/min Qf= 10-20 ml/min Pump

88. CRRT: CVVHD Venous Venous Dialysate out Qb=50-200 ml/min Qd=10-30 ml/min Qf= 1-5 ml/min Dialysate In Pump

90. RF : Natural History

91. RF: Differences Always present Usually present Not present Uremic bone disease Usually low May be normal or high Usually low May be normal or high Usually high May be normal Serum K + 1.010 Bland Sediment Sp.gr.: 1.010 Bland sediment Sp.gr.:>1.020 May be active sediment Urine analysis Polyuria or normal Polyuria Anuria, oliguria on non-oliguria Urine output Permanent no function Slow, progressive, irreversible Rapid decline Reversible GFR ESRD CRF ARF