4 General Anesthesia Presentation

General Anesthesia: A more complex mechanism The Meyer-Overton correlation and new research into the mechanism of action of general anesthesia.

Purposes of General Anesthesia: (Inhaled and Intravenous) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Pharmacological Manipulation of the Neuronal Nexus ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Meyer-Overton Correlation ,[object Object],[object Object],[object Object],[object Object],[object Object]

Current Views of Anesthetic Mechanism ,[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object]

Presynaptic Inhibition ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Postsynaptic Inhibition ,[object Object],[object Object]

Inhibitory Pathways ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

GABA-A/B/C ,[object Object],[object Object],[object Object],[object Object],[object Object]

GABA-A Receptor ,[object Object],[object Object],[object Object],[object Object],[object Object]

GABA-A Receptor Voet and Voet 2 nd Edition GABA GABA-A Receptor Cl - Axoplasm

GABA-A Inhibition ,[object Object],[object Object],[object Object],[object Object]

Formation of GABA ,[object Object],[object Object],[object Object]

Degradation of GABA ,[object Object],[object Object],[object Object]

Off Topic  ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Glycine Receptor ,[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],Garrett and Grisham 3 rd Edition

Glycine α -1 Transmembrane Domain Protein Data Bank

Glycine Receptor Gar Garrett and Grisham 3 rd Edition

K + Background (Leak) Channel Excitation ,[object Object],[object Object],[object Object],[object Object],[object Object]

Hypoxic Drive ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Disruption of Ligand Diffusion Chreodes ,[object Object]

Diffusion Chreodes What the %$#* are Chreodes you ask? ,[object Object],[object Object],[object Object],[object Object],[object Object]

Chreodes ,[object Object],[object Object],[object Object],[object Object]

And Finally (I know you’re happy) Chreodes and Anesthesia ,[object Object],[object Object],[object Object]

Partition Coefficients of AA Side Chains and Volatile Anesthetic Drugs ,[object Object],[object Object],[object Object],[object Object]

4 General Anesthesia Presentation

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4 General Anesthesia Presentation