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Taste and Smell
Gustatory / Olfactory pathways


 Daniel Vela-Duarte, MD
 Department of Neurology
 Loyola University Medical Center
 July 2012
Smell.
   It's a warning system to identify
    potentially toxic food or noxious
    chemicals.

   Contributes to various life
    qualities, provides awareness of
    many pleasurable
    sensations, including
    appreciationof certain foods and
    beverages and other pleasures.
The trigeminal system also participates in chemesthesis through
       undifferentiated receptors in the nasal mucosa. These receptors have
        little discriminatory ability but a great sensitivity to all irritant stimuli.



Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
   Olfactory impulses reach
    the cerebral cortex without
    relay through the thalamus.

   Olfaction is unique among
    sensory systems. From the
    prepiriform cortex fibers
    project to the neighboring
    entorhinal cortex and the
    medial dorsal nucleus of
    the thalamus.

   The amygdaloid nuclei
    connect with the
    hypothalamus and septal
    nuclei.
Clinical Manifestations of
Olfactory Lesions
   Quantitative abnormalities:
      loss or reduction of the sense of smell
       (anosmia, hyposmia) or, rarely, increased olfactory
       acuity (hyperosmia)
   Qualitative abnormalities:
      distortions or illusions of smell (dysosmia or
       parosmia)
   Olfactory hallucinations and delusions caused by
    temporal lobe disorders or psychiatric disease
   Higher-order loss of olfactory discrimination (olfactory
    agnosia)
Clinical presentation
   Bilateral anosmia is a common complaint, and
    the patient is usually convinced that the sense of
    taste has been lost as well (ageusia).

   Parosmia may also be a troublesome symptom
    in middle-aged and elderly persons with a
    depressive illness, who may report that every
    article of food has an extremely unpleasant odor
    (cacosmia). Sensations of disagreeable taste
    are often associated cacogeusia).
Differential diagnosis




Adams and Victor's Principles of Neurology. 9th Ed.
Taste
 Older notions of a “tongue map,” which implied
 the existence of specific areas subserving one or
 another taste, are incorrect. Any one taste bud is
    capable of responding to a number of sapid
     substances, but it is always preferentially
          sensitive to one type of stimulus.
Taste and smell." Gustatory and Olfactory Pathways
Taste and smell." Gustatory and Olfactory Pathways

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Taste and smell." Gustatory and Olfactory Pathways

  • 1. Taste and Smell Gustatory / Olfactory pathways Daniel Vela-Duarte, MD Department of Neurology Loyola University Medical Center July 2012
  • 2. Smell.  It's a warning system to identify potentially toxic food or noxious chemicals.  Contributes to various life qualities, provides awareness of many pleasurable sensations, including appreciationof certain foods and beverages and other pleasures.
  • 3.
  • 4. The trigeminal system also participates in chemesthesis through undifferentiated receptors in the nasal mucosa. These receptors have little discriminatory ability but a great sensitivity to all irritant stimuli. Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
  • 5.
  • 6. Olfactory impulses reach the cerebral cortex without relay through the thalamus.  Olfaction is unique among sensory systems. From the prepiriform cortex fibers project to the neighboring entorhinal cortex and the medial dorsal nucleus of the thalamus.  The amygdaloid nuclei connect with the hypothalamus and septal nuclei.
  • 7.
  • 8. Clinical Manifestations of Olfactory Lesions  Quantitative abnormalities:  loss or reduction of the sense of smell (anosmia, hyposmia) or, rarely, increased olfactory acuity (hyperosmia)  Qualitative abnormalities:  distortions or illusions of smell (dysosmia or parosmia)  Olfactory hallucinations and delusions caused by temporal lobe disorders or psychiatric disease  Higher-order loss of olfactory discrimination (olfactory agnosia)
  • 9. Clinical presentation  Bilateral anosmia is a common complaint, and the patient is usually convinced that the sense of taste has been lost as well (ageusia).  Parosmia may also be a troublesome symptom in middle-aged and elderly persons with a depressive illness, who may report that every article of food has an extremely unpleasant odor (cacosmia). Sensations of disagreeable taste are often associated cacogeusia).
  • 10. Differential diagnosis Adams and Victor's Principles of Neurology. 9th Ed.
  • 11. Taste  Older notions of a “tongue map,” which implied the existence of specific areas subserving one or another taste, are incorrect. Any one taste bud is capable of responding to a number of sapid substances, but it is always preferentially sensitive to one type of stimulus.