Typhoid Fever

Typhoid Fever Presented by: Dave Jay S. Manriquez, BSN, RN

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Causative Agent Salmonella Typhi

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Epidemiology ,[object Object],[object Object],[object Object]

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Symptoms ,[object Object],[object Object],[object Object],[object Object],[object Object]

Symptoms ,[object Object],[object Object],[object Object]

Pathognomonic Sign ,[object Object],[object Object]

Complications ,[object Object]

Pathophysiology ,[object Object],survives the acidity of the stomach invades the Peyer’s Patches of the intestinal wall macrophages (Peyer’s Patches)‏ the bacteria is within the macrophages and survives bacteria spreads via the lymphatics while inside the macrophages

Pathophysiology access to Reticuloendothelial system, liver, spleen, gallbladder and bone marrow First week: elevation of the body temperature Second week: abdominal pain, spleen enlargement and rose spots Third week: necrosis of the Peyer’s Patches leads to perforation, bleeding and, if left untreated, death is imminent

Diagnostics ,[object Object],[object Object]

Diagnostics ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Diagnostics ,[object Object],[object Object],[object Object]

Management ,[object Object],[object Object],[object Object],[object Object]

Management ,[object Object],[object Object],[object Object]

Management ,[object Object],[object Object],[object Object],[object Object],[object Object]

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Management ,[object Object],5 years 1 capsule every other day, total of 3 capsules Oral 6 years Ty21 a, live 3 years 0.5 ml Subcutaneous 2 years Vi CPS 3 years 0.5 ml (0.25 ml for children < 10y)‏ x 2 times, 4 weeks apart Subcutaneous 5 years Killed whole-cell vaccine Revaccination Dosage Route Age Vaccine

Management ,[object Object],[object Object]

Historical Background Mary Mallon (September 23, 1869 – November 11, 1938)

Typhoid Fever

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