The R Service Bus (RSB) allows R to be plugged into various software workflows independently of the technologies used. It provides a RESTful and SOAP API to integrate R scripts and Sweave files into machine-to-machine and human workflows. RSB is asynchronous at its core and can handle slow, repetitive, or big data jobs. It is used in production in pharmaceutical, biotechnology, and finance companies. RSB is open source and released as a WAR file and Tomcat bundle to run on Java/Spring platforms.