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Salt Formation To Decrease The Solubility Of A Drug – A Case Study On A Commercially Available Formulation
1. Salt formation to DECREASE the
solubility of a drug – A case study
on a commercially available
formulation
Presented by: Debanjan Das
NOTE: Typically, salt formation is carried out
to enhance solubility. Here, the reverse
process was required to adjust required
bioavailability
2. Reasons to decrease solubility
Controlled release and/or BA
Depot formulations
Ease of processing
Ca, Mg salts of organic acids form soaps which
can tolerate the rigors of manufacturing
operations
Easier to control polymorphism with a salt of less
solubility
3. Model drug studied
Hydroxyzine
Hydroxyzine HCl
Hydroxyzine Pamoate
Ref: Hydroxyzine - A Medical Dictionary, Bibliography, and Annotated Research Guide, Icon
Health Publications; Icon Health Publications, ISBN: 0597844569, March 2004