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Endometrial Carcinoma Bibo Yuan M.D,Ph.D. [email_address] OB/GYN Department of General Hospital, Tianjin Medical Univ.

INTRODUCTION ,[object Object],[object Object],[object Object],[object Object]

INTRODUCTION ,[object Object],[object Object]

INTRODUCTION ,[object Object],[object Object],[object Object]

Etiology ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Long-term estrogen exposure ,[object Object]

Estrogen replacement induces uterine hyperplasia ,[object Object]

Long-term estrogen exposure ,[object Object],[object Object]

Genetic factor in development of endometrial cancer ,[object Object],[object Object],[object Object],[object Object]

Others ,[object Object],[object Object],[object Object],[object Object]

Summary of risk factors ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Histopathologic Classification ,[object Object],[object Object]

Histopathologic Classification ,[object Object],[object Object],[object Object],[object Object],[object Object]

Histopathologic Classification ,[object Object],[object Object],[object Object],[object Object]

Endometrial hyperplasia, simple ,[object Object],[object Object],[object Object],The endometrial glands in this lesion are irregularly distributed but widely separated by stroma, which is also hyperplastic. The glands are mostly round or tubular, with only a few angularities encountered.

Endometrial hyperplasia, complex

Atypical hyperplasia (simple) The glandular epithelium here is extremely atypical, but residual endometrial stroma separates all glands in this field. Because of the severity of the atypia, a specimen such as this should be examined thoroughly to rule out the concomitant presence of carcinoma.

Endometrial hyperplasia with atypia ,[object Object], Atypical endometrial hyperplasia.

Hyperplasia ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Histopathologic Classification ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Histopathologic Classification ,[object Object]

Endometrioid carcinoma Endometrioid carcinoma at low (A) and high (B) power shows gland formation, and cells with a low nuclear to cytoplasmic ratio. Higher grade endometrioid carcinoma would show a greater proportion of solid growth.

Adenocarcinoma of endometrium ,[object Object]

Serous carcinoma ,[object Object],Serous carcinoma at high power (A) showing a complex branching pattern forming irregular spaces into which tumor cells exfoliate. Tumor cells have high nuclear to cytoplasmic ratio, and the nuclei show size and shape variation (pleomorphism). Serous carcinomas typically overexpress an abnormal form of the p53 gene product as demonstrated by immunohistochemistry (B).

Possible routes of spread ,[object Object],[object Object],[object Object],[object Object]

Surgical staging ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Surgical staging ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Clinical ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

CLINICAL PRESENTATION ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Endometrial Cancer Diagnosis & Tests ,[object Object],[object Object],[object Object],[object Object]

DIAGNOSIS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Differential Diagnosis ,[object Object],[object Object]

Complications ,[object Object],[object Object]

Treatment ,[object Object],[object Object]

Surgical Care ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Surgical Care ,[object Object],[object Object],[object Object]

Antitumor Chemotherapy ,[object Object],[object Object]

Radiation Therapy ,[object Object],[object Object],[object Object]

Hormone therapy ,[object Object],[object Object],[object Object]

Endometrial Cancer Prognosis (Expectations) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Endometrial Cancer Prevention ,[object Object],[object Object],[object Object],[object Object],[object Object]

Summary ,[object Object],[object Object],[object Object],[object Object],[object Object]

Question ,[object Object],[object Object],[object Object]

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