Padrino is a web framework based on Sinatra that provides additional helper methods and a Rails-like directory structure. Sequel is used for database access and provides an Arel-style query interface. The presentation demonstrates building a basic to-do list application from scratch using Padrino and Sequel, and then enhancing it with Padrino's admin panel generator. It also reviews code for archiving projects to offline storage with MySQL full-text search of archive contents and Basic Auth security. More information can be found on the Padrino, Sinatra, and Sequel websites.