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Hla typi ng pg seminar final 0604

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deepak deshkar
deepak deshkar

HLA - Human Leukocyte Antigen - For organ transplant

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Human Leukocyte Antigen (HLA) Typing Dr.D.W.Deshkar
HLA = Human Leucocyte Antigen system ,[object Object],[object Object],[object Object]
HLA = Human Leucocyte Antigen system ,[object Object],[object Object],[object Object],[object Object]
HLA = Human Leucocyte Antigen system ,[object Object],[object Object],[object Object]
HLA = Human Leucocyte Antigen system ,[object Object],[object Object],[object Object],[object Object],[object Object]
Histocompatibility complex ,[object Object],[object Object]
HLA complex ,[object Object],[object Object],[object Object],[object Object],[object Object]
HLA complex ,[object Object],[object Object]
HLA Molecules
MHC- I & MHC-II
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Microglobulin (12 kDa) associates non-covalently with  3 Microglobulin and  3 are part of immunoglobulin superfamily Microglobulin is the only member of the superfamily that does not have a component linking it to a membrane
Isotypes of MHC molecules
What are the genetic mechanisms? ,[object Object],[object Object],[object Object]
What are the genetic mechanisms? ,[object Object],[object Object],[object Object],[object Object]
What does the “syntenic” organization of a haplotype look like? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
What is polygenecity? ,[object Object],[object Object]
There are no rearrangements! ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
MHC Antigen Nomenclature ,[object Object],[object Object],[object Object]
[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object]
HLA - Typing ,[object Object],[object Object],[object Object]
[object Object],[object Object],SEROLOGY
[object Object],[object Object],[object Object],SEROLOGY
Microlymphocytotoxic test ,[object Object],[object Object]
Microlymphocytotoxic test Contd …. ,[object Object],[object Object],[object Object]
Microlymphocytotoxic test Contd ….
Microlymphocytotoxic test Contd …. ,[object Object],[object Object]
Microlymphocytotoxic test Contd …. ,[object Object],[object Object]
Microlymphocytotoxic test Contd …. ,[object Object],[object Object],[object Object],[object Object]
Microlymphocytotoxic test Contd …. ,[object Object],[object Object],[object Object]
 
[object Object]
Mixed Lymphocyte Reaction Allele A Recipient cell sharing Class II MHC of donors No reaction Irradiation Allele A Donor cells Allele B Recipient cells lacking Class II MHC of donor Activation & proliferation of recipient cells [ 3 H] thymidine Incorporation of radioactivity into Cell Nuclear DNA
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Mixed Lymphocyte Reaction
Pros and cons ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Cellular typing ,[object Object],[object Object],[object Object],[object Object]
Molecular typing ,[object Object],[object Object],[object Object],[object Object]
Molecular typing Contd ……. ,[object Object],[object Object],[object Object]
Molecular typing Contd ……. ,[object Object],[object Object],[object Object]
Molecular typing Contd ……. ,[object Object],[object Object],[object Object]
Molecular typing Contd ……. ,[object Object],[object Object],[object Object],[object Object],[object Object]
Molecular typing Contd ……. ,[object Object],[object Object],[object Object],[object Object]
Molecular typing Contd ……. ,[object Object],[object Object],[object Object],[object Object],[object Object]
Molecular typing Contd ……. ,[object Object],[object Object]
Molecular typing Contd ……. ,[object Object],[object Object],[object Object],[object Object],[object Object]
Pros and cons ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
MHC-Linked Diseases ,[object Object],[object Object]
MHC-Linked Immunodeficiencies ,[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
 
THANKS That’s all for Now! Stay tuned for more exciting topics on immunology!

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Hla typi ng pg seminar final 0604

  • 1. Human Leukocyte Antigen (HLA) Typing Dr.D.W.Deshkar
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  • 10. MHC- I & MHC-II
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  • 12. Isotypes of MHC molecules
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  • 33. Mixed Lymphocyte Reaction Allele A Recipient cell sharing Class II MHC of donors No reaction Irradiation Allele A Donor cells Allele B Recipient cells lacking Class II MHC of donor Activation & proliferation of recipient cells [ 3 H] thymidine Incorporation of radioactivity into Cell Nuclear DNA
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  • 52. THANKS That’s all for Now! Stay tuned for more exciting topics on immunology!