Pancreatitis sample questions based on neet pg , usmle, plab and fmge pattern...
Sample question paper for neet pg, usmle, plab and fmge (mci screeing exam) on thymoma
1. Q:1 Which of the following condition is associated with thymoma?
A: Myasthenia gravis
B: Rheumatoid arthritis
C: Scleroderma
D: Renal failure
Correct Ans:A
Explanation
In patients with myasthenia gravis, thymus is abnormal in 75% cases, it is hyperplastic in 65%
and thymoma is present in 10% of cases.
Reference:
Harrison's Principles Of Internal Medicine 18th edition chapter
386.
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Q:2 Which is the most common cause of SVC syndrome?
A: Lung cancer
B: Trauma
C: Thymoma
D: Fibrosis of SVC
Correct Ans:A
Explanation
Lung cancer is the most common cause of SVC syndrome. Non
Hodgkins lymphoma is the second most common cause. Primary
mediastinal malignancies such as thymoma and germ cell tumors
account for less than 2% cases. Breast cancer is the most
common metastatic disease causing SVC syndrome.
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Q:3 Which of the following is not associated with thymoma:
A: Red cell aplasia
2. B: Myasthenia gravis
C: Hypergammaglobulinemia
D: Compression of the superior mediastinum
Correct Ans:C
Explanation
Thymoma associated autoimmune diseases are:
? Myasthenia gravis
? Phemphigus
? Systemic lupus erythematosus
? Pure red cell aplasia
? Hypogammaglobulinemia
Ref: Illustrated Dictionary of Immunology By M.P. Arora, Pages 257258 ; Cancer and
Autoimmunity By Yehuda Shoenfeld, M. Eric Gershwin, Page 249 ; Harrison’s Principle
of Internal Medicine, 16th Edition, Page 1946
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Q:4
A 60 year old male presented to the emergency with breathlessness, facial
swelling and dilated veins on the chest wall. Which of the following is the most
common cause?
A: Thymoma
B: Lung cancer
C: Hodgkin's lymphoma
D: Superior vena caval obstruction
Correct Ans:D
Explanation
Patient in the question is showing signs and symptoms typical of superior vena caval
obstruction which result in severe reduction in venous return from the head, neck, and
upper extremities.
Most common causes includes lung cancer, lymphoma, and metastatic tumors. 85% of
cases occur due to small and squamous cell carcinoma of the lung. In young adults,
malignant lymphoma is a leading cause. Other causes include benign tumors, aortic
aneurysm, thyromegaly, thrombosis, and fibrosing mediastinitis from prior irradiation,
histoplasmosis, or Behçet's syndrome.
Ref: Harrsions Internal Medicine, 18th Edition, Chapter 276
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Q:5 All of the following may be associated with Thymoma, except:
A: SIADH
3. B: Cushing's syndrome
C: Hypogammaglobulinemia
D: None of the above
Correct Ans:D
Explanation
Thymoma is rare tumor in children and account for less than 1% of all the anterior
mediastinal tumors. Thymomas are associated with a variety of paraneoplastic
conditions.
Ref: Harrison’s Principles of internal medicine 18th edition/chapter 340, table 340
2; Pediatric Thoracic SurgeryBy Dakshesh Parikh, page 581; Manual of Clinical
Oncology By Dennis Albert Casciato, page 409.
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Q:6 To diagnose thymoma in a case of mediastinal mass is:
A: Thoracotomy and biopsy
B: FNAC
C: Chest CT scan
D: Somatostatin receptor imaging
Correct Ans:A
Explanation
Once a mediastinal mass is detected,
Next step:
1. Initial mediastinoscopy or limited thoracotomy to get sufficient tissue to make an
accurate diagnosis.
2. Fineneedle aspiration is poor at distinguishing between lymphomas and thymomas
3. Subsequent staging of thymoma can be done with chest CT scans
4. MRI has a defined role in the staging of posterior mediastinal tumors
5. Somatostatin receptor imaging with indiumlabeled somatostatin analogues also
used for staging
Ref: Harrison, E18, chapter e20.
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Q:7 The staging system for thymoma was developed by:
A: Masaoka
B: Yokohama
C: Todani
D: Kluivert
6. A: Polymyositis
B: Sjogrens syndrome
C: Ulcerative colitis
D: Crohns disease
Correct Ans:D
Explanation
Patients with myasthenia gravis10–15% have thymoma.
Thymoma may be associated with polymyositis, systemic lupus erythematosus,
thyroiditis, Sjögren's syndrome, ulcerative colitis, pernicious anemia, Addison's disease,
scleroderma, and panhypopituitarism.
Ref: Harrison, E18, Chapter e20
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Q:12 The correct statement regarding thymectomy in myasthenia gravis patients is:
A: Should be done in all cases
B: Should be done in cases with ocular involvement only
C: Not required if controlled by medical management
D: Should be done only in cases that are associated with thymoma
Correct Ans:A
Explanation
Thymectomy should be carried out in every patient associated with generalized
myasthenia gravis between the age groups from puberty to ~55 yrs of age and should
be considered in every patient <60 yrs of age. Done even in those cases, controlled by
medical treatment.
Ref: Harrison’s Principle of Internal Medicine, 16th Edition, Page 2522
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Q:13
During exploration, a patient is found to have a tumor in the thymus that is
invading the pericardium and surrounding the left and right phrenic nerves.
The pathologist says that appears on frozen section to be a benign thymoma.
The surgeon now should
A: Repeat frozen section
B: Attempt as complete a resection as possible
C: Close the chest and plan irradiation therapy