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1
The Digestive System
2
Digestion
• Processing of food
• Types
– Mechanical (physical)
• Chew
• Tear
• Grind
• Mash
• Mix
– Chemical
• Catabolic reactions
• Enzymatic hydrolysis
– Carbohydrate
– Protein
– Lipid
3
Digestion
• Phases
– Ingestion
– Movement
– Digestion
– Absorption
– Further digestion
4
Digestive System Organization
• Gastrointestinal (Gl) tract (Alimentary canal)
– Tube within a tube
– Direct link/path between organs
– Structures
• Mouth
• Oral Cavity
• Pharynx
• Esophagus
• Stomach
• Duedenum
• Jejenum
• kIleum
• Cecum
• Ascending colon
• Transverse colon
5
Digestive System Organization
• Descending colon
• Sigmoid colon
• Rectum
• Anus
• Accessory structures
– Not in tube path
– Organs
• Teeth
• Tongue
• Salivary glands
• Liver
• Gall bladder
• Pancreas
6
Anatomy of the Mouth and
Throat
7
Human Deciduous and
Permanent Teeth
8
Dorsal Surface of the Tongue
9
The Major Salivary Glands
10
Deglutition (swallowing)
• Sequence
– Voluntary stage
• Push food to back of
mouth
– Pharyngeal stage
• Raise
– Soft palate
– Larynx + hyoid
– Tongue to soft palate
– Esophageal stage
• Contract pharyngeal
muscles
• Open esophagus
• Start peristalsis
11
Deglutition (swallowing)
• Control
– Nerves
• Glossopharyngeal
• Vagus
• Accessory
– Brain stem
• Deglutition center
– Medulla oblongata
– Pons
– Disorders
• Dysphagia
• Aphagia
12
Esophagus
• Usually collapsed (closed)
• 3 constrictions
– Aortic arch
– Left primary bronchus
– Diaphragm
• Surrounded by
– SNS plexus
– Blood vessels
• Functions
– Secrete mucous
– Transport food
13
Peristalsis and Segmentation
14
Esophagus
• Sphincters
– Upper
– Lower
• Abnormalities
– Achalasia
– Atresia
– Hernia
– Barret’s esophagus
– Esophageal varices
15
Stomach
• Usually “J” shaped
• Left side, anterior to the spleen
• Mucous membrane
– G cells – make gastrin
– Goblet cells – make mucous
– Gastric pit – Oxyntic gland – Parietal cells – Make
HCl
– Chief cells – Zymogenic cells
• Pepsin
• Gastric lipase
16
Anatomy of the Stomach
17
Stomach
• 3 muscle layers
– Oblique
– Circular
– Longitudinal
• Regions
– Cardiac sphincter
– Fundus
– Antrum (pylorus)
– Pyloric sphincter
• Vascular
• Inner surface thrown into
folds – Rugae
• Contains enzymes that work
best at pH 1-2
18
Stomach
• Functions
– Mix food
– Reservoir
– Start digestion of
• Protein
• Nucleic acids
• Fats
– Activates some enzymes
– Destroy some bacteria
– Makes intrinsic factor – B
12 absorption
– Destroys some bacteria
– Absorbs
• Alcohol
• Water
• Lipophilic acid
• B 12
19
Small Intestine
• Extends from pyloric
sphincter  ileocecal
valve
• Regions
– Duodenum
– Jejenum
– Ileum
• Movements
– Segmentation
– Peristalsis
20
Small Intestine
• Histology
– Intestinal glands – Intestinal enzymes
– Duodenal glands – Alkaline mucous
– Paneth cells – Lysozyme
– Microvilli
– Lacteals
– Plica circularis
– Smooth muscle
– Lymphatic tissue – GALT
– Vascular
21
Small Intestine
• Absorbs
– 80% ingested water
– Electrolytes
– Vitamins
– Minerals
– Carbonates
• Active/facilitated
transport
• Monosaccharides
– Proteins
• Di-/tripeptides
• Amino acids
– Lipids
• Monoglycerides
• Fatty acids
• Micelles
• Chylomicrons
22
Structure of the Villi in the
Small Intestine
23
Small Intestine
• Secretes digestive
enzymes
– Peptidases
• Amino-
• Di-
• Tri-
– Sucrases
– Maltase
– Lactase
– Saccharidases
• Di-
• Tri-
– Lipase
– Nucleases
24
Small Intestine
• Control
• Requires pancreatic
enzymes & bile to
complete digestion
25
Large Intestine
• Extends from ileocecal valve to anus
• Regions
– Cecum – Appendix
– Colon
• Ascending
• Transverse
• Descending
– Rectum
– Anal canal
26
Anatomy of the Large Intestine
27
Large Intestine
• Histology
– No villi
– No permanent circular folds
– Smooth muscle
• Taeniae coli
• Haustra
– Epiploic appendages
– Otherwise like rest of Gl tract
28
Large Intestine
• Functions
– Mechanical digestion
• Haustral churning
• Peristalsis
• Reflexes
– Gastroileal
– Gastrocolic
– Chemical digestion –
Bacterial digestion
• Ferment carbohydrates
• Protein/amino acid
breakdown
– Absorbs
•More water
•Vitamins
– B
– K
– Concentrate/eliminate
wastes
29
Feces Formation and Defecation
• Chyme dehydrated to
form feces
• Feces composition
– Water
– Inorganic salts
– Epithelial cells
– Bacteria
– Byproducts of digestion
• Defecation
– Peristalsis pushes feces
into rectum
– Rectal walls stretch
• Control
– Parasympathetic
– Voluntary
30
Liver
• Location
– R. Hypochondrium
– Epigastric region
• 4 Lobes
– Left
– Quadrate
– Caudate
– Right
• Each lobe has lobules – Contains hepatocytes –
Surround sinusoids – Feed into central vein
31
Liver
• Functions
– Makes bile
• Detergent – emulsifies
fats
• Release promoted by:
– Vagus n.
– CCK
– Secretin
• Contains
– Water
– Bile salts
– Bile pigments
– Electrolytes
– Cholesterol
– Lecithin
32
Liver
– Detoxifies/removes
• Drugs
• Alcohol
– Stores
• Gycolgen
• Vitamins (A, D, E, K)
• Fe and other minerals
• Cholesterol
– Activates vitamin D
– Fetal RBC production
– Phagocytosis
– Metabolizes absorbed food
molecules
• Carbohydrates
• Proteins
• Lipids
33
Liver
• Dual blood supply
– Hepatic portal vein
• Direct input from small
intestine
– Hepatic artery/vein
• Direct links to heart
34
The Duodenum and Related
Organs
35
The Organs and Positions in the
Abdominal Cavity
36
Structures of the Alimentary
Canal

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Digestivesystem

  • 2. 2 Digestion • Processing of food • Types – Mechanical (physical) • Chew • Tear • Grind • Mash • Mix – Chemical • Catabolic reactions • Enzymatic hydrolysis – Carbohydrate – Protein – Lipid
  • 3. 3 Digestion • Phases – Ingestion – Movement – Digestion – Absorption – Further digestion
  • 4. 4 Digestive System Organization • Gastrointestinal (Gl) tract (Alimentary canal) – Tube within a tube – Direct link/path between organs – Structures • Mouth • Oral Cavity • Pharynx • Esophagus • Stomach • Duedenum • Jejenum • kIleum • Cecum • Ascending colon • Transverse colon
  • 5. 5 Digestive System Organization • Descending colon • Sigmoid colon • Rectum • Anus • Accessory structures – Not in tube path – Organs • Teeth • Tongue • Salivary glands • Liver • Gall bladder • Pancreas
  • 6. 6 Anatomy of the Mouth and Throat
  • 8. 8 Dorsal Surface of the Tongue
  • 10. 10 Deglutition (swallowing) • Sequence – Voluntary stage • Push food to back of mouth – Pharyngeal stage • Raise – Soft palate – Larynx + hyoid – Tongue to soft palate – Esophageal stage • Contract pharyngeal muscles • Open esophagus • Start peristalsis
  • 11. 11 Deglutition (swallowing) • Control – Nerves • Glossopharyngeal • Vagus • Accessory – Brain stem • Deglutition center – Medulla oblongata – Pons – Disorders • Dysphagia • Aphagia
  • 12. 12 Esophagus • Usually collapsed (closed) • 3 constrictions – Aortic arch – Left primary bronchus – Diaphragm • Surrounded by – SNS plexus – Blood vessels • Functions – Secrete mucous – Transport food
  • 14. 14 Esophagus • Sphincters – Upper – Lower • Abnormalities – Achalasia – Atresia – Hernia – Barret’s esophagus – Esophageal varices
  • 15. 15 Stomach • Usually “J” shaped • Left side, anterior to the spleen • Mucous membrane – G cells – make gastrin – Goblet cells – make mucous – Gastric pit – Oxyntic gland – Parietal cells – Make HCl – Chief cells – Zymogenic cells • Pepsin • Gastric lipase
  • 16. 16 Anatomy of the Stomach
  • 17. 17 Stomach • 3 muscle layers – Oblique – Circular – Longitudinal • Regions – Cardiac sphincter – Fundus – Antrum (pylorus) – Pyloric sphincter • Vascular • Inner surface thrown into folds – Rugae • Contains enzymes that work best at pH 1-2
  • 18. 18 Stomach • Functions – Mix food – Reservoir – Start digestion of • Protein • Nucleic acids • Fats – Activates some enzymes – Destroy some bacteria – Makes intrinsic factor – B 12 absorption – Destroys some bacteria – Absorbs • Alcohol • Water • Lipophilic acid • B 12
  • 19. 19 Small Intestine • Extends from pyloric sphincter  ileocecal valve • Regions – Duodenum – Jejenum – Ileum • Movements – Segmentation – Peristalsis
  • 20. 20 Small Intestine • Histology – Intestinal glands – Intestinal enzymes – Duodenal glands – Alkaline mucous – Paneth cells – Lysozyme – Microvilli – Lacteals – Plica circularis – Smooth muscle – Lymphatic tissue – GALT – Vascular
  • 21. 21 Small Intestine • Absorbs – 80% ingested water – Electrolytes – Vitamins – Minerals – Carbonates • Active/facilitated transport • Monosaccharides – Proteins • Di-/tripeptides • Amino acids – Lipids • Monoglycerides • Fatty acids • Micelles • Chylomicrons
  • 22. 22 Structure of the Villi in the Small Intestine
  • 23. 23 Small Intestine • Secretes digestive enzymes – Peptidases • Amino- • Di- • Tri- – Sucrases – Maltase – Lactase – Saccharidases • Di- • Tri- – Lipase – Nucleases
  • 24. 24 Small Intestine • Control • Requires pancreatic enzymes & bile to complete digestion
  • 25. 25 Large Intestine • Extends from ileocecal valve to anus • Regions – Cecum – Appendix – Colon • Ascending • Transverse • Descending – Rectum – Anal canal
  • 26. 26 Anatomy of the Large Intestine
  • 27. 27 Large Intestine • Histology – No villi – No permanent circular folds – Smooth muscle • Taeniae coli • Haustra – Epiploic appendages – Otherwise like rest of Gl tract
  • 28. 28 Large Intestine • Functions – Mechanical digestion • Haustral churning • Peristalsis • Reflexes – Gastroileal – Gastrocolic – Chemical digestion – Bacterial digestion • Ferment carbohydrates • Protein/amino acid breakdown – Absorbs •More water •Vitamins – B – K – Concentrate/eliminate wastes
  • 29. 29 Feces Formation and Defecation • Chyme dehydrated to form feces • Feces composition – Water – Inorganic salts – Epithelial cells – Bacteria – Byproducts of digestion • Defecation – Peristalsis pushes feces into rectum – Rectal walls stretch • Control – Parasympathetic – Voluntary
  • 30. 30 Liver • Location – R. Hypochondrium – Epigastric region • 4 Lobes – Left – Quadrate – Caudate – Right • Each lobe has lobules – Contains hepatocytes – Surround sinusoids – Feed into central vein
  • 31. 31 Liver • Functions – Makes bile • Detergent – emulsifies fats • Release promoted by: – Vagus n. – CCK – Secretin • Contains – Water – Bile salts – Bile pigments – Electrolytes – Cholesterol – Lecithin
  • 32. 32 Liver – Detoxifies/removes • Drugs • Alcohol – Stores • Gycolgen • Vitamins (A, D, E, K) • Fe and other minerals • Cholesterol – Activates vitamin D – Fetal RBC production – Phagocytosis – Metabolizes absorbed food molecules • Carbohydrates • Proteins • Lipids
  • 33. 33 Liver • Dual blood supply – Hepatic portal vein • Direct input from small intestine – Hepatic artery/vein • Direct links to heart
  • 34. 34 The Duodenum and Related Organs
  • 35. 35 The Organs and Positions in the Abdominal Cavity
  • 36. 36 Structures of the Alimentary Canal