HPV is the cause of cervical cancer. There is a long lag between infection and development of cancer. There are two major opportunities to prevent this entirely preventable cancer.
27. HPV Genome
• E1-E7 = “Early” genes
(nonstructural)
• L1, L2 = Capsid genes
• URR = upstream regulatory
region
• E6 & E7 proteins play
major role in immortality &
malignant transformation of
infected cells
• E5 has role, but not
required to maintain cancer
phenotype
Munoz et al. 2006.
30. HPV-containing double
stranded DNA
‘Empty’ non-infectious
virus-like particle (VLP)
mimics the virus
Virus-like particles (VLPs) as HPV vaccine
antigens mimic the virus structure
Stanley M, et al. Vaccine 2006; 24(suppl 3):S3/106–113.
31. Vaccines
• Gardasil (2006) :
– Contains HPV 16, 18, 6, 11
• Cerverix (2009): Contains HPV 16, 18
– Females 10 through 25
– For:
• Ca Cx
• CIN
• Adenocarcinoma in situ
– Gardasil for males too and for Ca Anus, warts
etc
32.
33. Two Opportunities to prevent Cx Ca
Normal
cervix
HPV
infection
Cervical
Intraepitheili
al neoplasia
CIN
Cervical
Cancer
HPV
vaccine
HPV & Cx
screen & t/t
10- 18 18 – 25 > 30
50. Cervical Cancer is entirely preventable
1.Vaccination before exposure
2.Screening after 30 yrs (every 5 yrs)
Though STI,
it does not imply un-faithfullness
Cancer free RAK / UAE by 2020
Become a national achievable goal
Insurance be instructed to approve
Vaccination & Co-testing
51. Please Join, Support & Promote
Scientists have the tools, but cannot do it alone
Thank you for your attention
Notes de l'éditeur
Munoz et al. Vaccine 24S3 (2006) S3/1-S3/10
Cervarix®, the candidate cervical cancer vaccine is composed of DNA-free virus-like particles of the capsid protein L1.1 Virus-like particles of L1 alone have been shown to be similar in both structure and immunogenicity to authentic papilloma virions and to be strong inducers of neutralizing antibody responses.1–3
References
1. Giannini S, et al. Vaccine 2006; 24:5937–5949.
2. Christensen N, et al. J Gen Virol 1994; 75:2271–2276.
3. Rose R, et al. J Gen Virol 1994; 75:2075–2079.