8 Biology Of Sexual Identity

Biology of Sexual Identity Harry Benjamin's Syndrome (HBS) Estimated incidence of HBS is 1 in 100.000 live births

The Transsexual Brain ,[object Object],[object Object],[object Object],[object Object]

MtF Brains ,[object Object],[object Object],[object Object]

Bed Nucleus of the Stria Terminalis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Localization of the BST ,[object Object],[object Object],[object Object],[object Object],Zhou, J.N. Hofman, M.A. Gooren, L.J. and Swaab, D.F.. A Sex Difference in the Human Brain and its Relation to Transsexuality. NATURE, 378: 68-70 (1995)

Bed Nucleus of the Stria Terminalis Figure 2 : Representative sections of the BSTc innervated by vasoactive intestinal polypeptide (VIP). A: heterosexual man; B: heterosexual woman; C: homosexual man; D: male-to-female transsexual. Bar=0.5 mm. LV: lateral ventricle. Note there are two parts of the BST in A and B: small sized medial subdivision (BSTm), and large oval-sized central subdivision (BSTc) Zhou, J.N. Hofman, M.A. Gooren, L.J. and Swaab, D.F.. A Sex Difference in the Human Brain and its Relation to Transsexuality. NATURE, 378: 68-70 (1995)

Bed Nucleus of the Stria Terminalis ,[object Object],[object Object],[object Object],[object Object],[object Object]

BSTc Volume Is Not Affected by Varying Sex Hormone Levels in Adulthood ,[object Object],[object Object],[object Object]

Small-Sized BSTc in MtF Not Due to Estrogen Treatment ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Large-sized BSTc in MtF Not Due to Lack of Androgens ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Results & Conclusions ,[object Object],[object Object],[object Object],[object Object],[object Object]

2 nd Study: Methodology to Study BSTc ,[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Somatostatin Results Parallel VIP Results

What’s Missing in the Sexual Identity Picture? ,[object Object],[object Object],[object Object]

FtM Has Same Neuron Number in BSTc as Typical Male ,[object Object],[object Object],[object Object],[object Object],[object Object]

BSTc Neuron Number Is Not Related to Sexual Orientation ,[object Object],[object Object],[object Object],Kruijver, Frank P. M., Zhou, Jiang-Ning, Pool, Chris W. Hofman, Michel A.,. Gooren, Louis J. G And Swaab, Dick F. Male-To-Female Transsexuals Have Female Neuron Numbers In A Limbic Nucleus. J CLIN ENDOCRINOL METAB, 85: 2034-2041 (2000)

Genetics of MtF Transsexuality ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Genetics of FtM Transsexuality ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Different Routes to Sexual Identity ,[object Object],[object Object],[object Object]

8 Biology Of Sexual Identity

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8 Biology Of Sexual Identity