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05/01/10
Osteoporosis Definition ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],05/01/10
Osteoporosis ,[object Object],[object Object],[object Object],[object Object],05/01/10
Diagnosis:  x-ray -No ,[object Object],[object Object],[object Object],05/01/10
Bone Mineral Density ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],GOLD STANDARD 05/01/10
WHO  Classification Normal  : BMD within 1 to -1 SD Osteopenia  :BMD -1 - 2.5 SD Osteoporosis :BMD -2.5 SD or more 05/01/10
MANAGEMENT ,[object Object],[object Object],[object Object],[object Object],[object Object],05/01/10
CALCIUM AND VITAMIN  D ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],05/01/10
Updated National Osteoporosis Foundation (NOF) guidelines 2008 ,[object Object],[object Object],[object Object],[object Object],[object Object],05/01/10
Drugs available and on horizons ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],05/01/10
ESTROGEN ,[object Object],[object Object],[object Object],[object Object],[object Object],05/01/10
HT  ,[object Object],[object Object],[object Object],[object Object],05/01/10
SERMS- RALOXIFENE (EVISTA®) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],05/01/10
SERM- Bazedoxifene  ,[object Object],[object Object],[object Object],[object Object],05/01/10
Selective Estrogen Receptor-ß Agonist, MF-101 ( 22 chinese herbal medicines) ,[object Object],[object Object],[object Object],[object Object],[object Object],05/01/10
TSEC & SERMS ,[object Object],[object Object],05/01/10
05/01/10
BISPHOSPHONATES ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],05/01/10
Alendronate (Bishphonate) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],05/01/10
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],05/01/10
RISEDRONATE (ACTONEL®) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],05/01/10
RISEDRONATE   ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],05/01/10
CALCITONIN ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],05/01/10
CALCITONIN ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],05/01/10
CALCITONIN ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],05/01/10
CALCITONIN ,[object Object],[object Object],[object Object],[object Object],[object Object],05/01/10
ANABOLIC AGENTS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],05/01/10
PTH ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],05/01/10
PTH   (Forteo) Neer et al. (2001) NEJM 344(19), 1434-1441 ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],05/01/10
PTH (Forteo) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],05/01/10
New Drug Denosumab ,[object Object],05/01/10
Dose  of Denosumab ,[object Object],05/01/10
ORTHOSIS ,[object Object],[object Object],[object Object],[object Object],05/01/10 dr.maninder AICOG2009 Improved back extensor strength  correlate with decreased kyphosis and diminished vertebral fracture risk. Hip protectors don’t reduce incidence of hip fractures Van Schoor NM, Smit JH, Twisk JWR, et al. Prevention of hip fractures by external hip protectors: a randomized controlled trial.  JAMA . 2003;289(15):1957–1962
FALL PREVENTION  ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],05/01/10 dr.maninder AICOG2009
To Summarise”Drugs for prevention&treatment”  ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],05/01/10 dr.maninder AICOG2009
Lower Higher -2.5 BMD (T-score) Bisphosphonates Osteoporosis Therapy Algorithm Postmenopausal Women 05/01/10 Raloxifene PTH Calcitonin HRT HRT During Hot  Flashes Post Vasomotor Symptoms Pre fracture Post Fracture Risk  of Fracture AGE At Risk/Osteopenia Osteoporosis Severe Osteoporosis STAGE
OSTEOPOROSIS  HIP FRACTURES 05/01/10
OSTEOPOROSIS  HIP FRACTURES  ,[object Object],[object Object],[object Object],05/01/10
OSTEOPOROSIS  SPINE FRACTURES ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],05/01/10
05/01/10
05/01/10
Final Word  ,[object Object],[object Object],05/01/10
Final Message  ,[object Object],[object Object],[object Object],05/01/10
ACKNOWLEDGEMENT ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Dr.Maninder Ahuja  Chairperson Geriatric Gynecology Committee FOGSI 05/01/10

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Management of osteoporosis final

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  • 6. WHO Classification Normal : BMD within 1 to -1 SD Osteopenia :BMD -1 - 2.5 SD Osteoporosis :BMD -2.5 SD or more 05/01/10
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  • 36. Lower Higher -2.5 BMD (T-score) Bisphosphonates Osteoporosis Therapy Algorithm Postmenopausal Women 05/01/10 Raloxifene PTH Calcitonin HRT HRT During Hot Flashes Post Vasomotor Symptoms Pre fracture Post Fracture Risk of Fracture AGE At Risk/Osteopenia Osteoporosis Severe Osteoporosis STAGE
  • 37. OSTEOPOROSIS HIP FRACTURES 05/01/10
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Notes de l'éditeur

  1. that is not yet clinically available but has been studied in large prospective randomized clinical trials. TSECs appear to offer relief of vasomotor symptoms without inducing endometrial hyperplasia and without the breast stimulation seen with estrogens and/or progestogens. This promising new therapy may be available to the patient presented above at some point in the future.