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Backache Imaging Presentation

        Hieder A`ala
            601
       MUST University
Wasted time?

   Radiology departments do lots of imaging
    for low back pain.
   X-rays, CT, MRI etc.
   How much makes a difference?
   Studies show advanced imaging in acute
    back pain and sciatica doesn’t change
    outcomes, but improves diagnostic
    confidence.
Causes of back pain and
sciatica
   Paraspinal muscles            Spondylosis
    and ligaments                     Spinal stenosis
   Synovial joints:                  Foraminal stenosis
       Facet and sacroiliac      Bone disease
        joints                        Tumor
   Disc disease                      Fracture
       Tear of annulus           Infection
        fibrosis                      Epidural abscess
       Specific nerve root           discitis
        impingements
Acute Back Pain
   2nd most common complaint to primary
    care physician
   >75% of adults will suffer it at some
    time.
   90% will resolve without intervention (or
    imaging), most without a specific dx.
   Among patients with sciatica, only
    <10% will need surgery.
   Whom to image?
Back pain imaging — false
positives
   Most adults over 40 will have
    degenerative changes on x-rays
   MRI shows disc pathology in the majority
    of adults
   Many asymptomatic people have disc
    bulges and protrusions.
   So, imaging is likely to result in an
    abnormal report.
   But correlation between radiographic
    findings and clinical symptoms is poor.
   When to image?
When to image in patients with
        acute back pain?
   Most authorities suggest conservative
    treatment for 4-6 weeks unless there are
    “red flags”:
       Look for historical and physical findings that
        raise clinical question of infection, tumor, or
        serious neurological impairment
       Even positive findings of degenerative
        disease like disc extrusions and spinal
        stenosis are not urgent and will be treated
        conservatively at first.
“Red flags” for early imaging
   Severe progressive neurological deficit
   Fracture?
       Major trauma or minor trauma in osteoporotic pt.
   Tumor?
       History of cancer, weight loss
       Pain worse at night or when supine
   Infection?
       Recent bacterial infection, immune supression,
        fever, IVDA
Imaging options
   Radiography
   CT
       Better for fine bone detail, arthritis
       As good as MRI for acute disc disease
       Myelography as adjunct
   MRI
       Very good for disc, paraspinal pathology, stenosis
       Infection
       Marrow disorders
       Contrast for infection, post-op, tumor
   Bone scan
       Not for primary imaging in most cases
   Discography
Radiography

   AP and lateral films
   Oblique films
   Flexion / extension films
Radiography
   Diagnoses that can be made on AP and
    lateral:
       Spondylolisthesis
       Compression fracture
       SI joint disease
       Disc degeneration
       Facet arthritis
       Tumor
       Infection in disc space
Discitis
Radiography
   Diagnosis
    best made on
    oblique films:
       Spondylolysis
                          Facet joints
       Facet arthritis
       Foraminal
        stenosis
        (cervical
        spine)
Radiography
    Diagnosis made with flexion / extension
     films:
        instability
Spondylolysis
   Stress fracture through pars interarticularis
   If bilateral, can cause spondylolisthesis
    Sagittal reformatted CT                  spondylolysis




                                  spondylolisthesis
Cross Sectional Imaging: CT and MRI
    Why?

   Confirm extent of degenerative disease and
    spinal stenosis.
   Search for confirmatory findings in patient with a
    specific radiculopathy if surgery is
    contemplated.
   Occult back pain not responding to conservative
    treatment
   Rule out tumor or infection in appropriate
    patients
Anatomy (
see hieder lecture on radiological anatomy )


 T1                      T2
                                                 Conus
                                                medullaris




                                               Cauda
                                               equina
Anatomy
                            Nucleus
                            pulposis
Nerve root                                Nerve root
in foramen                                in foramen


    disc




              Facet joint
                                       Ligamentum
                                          flavum
Disc disease
   After age 40, most adults have at least
    some desiccation and loss of height of
    lumber discs:
       Low signal on T2 images.
       Posterior or diffuse bulges and protrusions
        are common.
       Jelly-like nuclear material leaks out through
        tear in annular fibers.
Intervertebral disc anatomy



      Nucleus
      pulposus

    Annular fibers



                     T2
Glossary of disc pathology
        terms
   Herniation: nonspecific term subject to
    misinterpretation.
       Not recommended.
   Bulge: diffuse enlargement of disc area
       Very common
       Usually not clinically important
       May contribute to spinal stenosis
   Protrusion: nucleus pulposus pushes focally
    through fibers of annulus fibrosis
       Base wider than apex
       May focally impinge on nerve or thecal sac
Glossary of disc pathology
terms
   Extrusion: nucleus material pushes out
    beyond posterior longitudinal ligament but
    remains in contact with disc space
       Apex wider than base
       Likely to impinge on nerve roots
   Sequestration: Disc fragment isolated from
    parent disc
Glossary of disc pathology
terms
   Localizing terms:
       Central
       Paracentral
       Foraminal
       Lateral
Annular disc bulge




                                        Compressed 8 :1
                Disc bulges diffusely
       Page: 54 of 100                     IM: 54 SE: 3
Broad based disc protrusion




                                                              Compre
                                 Page: 2 of 18                   IM:
                                                             cm
                                                             cm




              Compressed 7 :1             Compressed 7 :1
                                          Compressed
f 11       Page: 6IM:11SE: 201
                   of 6                      IM: 6 SE: 301
             cm
             cm                          cm
                                         cm
Paramedian disc protrusion




         Normal right L5 root   Displaced left L5 root

     This should correlate with a left
            L5 radiculopathy.
Right paramedian disc protrusion




Sag T1   Sag T2      Axial T2
Foraminal Disc Extrusion

 Normal
foramina




           Foraminal Fat Obliterated
Even large disc extrusions will
   resolve spontaneously

      Large extruded disc   Several months later
Spondylosis
   Degenerative disease
       Disc desiccation, bulges and protrusions
       Ligamentum flavum hypertrophy
       Facet arthritis and hypertrophy
       Degenerative spondylolisthesis (seen in 7% of
        asx patients)
       Osteophytes
   All combine to cause stenosis of spaces that
    nerve roots pass through:
       Canal, lateral recess, neural foramen
Spaces for nerve roots
                                    Cauda equina roots in spinal canal




  Neural foramen                      Nerve root in lateral recess


                                                                      Compr
                                                                      Comp
                   Page: 13 of 18                                        IM
                                                                     cm
                                                                     cm
Facet joint arthritis
Spinal stenosis

   Symptoms
       Neurogenic claudication
       Pain relieved with sitting, bending forward
       Progressive pain
       +/- radiculopathy, cauda equina syndrome
       +/- low back pain
   No specific measurement to define it in the
    lumber spine.
   Many improved with nonsurgical therapy
Spinal stenosis

   Contributing factors:
       Disc bulges and protrusions
       Facet arthropathy
       Ligamentum flavum hypertrophy
       Posterior vertebral body osteophytes
         
             Anterior and lateral osteophytes generally not
             important
       Spondylolisthesis
         
             Not spondylolysis alone
Spondylosis
   (Degenerative Disease)




 Sag T2             Axial T2            Axial CT


Annular disc bulge and facet arthropathy cause
                spinal stenosis
Spondylosis causing spinal
                stenosis



                                                                                                                           Compressed 5 :1
                                                                   Compressed 5 :1    Page: 11 of 18                          IM: 11 SE: 5
                                                                                                                          cm
                                                                                                                          cm
                                Page : 8 of 18
                                            18                          IM: 8 SE: 5
                                                                  cm
                                                                  cm




                        Compressed 5 :1
Page: 6 of 11                IM: 6 SE: 3
                       cm
                       cm




                                                                                                        Compressed 5 :1
                                                 Page: 13 of 18
                                                       13                                                  IM: 13 SE: 5
                                                                                                       cm
What does that report mean?
   Facet disease:
       Common in older patients
       May cause pain radiating to hip, simulating
        sciatica
       Predisposes to dynamic instability
       Contributes to spinal and foraminal stenosis
   Mild disc bulges or protrusions
       Very common incidental findings
       Focal sciatica
       Spinal stenosis only if large or in combination
        with other factors (formerly asx stenosed canal)
       Usually not significant unless good correlation
        with sx.
What does that report mean?

   Look for key words and descriptions:
       “spinal stenosis”, “foraminal stenosis”
       Nerve root “displacement”, “compression” or
        “impingement” (see lecture of nomenclature)
   Is a specific root involved?
   Does it correlate with symptoms?
What to order: MRI or CT
   MRI generally preferred
   Contraindications to MRI? — CT is an
    acceptable substitute for disc and bony
    disease, but poor for infection or
    intrathecal tumor.
   MRI — IV contrast only for:
       Suspected infection
       Suspected tumor
       Post-operative spine
         
             Recurrent disc vs. scar tissue
Spinal and Epidural Infection
   High risk populations:
       Immunocompromised
         
             AIDS
         
             Transplant
         
             Chemotherapy
       Endocarditis or sepsis
       Postoperative patients especially with
        hardware (instrumentations)
   Tuberculosis: not necessarily immune
    compromised
Bacterial discitis




                     T1 Axial With GD
T1 Sag   T2 Sag
Tuberculous spondylitis with
       epidural abscess

             Enhancing
             vertebral body
             Non-enhancing
             fluid in disc
             space and
             epidural space




T1 with Gd                    T2
IV drug user– paraspinal
abscess




T1 unenhanced                   T1 enhanced




                T2 unenhanced
Compression fracture:
Benign or malignant?
   Often difficult to distinguish cause of
    acute compression fracture
       History of osteoporosis?
            Osteoporosis may indicate multiple myeloma in
             patient without risk factors.
       History of primary tumor?
       MRI good for survey of marrow at other
        levels to look for other metastases
       Bone scan may serve same function
Compression fracture:
Acute or chronic?

   Many patients have unsuspected old
    compression fractures:
   Cheapest evaluation: check old films!
   Bone scan can prove a fracture is old
       May remain positive for up to two years
       In elderly, may not be positive in first day
   MRI can detect acute marrow edema
Compression Fracture—new or
           old?
 •     New
     •   Hypointense T1
     •   Hyperintense T2
        Easily missed if only T2
             Sequence used
 •     Chronic
     •   Same marrow
         signal as other
         vertebral bodies on
         all pulse
         sequences                 T1   T2
Metastatic disease

     On T1 weighted
      images, discs should
      be darker than
      marrow tissue
     Tumor brighter on T2
      weighted images,
      enhances with
      contrast
     Exception—sclerotic
      prostate metastases
Thank you

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Backache imaging presentation

  • 1. Backache Imaging Presentation Hieder A`ala 601 MUST University
  • 2. Wasted time?  Radiology departments do lots of imaging for low back pain.  X-rays, CT, MRI etc.  How much makes a difference?  Studies show advanced imaging in acute back pain and sciatica doesn’t change outcomes, but improves diagnostic confidence.
  • 3. Causes of back pain and sciatica  Paraspinal muscles  Spondylosis and ligaments  Spinal stenosis  Synovial joints:  Foraminal stenosis  Facet and sacroiliac  Bone disease joints  Tumor  Disc disease  Fracture  Tear of annulus  Infection fibrosis  Epidural abscess  Specific nerve root  discitis impingements
  • 4. Acute Back Pain  2nd most common complaint to primary care physician  >75% of adults will suffer it at some time.  90% will resolve without intervention (or imaging), most without a specific dx.  Among patients with sciatica, only <10% will need surgery.  Whom to image?
  • 5. Back pain imaging — false positives  Most adults over 40 will have degenerative changes on x-rays  MRI shows disc pathology in the majority of adults  Many asymptomatic people have disc bulges and protrusions.  So, imaging is likely to result in an abnormal report.  But correlation between radiographic findings and clinical symptoms is poor.  When to image?
  • 6. When to image in patients with acute back pain?  Most authorities suggest conservative treatment for 4-6 weeks unless there are “red flags”:  Look for historical and physical findings that raise clinical question of infection, tumor, or serious neurological impairment  Even positive findings of degenerative disease like disc extrusions and spinal stenosis are not urgent and will be treated conservatively at first.
  • 7. “Red flags” for early imaging  Severe progressive neurological deficit  Fracture?  Major trauma or minor trauma in osteoporotic pt.  Tumor?  History of cancer, weight loss  Pain worse at night or when supine  Infection?  Recent bacterial infection, immune supression, fever, IVDA
  • 8. Imaging options  Radiography  CT  Better for fine bone detail, arthritis  As good as MRI for acute disc disease  Myelography as adjunct  MRI  Very good for disc, paraspinal pathology, stenosis  Infection  Marrow disorders  Contrast for infection, post-op, tumor  Bone scan  Not for primary imaging in most cases  Discography
  • 9. Radiography  AP and lateral films  Oblique films  Flexion / extension films
  • 10. Radiography  Diagnoses that can be made on AP and lateral:  Spondylolisthesis  Compression fracture  SI joint disease  Disc degeneration  Facet arthritis  Tumor  Infection in disc space
  • 12. Radiography  Diagnosis best made on oblique films:  Spondylolysis Facet joints  Facet arthritis  Foraminal stenosis (cervical spine)
  • 13. Radiography  Diagnosis made with flexion / extension films:  instability
  • 14. Spondylolysis  Stress fracture through pars interarticularis  If bilateral, can cause spondylolisthesis Sagittal reformatted CT spondylolysis spondylolisthesis
  • 15. Cross Sectional Imaging: CT and MRI Why?  Confirm extent of degenerative disease and spinal stenosis.  Search for confirmatory findings in patient with a specific radiculopathy if surgery is contemplated.  Occult back pain not responding to conservative treatment  Rule out tumor or infection in appropriate patients
  • 16. Anatomy ( see hieder lecture on radiological anatomy ) T1 T2 Conus medullaris Cauda equina
  • 17. Anatomy Nucleus pulposis Nerve root Nerve root in foramen in foramen disc Facet joint Ligamentum flavum
  • 18. Disc disease  After age 40, most adults have at least some desiccation and loss of height of lumber discs:  Low signal on T2 images.  Posterior or diffuse bulges and protrusions are common.  Jelly-like nuclear material leaks out through tear in annular fibers.
  • 19. Intervertebral disc anatomy Nucleus pulposus Annular fibers T2
  • 20. Glossary of disc pathology terms  Herniation: nonspecific term subject to misinterpretation.  Not recommended.  Bulge: diffuse enlargement of disc area  Very common  Usually not clinically important  May contribute to spinal stenosis  Protrusion: nucleus pulposus pushes focally through fibers of annulus fibrosis  Base wider than apex  May focally impinge on nerve or thecal sac
  • 21. Glossary of disc pathology terms  Extrusion: nucleus material pushes out beyond posterior longitudinal ligament but remains in contact with disc space  Apex wider than base  Likely to impinge on nerve roots  Sequestration: Disc fragment isolated from parent disc
  • 22. Glossary of disc pathology terms  Localizing terms:  Central  Paracentral  Foraminal  Lateral
  • 23. Annular disc bulge Compressed 8 :1 Disc bulges diffusely Page: 54 of 100 IM: 54 SE: 3
  • 24. Broad based disc protrusion Compre Page: 2 of 18 IM: cm cm Compressed 7 :1 Compressed 7 :1 Compressed f 11 Page: 6IM:11SE: 201 of 6 IM: 6 SE: 301 cm cm cm cm
  • 25. Paramedian disc protrusion Normal right L5 root Displaced left L5 root This should correlate with a left L5 radiculopathy.
  • 26. Right paramedian disc protrusion Sag T1 Sag T2 Axial T2
  • 27. Foraminal Disc Extrusion Normal foramina Foraminal Fat Obliterated
  • 28. Even large disc extrusions will resolve spontaneously Large extruded disc Several months later
  • 29. Spondylosis  Degenerative disease  Disc desiccation, bulges and protrusions  Ligamentum flavum hypertrophy  Facet arthritis and hypertrophy  Degenerative spondylolisthesis (seen in 7% of asx patients)  Osteophytes  All combine to cause stenosis of spaces that nerve roots pass through:  Canal, lateral recess, neural foramen
  • 30. Spaces for nerve roots Cauda equina roots in spinal canal Neural foramen Nerve root in lateral recess Compr Comp Page: 13 of 18 IM cm cm
  • 32. Spinal stenosis  Symptoms  Neurogenic claudication  Pain relieved with sitting, bending forward  Progressive pain  +/- radiculopathy, cauda equina syndrome  +/- low back pain  No specific measurement to define it in the lumber spine.  Many improved with nonsurgical therapy
  • 33. Spinal stenosis  Contributing factors:  Disc bulges and protrusions  Facet arthropathy  Ligamentum flavum hypertrophy  Posterior vertebral body osteophytes  Anterior and lateral osteophytes generally not important  Spondylolisthesis  Not spondylolysis alone
  • 34. Spondylosis (Degenerative Disease) Sag T2 Axial T2 Axial CT Annular disc bulge and facet arthropathy cause spinal stenosis
  • 35. Spondylosis causing spinal stenosis Compressed 5 :1 Compressed 5 :1 Page: 11 of 18 IM: 11 SE: 5 cm cm Page : 8 of 18 18 IM: 8 SE: 5 cm cm Compressed 5 :1 Page: 6 of 11 IM: 6 SE: 3 cm cm Compressed 5 :1 Page: 13 of 18 13 IM: 13 SE: 5 cm
  • 36. What does that report mean?  Facet disease:  Common in older patients  May cause pain radiating to hip, simulating sciatica  Predisposes to dynamic instability  Contributes to spinal and foraminal stenosis  Mild disc bulges or protrusions  Very common incidental findings  Focal sciatica  Spinal stenosis only if large or in combination with other factors (formerly asx stenosed canal)  Usually not significant unless good correlation with sx.
  • 37. What does that report mean?  Look for key words and descriptions:  “spinal stenosis”, “foraminal stenosis”  Nerve root “displacement”, “compression” or “impingement” (see lecture of nomenclature)  Is a specific root involved?  Does it correlate with symptoms?
  • 38. What to order: MRI or CT  MRI generally preferred  Contraindications to MRI? — CT is an acceptable substitute for disc and bony disease, but poor for infection or intrathecal tumor.  MRI — IV contrast only for:  Suspected infection  Suspected tumor  Post-operative spine  Recurrent disc vs. scar tissue
  • 39. Spinal and Epidural Infection  High risk populations:  Immunocompromised  AIDS  Transplant  Chemotherapy  Endocarditis or sepsis  Postoperative patients especially with hardware (instrumentations)  Tuberculosis: not necessarily immune compromised
  • 40. Bacterial discitis T1 Axial With GD T1 Sag T2 Sag
  • 41. Tuberculous spondylitis with epidural abscess Enhancing vertebral body Non-enhancing fluid in disc space and epidural space T1 with Gd T2
  • 42. IV drug user– paraspinal abscess T1 unenhanced T1 enhanced T2 unenhanced
  • 43. Compression fracture: Benign or malignant?  Often difficult to distinguish cause of acute compression fracture  History of osteoporosis?  Osteoporosis may indicate multiple myeloma in patient without risk factors.  History of primary tumor?  MRI good for survey of marrow at other levels to look for other metastases  Bone scan may serve same function
  • 44. Compression fracture: Acute or chronic?  Many patients have unsuspected old compression fractures:  Cheapest evaluation: check old films!  Bone scan can prove a fracture is old  May remain positive for up to two years  In elderly, may not be positive in first day  MRI can detect acute marrow edema
  • 45. Compression Fracture—new or old? • New • Hypointense T1 • Hyperintense T2 Easily missed if only T2 Sequence used • Chronic • Same marrow signal as other vertebral bodies on all pulse sequences T1 T2
  • 46. Metastatic disease  On T1 weighted images, discs should be darker than marrow tissue  Tumor brighter on T2 weighted images, enhances with contrast  Exception—sclerotic prostate metastases