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B2
RIBOFLAVIN
•
3
Riboflavin (B2)
It is also called as beauty vitamin.
 it is yellowish green fluorescent compound
soluble in water.
The word riboflavin is derived from 2 sources
ribose – means many ribose sugar found in
several vitamins
flavin – yellow.
 It is widely involved in oxidation-reduction
reaction.
Riboflavin ( B2) MUHAMMAD MUSTANSAR
Riboflavin ( B2) MUHAMMAD MUSTANSAR
Riboflavin ( B2) MUHAMMAD MUSTANSAR
Structure & function
8
Sources
• Plant :
 Rice
 Bajra
 Pulses- soybeans
 Vegetables – spinach
cauliflower
 brinjal
• Animals:-
 liver of sheep
 eggs
 Mutton
 Prawn
 milk
9
10
Absorption & excretion
It is readily absorbed from intestinal tract
It is carried to tissue of the body &
incorporated into the cell enzymes.
It is stored in liver, kidney & heart.
Excretion – urine & sweat
Riboflavin ( B2) MUHAMMAD MUSTANSAR
BIOCHEMICAL FUNCTIONS OF
RIBOFLAVIN:
A- Biochemical role of FMN as a coenzyme
1. FMN as a part of redox potential
2. FMN is a coenzyme for L-amino acid
oxidases:
3. FMN being a part of Cut. C reductase
4. FMN also accepts 2H+
from NADH+H+
5. FMN is a coenzyme for Warburg’s yellow
enzyme [a component of respiratory
chain]
B- FAD is a coenzyme for the following
enzyme:
Like FMN, FAD is also is a part of
mitochondrial respiratory chain
1. D-aminoacid oxidases: The enzymes
catalyze reaction similar to L-aminoacid
oxidases but with FAD as coenzyme.
2. Aldehyde oxidase
3. Acyl-CoA dehydrogenase of the β
oxidation of fatty acids
4. Succinate dehydrogenase, an enzyme of
citric acids cycle and converts succinate
to fumarate in mitochondria
5. Xanthine oxidase present in milk, small
intestine, kidney converts purine bases to
uric acid
6. Glucose oxidase prepared from fungi
7. Glycine oxidase which oxidative
deaminates glycine to glyoxylic acid and
ammonia
Riboflavin-B2
Involved in energy metabolism; part of two
co- enzymes,FMN and FAD
Participate in citric acid cycle and beta
oxidation and electron transport
Remove ammonia during deamination of
some amino- acids
19
Daily requirement
Men – 1.5mg
women – 1.2 mg
Pregnancy and lactation – 2 to 2.3 mg .
Children – 1.3mg.
20
Functions
It is essential for normal growth.
Metabolism – It is involved in the metabolism
of carbohydrates, fat & proteins.
Digestion – it helps in digestion
Nervous system – it helps in proper
functioning of Nervous system
RIBOFALVIN IMPORTANCE
22
Deficiency
Ocular changes-
it consists of corneal vasodilatation,
superficial & interstitial keratitis.
Skin & nails –
it may also result in dull or oily hair. Oily
skin, premature wrinkle on face.
23
Deficiency
sore throat
cheliosis
glossitis
seborrheic dermatitis
anemia
Riboflavin ( B2) MUHAMMAD MUSTANSAR
SYMPTOMS OF RIBOFLAVIN
DEFICIENCY
• Stomatitis
• Anemia
• Swollen and dark tongue
• Angular chelosis: cracks in corners of
mouth and lips
26
• Chapping &
fissuring of lips
CHEILOSIS
GLOSSITIS
• Inflammmed
• Red beefy tongue
Riboflavin ( B2) MUHAMMAD MUSTANSAR
28
SEBORRHEIC DERMATITIS
 Red, scaly, itchy rashes
seen on
• scalp
• sides of nose
• eyebrows
• eyelids
• skin behind ears, middle of
chest
29
Oral manifestation
Tongue:- in severe cases the tongue becomes
glazed & smooth due to complete atrophy of
the papillae.
Lips:- becomes red & shiny because of
desquamation of epithelium.
30
Management
Riboflavin 25,000 to 50,000 mcg is given
daily in divided doses.
VITAMIN B2 (Riboflavin)
SOURCES:
 Yeast
 Whole grain
 Dry beans and pea
 Green vegetables
RDA: 1.5-1.8 mg/day in adults
FUNCTIONS:
In two active forms FMN and FAD serves as coenzyme in various reactions
DEFICIENCY
 Cheilosis-fissuring at angle of the mouth
 Glossitis-tongue smooth and purplish
 Seborrhagic Dermatitis:scaly,greasy,desquamation
 Eyes: corneal vascularization
Chronic alcoholics are susceptible to deficiencies.

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Riboflavin ( B2) MUHAMMAD MUSTANSAR

  • 1. 1
  • 3. 3 Riboflavin (B2) It is also called as beauty vitamin.  it is yellowish green fluorescent compound soluble in water. The word riboflavin is derived from 2 sources ribose – means many ribose sugar found in several vitamins flavin – yellow.  It is widely involved in oxidation-reduction reaction.
  • 8. 8 Sources • Plant :  Rice  Bajra  Pulses- soybeans  Vegetables – spinach cauliflower  brinjal • Animals:-  liver of sheep  eggs  Mutton  Prawn  milk
  • 9. 9
  • 10. 10 Absorption & excretion It is readily absorbed from intestinal tract It is carried to tissue of the body & incorporated into the cell enzymes. It is stored in liver, kidney & heart. Excretion – urine & sweat
  • 12. BIOCHEMICAL FUNCTIONS OF RIBOFLAVIN: A- Biochemical role of FMN as a coenzyme 1. FMN as a part of redox potential 2. FMN is a coenzyme for L-amino acid oxidases:
  • 13. 3. FMN being a part of Cut. C reductase 4. FMN also accepts 2H+ from NADH+H+ 5. FMN is a coenzyme for Warburg’s yellow enzyme [a component of respiratory chain]
  • 14. B- FAD is a coenzyme for the following enzyme: Like FMN, FAD is also is a part of mitochondrial respiratory chain
  • 15. 1. D-aminoacid oxidases: The enzymes catalyze reaction similar to L-aminoacid oxidases but with FAD as coenzyme. 2. Aldehyde oxidase 3. Acyl-CoA dehydrogenase of the β oxidation of fatty acids
  • 16. 4. Succinate dehydrogenase, an enzyme of citric acids cycle and converts succinate to fumarate in mitochondria 5. Xanthine oxidase present in milk, small intestine, kidney converts purine bases to uric acid
  • 17. 6. Glucose oxidase prepared from fungi 7. Glycine oxidase which oxidative deaminates glycine to glyoxylic acid and ammonia
  • 18. Riboflavin-B2 Involved in energy metabolism; part of two co- enzymes,FMN and FAD Participate in citric acid cycle and beta oxidation and electron transport Remove ammonia during deamination of some amino- acids
  • 19. 19 Daily requirement Men – 1.5mg women – 1.2 mg Pregnancy and lactation – 2 to 2.3 mg . Children – 1.3mg.
  • 20. 20 Functions It is essential for normal growth. Metabolism – It is involved in the metabolism of carbohydrates, fat & proteins. Digestion – it helps in digestion Nervous system – it helps in proper functioning of Nervous system
  • 22. 22 Deficiency Ocular changes- it consists of corneal vasodilatation, superficial & interstitial keratitis. Skin & nails – it may also result in dull or oily hair. Oily skin, premature wrinkle on face.
  • 25. SYMPTOMS OF RIBOFLAVIN DEFICIENCY • Stomatitis • Anemia • Swollen and dark tongue • Angular chelosis: cracks in corners of mouth and lips
  • 26. 26 • Chapping & fissuring of lips CHEILOSIS GLOSSITIS • Inflammmed • Red beefy tongue
  • 28. 28 SEBORRHEIC DERMATITIS  Red, scaly, itchy rashes seen on • scalp • sides of nose • eyebrows • eyelids • skin behind ears, middle of chest
  • 29. 29 Oral manifestation Tongue:- in severe cases the tongue becomes glazed & smooth due to complete atrophy of the papillae. Lips:- becomes red & shiny because of desquamation of epithelium.
  • 30. 30 Management Riboflavin 25,000 to 50,000 mcg is given daily in divided doses.
  • 31. VITAMIN B2 (Riboflavin) SOURCES:  Yeast  Whole grain  Dry beans and pea  Green vegetables RDA: 1.5-1.8 mg/day in adults FUNCTIONS: In two active forms FMN and FAD serves as coenzyme in various reactions DEFICIENCY  Cheilosis-fissuring at angle of the mouth  Glossitis-tongue smooth and purplish  Seborrhagic Dermatitis:scaly,greasy,desquamation  Eyes: corneal vascularization Chronic alcoholics are susceptible to deficiencies.