ACh synthesis and neurotransmission
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The document describes the process of neurotransmission at the neuromuscular junction. It explains that an action potential arrives at the synaptic terminal and causes vesicles containing acetylcholine to fuse with the neuronal membrane and release acetylcholine into the synaptic cleft. The acetylcholine then binds to receptors on the motor end plate, increasing sodium permeability and triggering an action potential in the muscle fiber. Acetylcholinesterase then breaks down the acetylcholine.
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ACh synthesis and neurotransmission
- 1. Acetyl co A +Choline Cholineacetylase Ach synthesis Main store Mobilization pool Immediately available pool ACh->Acetic acid+choline Depolarisation->EPP->MAP
- 2. Action potential Arrival of an action potential at the synaptic terminal Axon Arriving action potential Synaptic terminal Sarcolemma Vesicles ACh Synaptic cleft Sarcolemma of motor end plate AChE molecules ACh receptor site ACh binding at the motor and plate Release of acetylcholine Vesicles in the synaptic terminal fuse with the neuronal membrane and dump their contents into the synaptic cleft. Muscle fiber The binding of ACh to the receptors increases the membrane permeability to sodium ions. Sodium ions then rush into the cell. Appearance of an action potential in the sarcolemma An action potential spreads across the surface of the sarcolemma. While this occurs, AChE removes the ACh. Action potential Na+ Na+ Na+
- 5. Action potential Arrival of an action potential at the synaptic terminal Axon Arriving action potential Synaptic terminal Sarcolemma Vesicles ACh Synaptic cleft Sarcolemma of motor end plate AChE molecules ACh receptor site ACh binding at the motor and plate Release of acetylcholine Vesicles in the synaptic terminal fuse with the neuronal membrane and dump their contents into the synaptic cleft. Muscle fiber The binding of ACh to the receptors increases the membrane permeability to sodium ions. Sodium ions then rush into the cell. Appearance of an action potential in the sarcolemma An action potential spreads across the surface of the sarcolemma. While this occurs, AChE removes the ACh. Action potential Na+ Na+ Na+
- 6. Action potential Arrival of an action potential at the synaptic terminal Axon Arriving action potential Synaptic terminal Sarcolemma Vesicles ACh Synaptic cleft Sarcolemma of motor end plate AChE molecules ACh receptor site ACh binding at the motor and plate Release of acetylcholine Vesicles in the synaptic terminal fuse with the neuronal membrane and dump their contents into the synaptic cleft. Muscle fiber The binding of ACh to the receptors increases the membrane permeability to sodium ions. Sodium ions then rush into the cell. Appearance of an action potential in the sarcolemma An action potential spreads across the surface of the sarcolemma. While this occurs, AChE removes the ACh. Action potential Na+ Na+ Na+
- 11. Myasthenia Gravis Repetitive Nerve Stimulation
- 15. baseline Post exercise 2 minutes 3 minutes Repeat exercise
- 16. Single Fiber EMG Myasthenia Gravis
- 17. Action potential Arrival of an action potential at the synaptic terminal Axon Arriving action potential Synaptic terminal Sarcolemma Vesicles ACh Synaptic cleft Sarcolemma of motor end plate AChE molecules ACh receptor site ACh binding at the motor and plate Release of acetylcholine Vesicles in the synaptic terminal fuse with the neuronal membrane and dump their contents into the synaptic cleft. Muscle fiber The binding of ACh to the receptors increases the membrane permeability to sodium ions. Sodium ions then rush into the cell. Appearance of an action potential in the sarcolemma An action potential spreads across the surface of the sarcolemma. While this occurs, AChE removes the ACh. Action potential Na+ Na+ Na+
- 18. Action potential Arrival of an action potential at the synaptic terminal Axon Arriving action potential Synaptic terminal Sarcolemma Vesicles ACh Synaptic cleft Sarcolemma of motor end plate AChE molecules ACh receptor site ACh binding at the motor and plate Release of acetylcholine Vesicles in the synaptic terminal fuse with the neuronal membrane and dump their contents into the synaptic cleft. Muscle fiber The binding of ACh to the receptors increases the membrane permeability to sodium ions. Sodium ions then rush into the cell. Appearance of an action potential in the sarcolemma An action potential spreads across the surface of the sarcolemma. While this occurs, AChE removes the ACh. Action potential Na+ Na+ Na+
- 27. Action potential Arrival of an action potential at the synaptic terminal Axon Arriving action potential Synaptic terminal Sarcolemma Vesicles ACh Synaptic cleft Sarcolemma of motor end plate AChE molecules ACh receptor site ACh binding at the motor and plate Release of acetylcholine Vesicles in the synaptic terminal fuse with the neuronal membrane and dump their contents into the synaptic cleft. Muscle fiber The binding of ACh to the receptors increases the membrane permeability to sodium ions. Sodium ions then rush into the cell. Appearance of an action potential in the sarcolemma An action potential spreads across the surface of the sarcolemma. While this occurs, AChE removes the ACh. Action potential Na+ Na+ Na+
- 28. Action potential Arrival of an action potential at the synaptic terminal Axon Arriving action potential Synaptic terminal Sarcolemma Vesicles ACh Synaptic cleft Sarcolemma of motor end plate AChE molecules ACh receptor site ACh binding at the motor and plate Release of acetylcholine Vesicles in the synaptic terminal fuse with the neuronal membrane and dump their contents into the synaptic cleft. Muscle fiber The binding of ACh to the receptors increases the membrane permeability to sodium ions. Sodium ions then rush into the cell. Appearance of an action potential in the sarcolemma An action potential spreads across the surface of the sarcolemma. While this occurs, AChE removes the ACh. Action potential Na+ Na+ Na+
- 30. SCS
- 34. 20 Hz
- 36. Summary