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You are Only As Oldas Your Arteries!ByDavid A Steenblock, DO26381 Crown Valley ParkwayMission Viejo, CA 92691800-300-1063www.stemcell.md,[object Object]
In tribute to Sir William Osler, M.D., First Director of Medicine, Johns Hopkins Hospital“A man is only as old as his arteries.”,[object Object]
Arteriosclerosis“Hardening of the Arteries”,[object Object],[object Object]
 Creates ischemic conditions for the heart, brain, legs, kidneys and other organs, resulting in disease and degeneration.
 Athero from the Greek word “gruel”		(cholesterol/fat deposits),[object Object],	  Sclerosis from Greek for “hardness”,[object Object],		(collagen calcification, usually 70% of plaque),[object Object]
Major Risk Factors for Arteriosclerosis,[object Object],[object Object]
 Smoking
 Serum total cholesterol
 Diabetes
 Obesity
 Sedentary Lifestyle
 Menopause in women
 “sticky platelets”
 Dietary deficiencies,[object Object]
Red Blood cells(erythrocytes) transport oxygen to the cells and carry carbon dioxide (cellular waste) back to the lungs to be exhaled.,[object Object]
Arteries are large blood vessels that carry oxygenated blood from the heart to the brain, limbs and organs.,[object Object]
Veins are large blood vessels that carry de-oxygenated blood back to the heart.,[object Object]
Capillaries are microscopic blood vessels having only one layer of endothelial cells as a wall so that oxygen and nutrients can move into the cells and carbon dioxide can move into capillaries and be carried away.,[object Object]
The Artery Wall should expand and contract with the heartbeat.,[object Object],Adventitia – outer wall            	(connective tissue),[object Object],Media – elastic middle layer  (smooth muscle cells),[object Object],Intima – endothelial layer  	(inflammation creates 	intimal thickening),[object Object],Lumen – opening where blood flows,[object Object]
Endothelial Cells(cells of the blood vessel walls),[object Object],[object Object]
 Sense the blood pressure and flow rate and release 	nitric oxide to relax the vessel walls to allow 	more blood to flow through.
 Sense vascular injury and stimulates growth 	factors to migrate to the area of injury.
 Signal blood cells to stick to the endothelial cells 	(platelet aggregation/clotting) to prevent the 	loss of blood.,[object Object]
Major Causes of Endothelial Injury,[object Object],[object Object]
 Hypertension		-Sympathetic neurotransmitters,[object Object],		- Stress induced hormones,[object Object],[object Object]
 Chemical toxins (pesticides, etc)
 Heavy metals (mercury, lead, cadmium)
 Tobacco
 Cholesterol, especially oxidized LDL and VLDL
 Free Radicals – unpaired electrons,[object Object]
 Homocysteine
 Low dietary calcium - Hyperparathyroidism,[object Object]
 The injury  damages the endothelial cells allowing free radicals, lipids, calcium and cholesterol to penetrate into the inner muscular (middle) layer
 The free radicals oxidize LDL and VLDL cholesterol, creating a chain reaction of cellular damage.
 Macrophages invade the area to digest the rancid lipids, becoming “foam cells.”,[object Object]
Foam Cells,[object Object],[object Object]
 Earliest lesion in arterioslcerosis
 Mostly lipid engulfed macrophages with occasional lipid filled smooth muscle cells
 Seen very early – age 3 and above,[object Object]
 This combination of foam cells, calcification, and lipids is called “atherosclerotic plaque.”
 If the plaque material ruptures, platelets accumulate and create blood clots on the inner surface of the blood vessel wall.,[object Object]
An Aneurysm of the Abdominal Aorta,[object Object]
As the arteries become clogged- blood, oxygen and nutrients are unable to reach the heart, brain, kidneys and other organs.,[object Object],A heart attack or ,[object Object],stroke is the result ,[object Object],of these blockages!,[object Object]
Arteriosclerosis and Systemic Disease,[object Object]
Ischemia – lack of blood flowHypoxia – lack of oxygen,[object Object],Most diseases can be attributed directly or indirectly to ischemia, a lack of ,[object Object],		     blood flow to the cell.,[object Object],Reducing the risk factors for cardiovascular disease reduces other atherosclerotic disease 		outcomes as well.,[object Object]
Ischemia and the Heart,[object Object],Since oxygen is the fuel needed for muscles to contract, a reduction in blood flow and oxygen to the heart interferes with its contractions.  A heart muscle starved of oxygen produces pain (angina) and is less able to pump blood efficiently to the body, especially during exercise (shortness of breath, dizziness, headache, pain in the leg muscles).,[object Object]
Arteriosclerosis and Heart Disease,[object Object],[object Object]
Arrythmia (irregularities such as PVC’s, atrial fibrillation, skips, flutters, etc)
 Angina (chest and/or left arm pain, etc)
 Shortness of breath
Blockage of the left main coronary artery is the worst and often kills.(American Journal of Medicine, 1996, 101 (Suppl 4A): 17S-24S).,[object Object]
Arteriosclerosis and the Brain,[object Object],		1) Causes transient ischemic attacks,[object Object],	2) Causes the majority of all strokes,[object Object],	3) Stroke is the third leading cause of death in USA,[object Object],	4) Lack of oxygen is a cause of memory loss, loss of clear    	thinking, brain fog, poor mental functioning, confusion, 	forgetfulness and difficulty concentrating (cognitive 	dysfunction).,[object Object],	5) Causes vascular dementia while most cases of    	Alzheimer’s are partially due to oxygen deficiency.,[object Object],	6) Lack of oxygen occurs at night in a very great number 	of people who don’t realize they have the problem.  All 	of the problems listed under number 4 can occur.  Insist 	that your doctor order a Nocturnal oximetry test!  It is free 	and could save your life!!!!!!!!,[object Object]
Alzheimer’s Disease,[object Object],   Chronic cerebrovascular ischemia ,[object Object],(chronic lack of oxygen to the brain) produces an increased 	risk for the development of Alzheimer’s Disease, ,[object Object],with observed deficits in spatial memory (CA1 and posterior parietal cortex), visually guided movements (superior colliculus and secondary visual cortex), motor coordination (red nucleus), and escape behavior (central gray).,[object Object],		          (Neurobiology of Aging 21: 225-233, 2000),[object Object]
Alzheimer’s Disease(continued),[object Object],Vascular risk factors linked to cerebrovascular disease and stroke in the elderly significantly increase the risk of developing Alzheimer’s Disease.  These include atherosclerosis, atrial fibrillation, coronary artery disease, hypertension, and diabetes mellitus.  The authors report that 60-90% of AD autopsy cases exhibit cerebrovascular pathology. ,[object Object],		(Neurobiology of Aging, 21: 321-330, 2000),[object Object]
Ischemia and Parkinsons’ Disease,[object Object],A transient reduction in cerebral blood flow in rats produces long-lasting degeneration and dysfunction in the dopamine system and eventually the partial loss of striatal D1RmRNA. ,[object Object],			(Brain Research, 851, 235-246, 1999),[object Object]
Ischemia andMacular Degeneration,[object Object],Macular degeneration is the leading cause of irreversible visual loss in the United States.  The authors used Doppler Imaging to show reduced blood flow in the central retinal artery.,[object Object],	(American Journal of Ophthalmology, 128: 75-80, 1999),[object Object]
Macular degeneration,[object Object],Improved greatly with hyperbaric oxygen, external counterpulsation, periodic acceleration therapy, chelation therapy, night time oxygen, eradication of chronic sinusitis, bone marrow and or fat stem cells.  All of these work by increasing the oxygen to the macula!,[object Object]
Ischemia and Sexual Performance,[object Object],Atherosclerosis is a risk factor for erectile dysfunction (ED).  Future therapeutic targets to treat or prevent ED may include the reduction of the atherosclerotic plaque size and progression. Stem cells now are being used successfully to treat erectile dysfunction!,[object Object]
Ischemia andArthritis,[object Object],Jonsson and coworkers found an increased prevalence of atherosclerosis in patients with medium term rheumatoid arthritis.,[object Object],(J Rheumatol, 28(12): 2597-602, 2001),[object Object]
Kidney Failure,[object Object],Homma and coworkers showed marked atherosclerosis associated with end-stage renal disease.,[object Object],(American Journal of Nephrology, 21(5): 415-9, 2001).,[object Object]
Renal Arteries andCoronary Arteries,[object Object],Shen and coworkers found a prevalence of renal artery stenosis in patients with coronary artery disease.,[object Object],(Zhonghua Nei Ke Za Hi, 40(8): 521-4, 2001 – Chinese),[object Object]
Our Program includes:,[object Object],[object Object]
Hyperbaric Oxygen Therapy
 Pulsed Electromagnetic Therapy
 External Counterpulsation
 High Altitude Cardiovascular Training
Periodic Acceleration Therapy
 Chelation Therapy
 Biofeedback/Neuro-biofeedback
 Nutritional and Hormonal Therapies
 Stimulation of Endogenous Stem Cells,[object Object]
Benefits,[object Object],The combination of breathing oxygen through the mask and the chamber pressure causes two to three times the oxygen to be delivered to the blood vessel walls and organ tissues compared to breathing oxygen by the mask alone.,[object Object]
Benefits (continued),[object Object],The results include:,[object Object],[object Object]
Releases Stem Cells from bones
New blood vessel formation
 Improved infection control
 Renewal of injured cells and organs
 Elimination of toxic substances,[object Object]
    (Arterioscler Thromb Vasc Biol, 2000, 20(6): 1637-43),[object Object]
Hyperbaric Oxygen is effective for the following:,[object Object],[object Object]
 Air embolism
 Poisoning
 Treatment of infections
 Non-healing wounds in Plastic and reconstructive surgery
 Traumatic injuries

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Atherosclerosis