Etiology of Head and neck malignancy
•Télécharger en tant que ODP, PDF•
7 j'aime•1,304 vues
![Introduction ,[object Object]](data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7)
Recommandé
Contenu connexe
Tendances
Tendances (20)
En vedette
En vedette (20)
Similaire à Etiology of Head and neck malignancy
Similaire à Etiology of Head and neck malignancy (20)
Plus de Balasubramanian Thiagarajan
Plus de Balasubramanian Thiagarajan (20)
Dernier
Dernier (20)
Etiology of Head and neck malignancy
- 1. Etiology of Head & Neck malignancies Dr. T. Balasubramanian
- 3. More than 90% of head and neck cancers are of squamous type
- 4. These cancers are difficult to treat because of the proximity of vital structure like great vessels
- 5. Early diagnosis will go a long way in improving the prognosis
- 7. Alcohol
- 9. Nitrosamines
- 10. Viral infections (EB virus)
- 11. Radioactive Polonium – 210
- 12. Canabis
- 13. Wood dust (African mahogany)
- 15. Concomittent use of tobacco and alcohol increases the risk of head and neck malignancy by 4 times
- 16. Risk also increases proportionate to the number of cigarettes smoked per day
- 17. Air processed dark tobacco has twice the risk when compared to light colored ones
- 19. Method of tobacco use is also relevent in the context of the subsite involved. Palatal malignancy is common in tobacco chewers while lung malignancies are common in smokers
- 20. Common carcinogen found in cigarette include: Polycyclic hydrocarbons, Nitrosamines and radioacive polonium - 210
- 22. Cannabis contains larger quantities of coal tar and aromatic hydrocarbons than tobacco
- 23. Cannabis is highly lipid soluble and hence permeates across tissue barriers.
- 25. It potentiates the carcinogenic effects of smoking tobacco as it is an excellent solvent.
- 26. It dissolves the carcinogens present in tobacco thereby facilitating tissue permeation of these substances
- 27. It also affects the synthesis of retenoids in the body. These retinoids have cancer protective function
- 29. Nitrosamine content of Beer is more than other alcoholic beverages.
- 30. Wine contains resveratrol which is a potent cancer preventing agent. Red wine contains large amounts of Resveratrol and hence is very good for health
- 34. These viruses can be classified into high risk, medium risk and low risk types
- 35. High risk – types 16 & 18
- 36. Medium risk – types 31 & 33
- 37. Low risk – types 6 & 11
- 38. EB virus is another virus associated with head and neck malignancy (NPC)
- 40. Juvenile respiratory papilloma is caused by high risk papilloma strain hence malignant transformation is common in this age group
- 41. PCR studies have demonstrated high risk strain of papilloma viruses in head and neck malignant tumors
- 43. UV light component of sunlight is the culprit
- 44. Melanoma / squamous cell caricinoma of skin and lips can be caused by UV radiations from sunlight.
- 46. Workers in Asbestos factories
- 47. Workers in wood industry using African Mahogany type of wood
- 49. Salted fish diet & Nasopharyngeal carcinoma
- 53. Inactivation of tumor suppressor genes
- 54. Mutations could be point mutations, deletions or amplification of segments of DNA
- 55. Mutations causing failure of detoxification of carcinogens
- 57. These enzymes are involved in the metabolism of carcinogens
- 58. N acetyl transferase & Gluthathione s transferase are examples of enzymes showing polymorphism
- 60. These mutations inturn can predispose to head and neck malignancy
- 61. Previously irradiation was used to treat TB cervical nodes. These patients later became prone for head & neck malignancies
- 62. Thank you