2. . “SEPSIS AT ITS INCEPTION IS DIFFICULT TO RECOGNIZE BUT EASY TO TREAT; LEFT UNATTENDED IT BECOMES EASY TO RECOGNIZE BUT DIFFICULT TO TREAT” Machiavelli
6. SYSTEMIC INFLAMMATORY RESPONSE SYNDROME Generalized inflammatory response of the body to a variety of clinical conditions including infection, but not limited to infection 2 or more of the following
15. MODS Presence of altered organ function lasting for > 24 hrs in an acutely ill patient, such that homeostasis cant be maintained without intervention.
35. STEROIDS Poorly responsive hypotension Hydrocortisone > dexamethasone Hydrocortisone <300 mg / day Fludrocortisone 50 µg OD optional Weaned when no vasopressors No steroid if no shock
50. OUTCOME IMPROVED BY Early goal directed therapy Lung protective ventilation Appropriate antibiotic coverage Activated protein C Tight control of sugars 80-100mg/dl Steroids
51. A clinician, armed with the sepsis bundles, attacks the three heads of severe sepsis: hypotension, hypoperfusion and organ dysfunction
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