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Marc Dusseiller Dusjagr
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Dusjagr nano filia_size
1.
NanoHacking: Converging Life and Tech at the Nanoscale SEEING THINGS – But how big/small is it? Dr. Marc R. Dusseiller aka dusjagr www.dusseiller.ch/labs
2.
The Size of Things
3.
Small seems to be the state of the art
4.
Why are we so big? “Why must our
bodies be so large compared with the atom?” Erwin Schrödinger, "What Is Life? The Physical Aspect of the Living Cell ", 1944 Austrian/Irish physicist and Nobel Laureate (1887 - 1961)
5.
The Size of Things
6.
Längenskalen in der Biologie
7.
Computermodels Atome, Kristalle und kleine Moleküle
8.
Moleküle Lipid Moleküle Computermodels Wichtiger Bestandteil der
Zellmembran
9.
DNA ● Trägerin der Erbinformation ● 4 Nukleotiden ● GATC ● Doppelhelix 1 Umdrehung = 10 Basenpaare = 3.4 nm Breite = 2 nm
10.
DNA ● Was wäre die theoretische Länge des menschlichen Genoms? – Schätzungen...
11.
DNA ● Was wäre die theoretische Länge des menschlichen Genoms? – – 75% noncoding regions with unknown function – 3'200'000'000 Basenpaare – Diploides Genom auf 23 Chromosomen – ● 27'000 oder 150'000 Gene, weiss man doch nicht so genau... Frauen haben offenbar eine längere DNA :) 0,34 nm/bp * 6,4 Mrd bp = 2,18 Mrd nm = 2,18 m
12.
DNA als NanoLEGO Baukasten Steifes Polymer ● Negative Ladung ● SelfAssembly Computermodels ●
13.
Proteine Entstehen durch Translation von mRNA Computermodels ●
14.
Protein Komplexe Zb Ribosom – Besteht aus Proteinen und Ribonukleinsäuren – Durchmesser 25 nm Computermodels ●
15.
Computermodels Viren
16.
Computermodels Bakterien
17.
Computermodels Zellen
18.
Zellen im Verbund ● Extrazelluläre Matrix Plastisches und bewegtes Gefüge Computermodels ●
19.
Einzellige Organismen Computermodels Pantoffeltierchen, Paramecium (Ciliate) Amoebae
20.
Multicellular Microorganisms Rotifers (1000 Cells) Tardigrada, Bärtierchen, war 2007 im Weltraum, ESA Projekt TARDIS Computermodels Caenorhabditis elegans, Fadenwurm
21.
Seeing Things
22.
Looking at Things
23.
Seeing with light aka your eyes
24.
Seeing with light aka your eyes
25.
µ Zivalice Laser Projector A small drop of pond water acts as a lens, shine a laser through it and see!
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