This document describes a wireless telemetry system called rodentPACK2 that is used to acquire EEG and other biopotential and physiological data from rodents. It consists of a permanently implanted skull connector, a transmitter connected during recordings, and a receiver that can monitor up to 4 animals simultaneously. The system transmits up to 9 signals including EEG, ECG, temperature and activity data. Accompanying software allows sleep scoring, seizure detection, and power spectral analysis of the EEG data. Video can also be integrated to observe associated behaviors.

1. telemetry.emka.fr
Acquisition and analysis for neurologic data
physiology
pharmacology
toxicology

2. 2
Rodent EEG telemetry
Wireless, low cost, head-mounted EEG for rats
rodentPACK2 is a wireless, head-mounted telemetry system for
rodents. It enables the acquisition of EEG and other biopotential
signals, as well as temperature and activity/positional data -
applications are varied, e.g. sleep and epilepsy studies, ECG recording.
rodentPACK2 transmits data via radiotelemetry, offering a well-tolerated,
humane alternative to tethered EEG.
Direct inputs from the device to cortical and deep brain regions provide
a high signal to noise ratio, facilitating the detection of EEG events.
rodentPACK2 consists of:
»» a skull connector permanently implanted
»» a transmitter, connected to skull implant only during recordings
»» a receiver for 4 animals
9 signals are acquired for each rodentPACK2
»» 4 biopotentials (EEG, ECG, EMG), sampled at up to 1000Hz
»» x/y/z accelerations sampled at 50Hz
»» global acceleration (computed from 3 axes), for activity assessment
»» core temperature
Advantages
»» compact, light and noise free transmitter
»» no refurbishment, batteries cost less than 2$/recording
»» same transmitter may be used on any implanted animal
»» x/y/z acceleration signals allow for postural information
»» total acceleration useful for validating events on EEG/EMG traces
(seizure, movement)
»» rapid acclimation: rats are not restrained in their activities
»» animal is freely moving: ideal alternative to tethered system
Key features
»» rodentPACK2 only weighs 4.4g with batteries - suitable for animals
50g and upwards
»» transmission range up to 5 m
»» 150 hours of continuous recording with same batteries
»» group housing with multiple animals in same cage
»» up to 32 animals in same room with no required shielding
»» only 1 receiver for 4 animals
»» fully digital: only 1 Ethernet cable per receiver handles data & power
»» rodentPACK2 may be fixed to the cranium or used as a transmitter
alone (jacket ECG for instance)
rodentPACK2 receiver
LAN

3. 3
CNS analysis software
Power spectrum analysis
The software allows the scientist to easily generate FFT power
spectrums with user defined frequency bands.
»» power in up to 6 adjustable frequency ranges
»» absolute and relative power values
»» versatile scheduling of analysis, epoch lengths, overlap factor,
windowing
Sleep scoring
Our high throughput, automated sleep scoring module differentiates
between four sleep stages and calculates global sleep scores.
»» define threshold values applicable to any parameter from any input
»» software applies logical rules to attribute 1 out of 4 sleep stages to
each epoch
»» trend graph displays parameters as well as sleep stages
»» adjust, on the fly, thresholds and see the effect on sleep scoring
Optional video for confirmation of sleep score and classification of
seizure type is also available.
Epilepsy seizure detection
The EEG analyzer module can also be used to detect epilepsy
seizures from EEG traces:
»» automatic software seizures detection is performed using
combined analysis of various parameters
»» all detected seizures are logged in a table
»» manual edition of seizures limits is possible
»» invalid seizures can be deleted
»» undetected seizures can be created
»» valid seizures can be exported to text file
*Concurrent ECG, hemodynamic, or pulmonary data analysis is also available.
EEG analyzer module within ecgAUTO software*
ecgAUTO 3-D display of average spectrums
over time
ecgAUTO epoch power spectrum (EEG analyzer)
4 epilepsy seizures detected
(EEG acquired with rodentPACK2)
ecgAUTO sleep scoring module. from top:
cortex, hippocampus, muscle, sleep score,
active wake, quiet wake, REM sleep, SW sleep

4. Neurobehavioral observations
emka TECHNOLOGIES’ integrated video capabilities facilitate behavioral
observations without the confounding effects of investigator interaction.
Our secured video data is embedded in our data files and can be linked
with other physiological signals, allowing the scientist to click on a change
in a physiological parameter and observe the associated behavior.
The system features adjustable image resolution, and infrared recording
for nighttime observations.
Link from telemetry implants to
emka TECHNOLOGIES software suite
»» reads signal from all DSI™ implants, including new HD models
»» ideal to extend existing telemetry setup or to upgrade old systems
»» records calibrated data in iox2, without the need of OpenART™ or
acquisition card in computer
»» contains its own ambient pressure transducer
»» up to 16 implant receivers and 8 analog inputs connect to a single
easyMATRIX
»» perfect synchronization of all signals from receivers or analog inputs
»» handles cases with 1, 2 or 4 receivers used for each subject
»» up to 4 easyMATRIX can be connected to a single computer
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