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History of Cell
  Discovery
Daily Question:
Brainstorm: What do you think of when you think of the
                       word cell?
            Use a circle map to brainstorm
History
*Cells were unknown until the
discovery of microscopes in the
1650’s
*two scientists working
independently built the first
microscopes
   *Anton von Leeuwenhoek in
   Holland
   *Robert Hooke in England
*Leeuwenhoek

*Studied pondwater, sour milk,
and other fluids
*named moving organisms
“animalcules”
scared people and caused a
sensation
Leeuwenhoek’s
drawings of
“animalcules” set off a
flurry of amateur and
sometimes ridiculous
claims, such as:

- pondwater
animalcules causing
madness!
*Hooke
*Studied cork - a kind
of tree bark
*named the structures
he saw “cells” because
they reminded him of
the small rooms
monks slept in.
Pause


Take two minutes to summarize your
notes into your own words.
*Spontaneous Generation

 From pre-historic times to about 1850,
 most people believed that under the right
 conditions,
 *living things could spontaneously
 appear from non-living material.
People throughout the
 Middle Ages believed
  that mice could be
        “created”
   spontaneously by
putting grain in dark,
quiet place and leaving
  it for a few weeks.
The discovery of
cells only confused
people more- If
cells are alive,
then where do
they come from?
                      Can these
                      almost invisible
                      things appear
                      spontaneously
                      from the air?
*Francesco Redi
  *Born 1626 in Italy
  *First to challenge
  the idea of
  spontaneous
  generation
  Did not accept the
  common belief that
  flies magically
  appeared from rotting
  meat
Redi’s Experiment
  IV=cover
  DV=presence of flies
  Hypothesis: If a jar
  containing rotting
  meat is covered, then
  it will produce no
  flies
Redi’s Conclusions
  Flies lay eggs, which
  grow into maggots,
  which metamorphose
  into flies
                             Fly eggs
  If flies can’t lay eggs,
  then no new flies can
  grow
Objections to Redi
Many people rejected Redi’s claim that
flies do not spontaneously generate
Their reasoning:
   “sealing the jar closed prevented a
   magical essence from entering the
   rotting meat and brining it to life”
   “Scientists seek only to challenge belief
   systems and stir things up”
Pause


Take two minutes to summarize your
notes into your own words.
*Lazzaro Spallanzani
 *1729. Italian
 *Believed microbes that spoil food
 come from the air and can be killed
 by boiling
 IV= air, DV=food spoilage
 Hypothesis: If air is allowed to
 reach food, then microbes will get in
 and cause it to spoil
Spallanzani’s Experiment

  Flask 1: boiled broth, open
  Flask 2: boiled broth, sealed shut
  Results
     Flask 1 spoiled
     Flask 2 did not spoil
Objections to Spallanzani

 Sealing the flask shut
 blocked the entrance of a
 magical life force in the air
 from getting to the broth.
 Since few people had seen
 these microbes, few people
 believed him.
*Louis Pasteur
*1822. France
Supported that
spontaneous
generation is a myth
*Invented
pasteurization
(sterilization by heat)
Pasteur’s Experiment
An improvement on Spallanzani’s work
Used special “swan-neck flasks” that allowed
air in but kept bacteria out
IV= bacteria, DV=spoiling broth
Hypothesis; If boiled broth is kept free of
bacteria, then it will not spoil even if air can
reach it.
The curved neck allows air in but traps
bacteria-carrying dust and dirt particles
*Spontaneous generation
is dead!
  Redi didn’t believe in it, and did an
  experiment using flies
  Spallanzani didn’t believe in it, and
  experimented with broth
  *Pasteur disproved it conclusively with
  his open-air yet spoilage free flasks.
Life from dead stuff= 0
Biogenesis = 3
  Experimental method wins out over
  superstition
  the cell theory takes hold among
  ordinary people
*Pasteur is the father of
modern microbiology
supported the last part of the cell theory:
cells only come from pre-existing cells
identified yeasts as the microbes that
change grape juice into wine
showed that heat can be used to sterilize
foods and preserve them in sealed glass
containers, and later cans.
Finally...
 in the late 1870’s,
 doctors start to wash
 their hands and
 instruments before
 operating...some even
 start wearing gloves!
 Joseph Lister’s wacky
 idea that antiseptics kill
 germs catches on...
The Cell Theory
The cell theory has three parts:
   All living things are composed of one
   or more cells
   Cells are the basic unit of structure
   and organization of all living things
   Cells can only come from pre-existing
   cells
*The cell theory
1.   *All living things contain at least one cell
        Many scientists working after Hooke
        and Leeuwenhoek observed different
        plants and animals
        Each of them noted that no matter
        what they observed, if it was alive it
        had cells.
2. *Cells are the smallest living units of
matter
  scientists quickly realized that when
  cells were dissected or broken open
  they died
  This meant that whatever “life” is, it
  is something that happens inside cells
*3. Cells can only come from pre-existing
cells
      does not answer the question of where
      the first cell came from or how it
      came to be.
      has not been disproved yet- no
      scientist has ever built a living cell
      from nonliving organic molecules
*The cell theory is one of
the most important theories
in biology.

 All living things contain at least one cell
 Cells are the smallest living units of matter
 Cells can only come from pre-existing cells
And now…
Use Google images (select
photos) to find photographs
of cells.
Write a description of three
cells that you see on your
paper…
Complete the
Study Guide for ch 7.1

If you finish early you may work on
credit Option A

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Cell discovery and theory

  • 1. History of Cell Discovery
  • 2. Daily Question: Brainstorm: What do you think of when you think of the word cell? Use a circle map to brainstorm
  • 3. History *Cells were unknown until the discovery of microscopes in the 1650’s *two scientists working independently built the first microscopes *Anton von Leeuwenhoek in Holland *Robert Hooke in England
  • 4. *Leeuwenhoek *Studied pondwater, sour milk, and other fluids *named moving organisms “animalcules” scared people and caused a sensation
  • 5. Leeuwenhoek’s drawings of “animalcules” set off a flurry of amateur and sometimes ridiculous claims, such as: - pondwater animalcules causing madness!
  • 6. *Hooke *Studied cork - a kind of tree bark *named the structures he saw “cells” because they reminded him of the small rooms monks slept in.
  • 7. Pause Take two minutes to summarize your notes into your own words.
  • 8. *Spontaneous Generation From pre-historic times to about 1850, most people believed that under the right conditions, *living things could spontaneously appear from non-living material.
  • 9. People throughout the Middle Ages believed that mice could be “created” spontaneously by putting grain in dark, quiet place and leaving it for a few weeks.
  • 10. The discovery of cells only confused people more- If cells are alive, then where do they come from? Can these almost invisible things appear spontaneously from the air?
  • 11. *Francesco Redi *Born 1626 in Italy *First to challenge the idea of spontaneous generation Did not accept the common belief that flies magically appeared from rotting meat
  • 12. Redi’s Experiment IV=cover DV=presence of flies Hypothesis: If a jar containing rotting meat is covered, then it will produce no flies
  • 13. Redi’s Conclusions Flies lay eggs, which grow into maggots, which metamorphose into flies Fly eggs If flies can’t lay eggs, then no new flies can grow
  • 14. Objections to Redi Many people rejected Redi’s claim that flies do not spontaneously generate Their reasoning: “sealing the jar closed prevented a magical essence from entering the rotting meat and brining it to life” “Scientists seek only to challenge belief systems and stir things up”
  • 15. Pause Take two minutes to summarize your notes into your own words.
  • 16. *Lazzaro Spallanzani *1729. Italian *Believed microbes that spoil food come from the air and can be killed by boiling IV= air, DV=food spoilage Hypothesis: If air is allowed to reach food, then microbes will get in and cause it to spoil
  • 17. Spallanzani’s Experiment Flask 1: boiled broth, open Flask 2: boiled broth, sealed shut Results Flask 1 spoiled Flask 2 did not spoil
  • 18. Objections to Spallanzani Sealing the flask shut blocked the entrance of a magical life force in the air from getting to the broth. Since few people had seen these microbes, few people believed him.
  • 19. *Louis Pasteur *1822. France Supported that spontaneous generation is a myth *Invented pasteurization (sterilization by heat)
  • 20. Pasteur’s Experiment An improvement on Spallanzani’s work Used special “swan-neck flasks” that allowed air in but kept bacteria out IV= bacteria, DV=spoiling broth Hypothesis; If boiled broth is kept free of bacteria, then it will not spoil even if air can reach it.
  • 21. The curved neck allows air in but traps bacteria-carrying dust and dirt particles
  • 22. *Spontaneous generation is dead! Redi didn’t believe in it, and did an experiment using flies Spallanzani didn’t believe in it, and experimented with broth *Pasteur disproved it conclusively with his open-air yet spoilage free flasks.
  • 23. Life from dead stuff= 0 Biogenesis = 3 Experimental method wins out over superstition the cell theory takes hold among ordinary people
  • 24. *Pasteur is the father of modern microbiology supported the last part of the cell theory: cells only come from pre-existing cells identified yeasts as the microbes that change grape juice into wine showed that heat can be used to sterilize foods and preserve them in sealed glass containers, and later cans.
  • 25. Finally... in the late 1870’s, doctors start to wash their hands and instruments before operating...some even start wearing gloves! Joseph Lister’s wacky idea that antiseptics kill germs catches on...
  • 26. The Cell Theory The cell theory has three parts: All living things are composed of one or more cells Cells are the basic unit of structure and organization of all living things Cells can only come from pre-existing cells
  • 27. *The cell theory 1. *All living things contain at least one cell Many scientists working after Hooke and Leeuwenhoek observed different plants and animals Each of them noted that no matter what they observed, if it was alive it had cells.
  • 28. 2. *Cells are the smallest living units of matter scientists quickly realized that when cells were dissected or broken open they died This meant that whatever “life” is, it is something that happens inside cells
  • 29. *3. Cells can only come from pre-existing cells does not answer the question of where the first cell came from or how it came to be. has not been disproved yet- no scientist has ever built a living cell from nonliving organic molecules
  • 30. *The cell theory is one of the most important theories in biology. All living things contain at least one cell Cells are the smallest living units of matter Cells can only come from pre-existing cells
  • 31. And now… Use Google images (select photos) to find photographs of cells. Write a description of three cells that you see on your paper…
  • 32. Complete the Study Guide for ch 7.1 If you finish early you may work on credit Option A