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L.Rademacher et al., 2010 Neuroimage

Dissociation of neural networks for anticipation
              and consumption of
          monetary and social reward


                                                       Anna Jo
                                                   May 4th, 2010
Introduction

                                                       Reward Anticipation
                  Reward
                Processing                            Reward Consumption



    Money               Social Approval




                                                      Ventral Striatum(NAcc):
                                                     Reward-related Brain area
                                                     “the universal mediator of
                                                         reward prediction”




Aim: To provide evidence for dissociable neural networks involved in reward anticipation and
reward consumption
Experimental Procedure
                      Stimuli and task                             Image analysis



1.    Participants: 32 subjects (13 men)
2.    88 trials/task X 2(MID, SID) = 176 trials


         MID                          SID

     No Outcome                   No Outcome

                                 Happy closed
      0.2 Euros                     mouth
                                  Happy open
      1.0 Euros                     mouth
                                Happy open
      3.0 Euros
                               mouth exuberant


                                                  “Monetary Incentive         “Social Incentive
                                                   Delay”(MID) task           Delay”(SID) task
                                                  Knutson et al.(2000)         Spreckelmeyer
                                                                                et al.(2000)
Experimental Procedure
      Stimuli and task                       Image analysis

                                       Anticipation vs. Consumption
     Contrasts
                                                       MID
                             Anticipation         Anticipated           Anticipated
                               phase             “hit outcome”         “no outcome”
Contrast-specific ROI        Consumption             Gained               Gained
                                phase            “hit outcome”         “no outcome”

                                                       SID

   Signal Change         1       Anticipation hit outcome > Anticipation no outcome

                         2      Consumption hit outcome > Consumption no outcome
   2 tasks(MID, SID)
                         3       Anticipation hit outcome > Consumption hit outcome
            X
    4 reward levels
                         4       Consumption hit outcome > Anticipation hit outcome
(no potential outcome,
  Low, Medium, High)
                         5   Consumption MID hit outcome > Consumption SID hit outcome
            X
        22 trials
                         5   Consumption SID hit outcome > Consumption MID hit outcome
Results
                  Behavioral Results                                   Neuroimaging Results


                                        Reaction times
     “tasks”(monetary, social) and “incentive magnitude”(no outcome, low, medium, high)


                                                     1   MID [219 ms(SE=5.98)] vs. SID [232 ms(SE=5.38)]

                                                         Linearly decreased with increasing levels of potential
                                                     2
                                                               reward in both tasks (F(3,25)=6.29, p=0.002)

                                                           Significantly faster reaction times for all levels of
                                                     3
                                                                reward compared to ‘no outcome’ condition

                                                         Faster reaction times to the highest level of potential
                                                     4       reward compared to the lowest level of potential

Circles with one, two, and three bars announce                               reward (all p<0.05)
increasing levels of potential reward, triangles
represent “no outcome.” Error bars indicate the            “task” and “incentive magnitude” did not interact
standard error of the mean (s.e.m.).                 5
                                                                                   (p>0.05)
Results
                   Behavioral Results                                     Neuroimaging Results

     Reward Anticipation


                                                            1    Anticipation hit outcome > Anticipation no outcome
                                                                => bilateral activation of the putamen, caudatus
                                                                and NACC


                                                            3   Anticipation hit outcome > Consumption hit outcome

                                                                => Ventral Striatum for both tasks




- Activation foci during MID (left) and SID (right) “hit
outcome” anticipation compared to “no outcome”
anticipation masked by the respective contrast (“hit
outcome”anticipation > ”hit outcome” consumption)
(p < 0.001, uncorrected; y=9).
- A conjunction analysis between the two tasks (MID, SID)
was performed and the resulted peak activation
appearing in the left ventral striatum (NAcc)
Results
                     Behavioral Results                                        Neuroimaging Results

     Reward Consumption

                                                          5     Consumption MID hit outcome > Consumption SID hit outcome

                                                              => Thalamus activation for monetary reward consumption

                                                          4          Consumption hit outcome > Anticipation hit outcome

                                                              => Thalamus activation for MID task
                                                              => A linear increase of activations with higher levels of reward
Activation focus during MID consumption compared to           independent of incentive type
“no outcome” masked by the contrast (MID “hit outcome”
consumption > MID “hit outcome” anticipation) (p<0.001)

                                                          5     Consumption SID hit outcome > Consumption MID hit outcome

                                                              => Bilateral Amygdala activation for social reward consumption

                                                          4          Consumption hit outcome > Anticipation hit outcome
                                                              => Amygdala recruitment for SID task
                                                              => A significant main effect of incentive magnitude in response
Activation foci during SID consumption compared to “no        to reward compared to “no outcome”, independent of incentive
outcome” masked by the contrast (SID “hit outcome”            type
consumption > SID “hit outcome” anticipation) (p<0.001)
Discussion
                    Interpretation                                                   Summary


1.   Ventral striatal structures were not found activated during the consumption phase
2.   Prefrontal activation is specifically related to monitoring of unwanted outcomes (Dillon et al., 2008).
3.   The thalamic activation observed in current experiment may reflect a reward value prediction process.
     => The thalamus: an important function in goal-directed behaviour through ranking of incentive value.
4.   While the amygdala was strongly activated in response to socially rewarding pictures, the activation evoked by
     monetary stimuli was much weaker. => amygdala is also associated with the processing of facial expressions

     Presentation of Monetary Rewards                                                     Social Stimuli
                 Thalamus                                                             Amygdalae activation

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Dissociation of neural networks for anticipation and consumption

  • 1. L.Rademacher et al., 2010 Neuroimage Dissociation of neural networks for anticipation and consumption of monetary and social reward Anna Jo May 4th, 2010
  • 2. Introduction Reward Anticipation Reward Processing Reward Consumption Money Social Approval Ventral Striatum(NAcc): Reward-related Brain area “the universal mediator of reward prediction” Aim: To provide evidence for dissociable neural networks involved in reward anticipation and reward consumption
  • 3. Experimental Procedure Stimuli and task Image analysis 1. Participants: 32 subjects (13 men) 2. 88 trials/task X 2(MID, SID) = 176 trials MID SID No Outcome No Outcome Happy closed 0.2 Euros mouth Happy open 1.0 Euros mouth Happy open 3.0 Euros mouth exuberant “Monetary Incentive “Social Incentive Delay”(MID) task Delay”(SID) task Knutson et al.(2000) Spreckelmeyer et al.(2000)
  • 4. Experimental Procedure Stimuli and task Image analysis Anticipation vs. Consumption Contrasts MID Anticipation Anticipated Anticipated phase “hit outcome” “no outcome” Contrast-specific ROI Consumption Gained Gained phase “hit outcome” “no outcome” SID Signal Change 1 Anticipation hit outcome > Anticipation no outcome 2 Consumption hit outcome > Consumption no outcome 2 tasks(MID, SID) 3 Anticipation hit outcome > Consumption hit outcome X 4 reward levels 4 Consumption hit outcome > Anticipation hit outcome (no potential outcome, Low, Medium, High) 5 Consumption MID hit outcome > Consumption SID hit outcome X 22 trials 5 Consumption SID hit outcome > Consumption MID hit outcome
  • 5. Results Behavioral Results Neuroimaging Results Reaction times “tasks”(monetary, social) and “incentive magnitude”(no outcome, low, medium, high) 1 MID [219 ms(SE=5.98)] vs. SID [232 ms(SE=5.38)] Linearly decreased with increasing levels of potential 2 reward in both tasks (F(3,25)=6.29, p=0.002) Significantly faster reaction times for all levels of 3 reward compared to ‘no outcome’ condition Faster reaction times to the highest level of potential 4 reward compared to the lowest level of potential Circles with one, two, and three bars announce reward (all p<0.05) increasing levels of potential reward, triangles represent “no outcome.” Error bars indicate the “task” and “incentive magnitude” did not interact standard error of the mean (s.e.m.). 5 (p>0.05)
  • 6. Results Behavioral Results Neuroimaging Results Reward Anticipation 1 Anticipation hit outcome > Anticipation no outcome => bilateral activation of the putamen, caudatus and NACC 3 Anticipation hit outcome > Consumption hit outcome => Ventral Striatum for both tasks - Activation foci during MID (left) and SID (right) “hit outcome” anticipation compared to “no outcome” anticipation masked by the respective contrast (“hit outcome”anticipation > ”hit outcome” consumption) (p < 0.001, uncorrected; y=9). - A conjunction analysis between the two tasks (MID, SID) was performed and the resulted peak activation appearing in the left ventral striatum (NAcc)
  • 7. Results Behavioral Results Neuroimaging Results Reward Consumption 5 Consumption MID hit outcome > Consumption SID hit outcome => Thalamus activation for monetary reward consumption 4 Consumption hit outcome > Anticipation hit outcome => Thalamus activation for MID task => A linear increase of activations with higher levels of reward Activation focus during MID consumption compared to independent of incentive type “no outcome” masked by the contrast (MID “hit outcome” consumption > MID “hit outcome” anticipation) (p<0.001) 5 Consumption SID hit outcome > Consumption MID hit outcome => Bilateral Amygdala activation for social reward consumption 4 Consumption hit outcome > Anticipation hit outcome => Amygdala recruitment for SID task => A significant main effect of incentive magnitude in response Activation foci during SID consumption compared to “no to reward compared to “no outcome”, independent of incentive outcome” masked by the contrast (SID “hit outcome” type consumption > SID “hit outcome” anticipation) (p<0.001)
  • 8. Discussion Interpretation Summary 1. Ventral striatal structures were not found activated during the consumption phase 2. Prefrontal activation is specifically related to monitoring of unwanted outcomes (Dillon et al., 2008). 3. The thalamic activation observed in current experiment may reflect a reward value prediction process. => The thalamus: an important function in goal-directed behaviour through ranking of incentive value. 4. While the amygdala was strongly activated in response to socially rewarding pictures, the activation evoked by monetary stimuli was much weaker. => amygdala is also associated with the processing of facial expressions Presentation of Monetary Rewards Social Stimuli Thalamus Amygdalae activation