Dissociation of neural networks for anticipation and consumption
1. L.Rademacher et al., 2010 Neuroimage
Dissociation of neural networks for anticipation
and consumption of
monetary and social reward
Anna Jo
May 4th, 2010
2. Introduction
Reward Anticipation
Reward
Processing Reward Consumption
Money Social Approval
Ventral Striatum(NAcc):
Reward-related Brain area
“the universal mediator of
reward prediction”
Aim: To provide evidence for dissociable neural networks involved in reward anticipation and
reward consumption
3. Experimental Procedure
Stimuli and task Image analysis
1. Participants: 32 subjects (13 men)
2. 88 trials/task X 2(MID, SID) = 176 trials
MID SID
No Outcome No Outcome
Happy closed
0.2 Euros mouth
Happy open
1.0 Euros mouth
Happy open
3.0 Euros
mouth exuberant
“Monetary Incentive “Social Incentive
Delay”(MID) task Delay”(SID) task
Knutson et al.(2000) Spreckelmeyer
et al.(2000)
4. Experimental Procedure
Stimuli and task Image analysis
Anticipation vs. Consumption
Contrasts
MID
Anticipation Anticipated Anticipated
phase “hit outcome” “no outcome”
Contrast-specific ROI Consumption Gained Gained
phase “hit outcome” “no outcome”
SID
Signal Change 1 Anticipation hit outcome > Anticipation no outcome
2 Consumption hit outcome > Consumption no outcome
2 tasks(MID, SID)
3 Anticipation hit outcome > Consumption hit outcome
X
4 reward levels
4 Consumption hit outcome > Anticipation hit outcome
(no potential outcome,
Low, Medium, High)
5 Consumption MID hit outcome > Consumption SID hit outcome
X
22 trials
5 Consumption SID hit outcome > Consumption MID hit outcome
5. Results
Behavioral Results Neuroimaging Results
Reaction times
“tasks”(monetary, social) and “incentive magnitude”(no outcome, low, medium, high)
1 MID [219 ms(SE=5.98)] vs. SID [232 ms(SE=5.38)]
Linearly decreased with increasing levels of potential
2
reward in both tasks (F(3,25)=6.29, p=0.002)
Significantly faster reaction times for all levels of
3
reward compared to ‘no outcome’ condition
Faster reaction times to the highest level of potential
4 reward compared to the lowest level of potential
Circles with one, two, and three bars announce reward (all p<0.05)
increasing levels of potential reward, triangles
represent “no outcome.” Error bars indicate the “task” and “incentive magnitude” did not interact
standard error of the mean (s.e.m.). 5
(p>0.05)
6. Results
Behavioral Results Neuroimaging Results
Reward Anticipation
1 Anticipation hit outcome > Anticipation no outcome
=> bilateral activation of the putamen, caudatus
and NACC
3 Anticipation hit outcome > Consumption hit outcome
=> Ventral Striatum for both tasks
- Activation foci during MID (left) and SID (right) “hit
outcome” anticipation compared to “no outcome”
anticipation masked by the respective contrast (“hit
outcome”anticipation > ”hit outcome” consumption)
(p < 0.001, uncorrected; y=9).
- A conjunction analysis between the two tasks (MID, SID)
was performed and the resulted peak activation
appearing in the left ventral striatum (NAcc)
7. Results
Behavioral Results Neuroimaging Results
Reward Consumption
5 Consumption MID hit outcome > Consumption SID hit outcome
=> Thalamus activation for monetary reward consumption
4 Consumption hit outcome > Anticipation hit outcome
=> Thalamus activation for MID task
=> A linear increase of activations with higher levels of reward
Activation focus during MID consumption compared to independent of incentive type
“no outcome” masked by the contrast (MID “hit outcome”
consumption > MID “hit outcome” anticipation) (p<0.001)
5 Consumption SID hit outcome > Consumption MID hit outcome
=> Bilateral Amygdala activation for social reward consumption
4 Consumption hit outcome > Anticipation hit outcome
=> Amygdala recruitment for SID task
=> A significant main effect of incentive magnitude in response
Activation foci during SID consumption compared to “no to reward compared to “no outcome”, independent of incentive
outcome” masked by the contrast (SID “hit outcome” type
consumption > SID “hit outcome” anticipation) (p<0.001)
8. Discussion
Interpretation Summary
1. Ventral striatal structures were not found activated during the consumption phase
2. Prefrontal activation is specifically related to monitoring of unwanted outcomes (Dillon et al., 2008).
3. The thalamic activation observed in current experiment may reflect a reward value prediction process.
=> The thalamus: an important function in goal-directed behaviour through ranking of incentive value.
4. While the amygdala was strongly activated in response to socially rewarding pictures, the activation evoked by
monetary stimuli was much weaker. => amygdala is also associated with the processing of facial expressions
Presentation of Monetary Rewards Social Stimuli
Thalamus Amygdalae activation