Exact Sciences CEO Kevin Conroy delivered a keynote on the need for growth in Wisconsin's tech sector at the 2015 Forward Festival August 24, 2015.

1. v
The Need for Growth in
Wisconsin’s Tech Sector
Forward Fest
August 25, 2015

2. Exact Sciences progress since 2013
Five keys to changing Wisconsin’s economy
Importance of entrepreneurship in Wisconsin
2
Forward Fest 2015
Why the success of Wisconsin’s tech industry is critical

3. Cologuard®
: The Foundation to Our Success
3

4. Aug Sep Oct Nov Dec Jan Feb Mar Apr May Jun
Physicians Ordering Cologuard® is Rapidly Expanding
14,700 ordering physicians
Adding ~500 new physicians weekly
14Source: Exact Sciences Laboratories LLC data (unpublished)

5. Cologuard’s® Strong Demand and Launch Trajectory
4K
11K
21K
>32K
Q4 Q1 Q2 Q3
5
Completed Cologuard Tests
Guidance
Source: Exact Sciences Laboratories LLC data (unpublished)

6. Never screened
before
Screened with
colonscopy only
Screened with
colonscopy and
FIT/FOBT
Screened with
FIT/FOBT only
36%36%
Source: Exact Sciences Laboratories LLC data (unpublished), n = 2,997
8%20%
6
Screening History of Cologuard® Users
Increasing America’s screening population

7. 7
Building a Team with High-Quality Talent
3 35
61 87
102
409
682
2009 2010 2011 2012 2013 2014 2015
Exact Sciences personnel growth: 2009 through Today

8. 8
Developing a World-Class Lab
Capable of processing more than 1 million Cologuard® tests per year

9. 9
Committing to Growing in Madison

10. 10Source: Exact Sciences Data
Innovation Requires Investment
Nine financings raised more than $685 million
$8.2 M
$18.9 M
$69.0 M
$28.8 M
$61.2 M
$78.1 M
$146.6 M
$100.0 M
$175.0 M
Jun-09 Apr-10 Nov-10 Dec-11 Aug-12 Jun-13 Apr-14 Dec-14 Jul-15

11. Pancreatic Esophageal Lung
Developing a Pipeline of Tests to Detect Cancer Early
Combined:
270,000
US deaths
per year

12. 12
Remaining Committed to Wisconsin

13. 13
Entrepreneurs Really Matter to Wisconsin

14. 14
Source: U.S. Census Bureau,
2010-2030 5-Year American
Community Survey Estimation
Aging Population and Workforce
2010 2011 2012 2013 2015 2020 2025 2030
20 - 44
45 - 64
65+
Projecting Wisconsin Population by Age

15. 15
Wisconsin’s Shrinking Middle Class
Median household income falling
$56,208
2005 2013
$51,467
Source: U.S. Census Bureau Data

16. 16
New Firms are the Largest Drivers of Job Creation
Source: Kaufman Foundation

17. 17
Startups Create More Jobs than All Other Companies

18. 18Source: U.S. Census Bureau; fivethirtyeight.com
But the Share of New Businesses has Declined
Startups as a percentage of total

19. Wisconsin’s Ranking for Startup Activity
Only 100 new ventures per
100,000 residents
50thKauffman Foundation
2015 Ranking
19Source: Kaufman Foundation

20. 20
Wisconsin Minnesota
Population 5.7M 5.4M
Per capita income (2013) $51,467 $59,836
Gross state production (GSP) $293B $326B
Budget surplus/deficit (projected) - $233M* $1.9B
Percentage of college graduates 25% 31%
Venture capital funding (2013) $34M $270M
Source: www.stats.indiana.edu

21. 21Source: MoneyTree; PWC
Venture Capital Investment (2010 – 2015)
Minnesota outpaced Wisconsin by more than 3X
Wisconsin Minnesota
$396 million
$1.4 billion

22. Ideas for Wisconsin’s Long-Term Growth
Education
Raise standards, more apprenticeship
programs, focus on entrepreneurship
Collaboration
Improve connectivity among startups ;
Renew 2000-2003 UW Economic Summit
Change industry mix
Focus public policy on growth industries:
information systems, health care, life sciences
Capital formation
Attract more venture capital, angel investors,
banks and early-stage financing
Accountability
Hold UW System and WARF accountable for
startup formation
22

23. 23
Five Keys to Changing Wisconsin’s Economy
Talent
Collaboration
Innovation
Capital
Entrepreneurship