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Reduction Of Conjunctival Bacterial Flora With The Use Of Mupirocin Nasal Ointment Terry J. Alexandrou, MD Ophthalmology Resident  The University of Chicago School of Medicine Department of Ophthalmology and Visual Science
Acknowledgements ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Post-Cataract Surgery Endophthalmitis  ,[object Object],[object Object],Han DP, et al.  Am J Ophthalmol.  1996;122(1):1-17.  Endophthalmitis Vitrectomy Study 24% 70% 6% Gram-positive coagulase-negative organisms ( Staphylococcus epidermidis)   Gram-negative organisms  Other Gram-positive organisms
Sources of Bacterial Contamination  ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Mupirocin (Bactroban ® , Glaxo-Smith Kline)  ,[object Object],[object Object],[object Object],[object Object],Mupirocin (Bactroban®) Ointment (C 26 H 43 O9) 2 Ca●2H20
Reduction of Surgical Site Infections Effectiveness of using Mupirocin:  Non-Ophthalmic Literature ,[object Object],[object Object],[object Object],[object Object]
Reduction of Surgical Site Infections Effectiveness of using Mupirocin ,[object Object]
Methods  ,[object Object],[object Object],[object Object],[object Object],A)  B)  C)
Methods Cultures   & Microbiology ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Results  Nasal Cultures 100% Positive 9%  S. Aureus  (3 MRSA / 3 MSSA)  16%  S. viridans   22%  Corynebacterium   8% Others 45% Coag. Neg.  Staph
Results  Conjunctival Cultures
Discussion   ,[object Object],[object Object]
Discussion   ,[object Object],[object Object],[object Object],* Nagle F, Cooper RL. Nasal secretions in ocular surgery under general and local anesthesia.  Ophthalmic Surg  1993;24:13-15.
Conclusions ,[object Object],[object Object],[object Object],[object Object]
Thank you for your attention

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Reduction of Conjunctival Bacterial Flora with the Use of Mupirocin Nasal Ointment

  • 1. Reduction Of Conjunctival Bacterial Flora With The Use Of Mupirocin Nasal Ointment Terry J. Alexandrou, MD Ophthalmology Resident The University of Chicago School of Medicine Department of Ophthalmology and Visual Science
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  • 10. Results Nasal Cultures 100% Positive 9% S. Aureus (3 MRSA / 3 MSSA) 16% S. viridans 22% Corynebacterium 8% Others 45% Coag. Neg. Staph
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  • 15. Thank you for your attention