Originally part of a presentation: Detection of a single BSA molecule by amplifying its Raman signal. Done with my friend: Pemba Lama [I came up with the idea for amplifier (and detector scheme) so that is what I have posted] For Course Project: Nano and Micro Photonics Under Prof. Vinod Menon, Queens College and Graduate Center, CUNY The project was devised so that students come up with original ideas, based on known physical principles, for the detection of a single molecule of BSA (a biological molecule). Unfortunately, this means we could not verify the validity of the work, and my work is no exception. It is my hope that I have not overlooked any relevant physical principles, and that this kind of amplifier is possible. If anyone finds my design promising then: -I would certainly like to know the simulation and experimental results -I would like credit in the resulting publication – Thanks. The substrate work that I did prior to this (and the mis-conceived SPASER work that I previously came up with) is here: http://www.slideshare.net/faissal.bd/spaser-amplifierforsmallsignaldetectionforramanscatteringmeasurementsofasinglemoleculeofbsa The SPASER work there is fundamentally flawed, but perhaps the substrate work is not entirely useless.

1. SPASER Amplifier Design for Small Signal (Raman Scattering) Detection from a Single Molecule (of BSA) Faisal Halim The City College of New York, CUNY Thursday, 13 th May, 2010 Originally part of: Detection of a single BSA molecule by amplifying its raman signal. Done with my friend: Pemba Lama [I have removed Pemba’s slides from this presentation as I have not asked for his permission to post them] [I came up with the idea for amplifier (and detector scheme) so that is what I have posted] For Course Project: Nano and Micro Photonics Prof. Vinod Menon, Queens College and Graduate Center, CUNY

2. Raman Setup Excitation Laser SERS Substrate Substrate Movable Relative to Excitation and Detector Heads BSA Molecule Raman Scattered Spectrum Raman Scattering Detector

4. Raman Signal Amplifier SPASER Metamaterial Crystal Side View Front View Metamaterial SPASER Emitter SPASER Emitters for a given Wavelength SPASER Elements are arranged to intercept and amplify any incoming photon at any Wavelength Fluorescent Dye Gain Medium

6. Signal Detection Schematics (Conceptual) Shorter Wavelength gets reflected PMT or APD PMT or APD PMT or APD PMT – Photomultiplier Tube APD – Avalanche Photo Diode Dichroic Mirror