Fitgenes presentation on Genome-based Healthcare for the Workplace

1. Improving Health, Performance and Productivity
Personalised Genome-based Healthcare in the Workplace
Dr Paul Beaver - Director (Science), Co-founder

2. The Current Health Crisis
There are 3 trends that significantly
influence workplace health and
performance.
Influencing Workplace Health and Performance

3. Recent Australian Government data shows
1
1) Life Expectancy:
Increasing but Health Expectancy decreasing.
Men - last 18.6 years and women - last 20.7 years with disabilities.
2) Obesity Epidemic:
Australians overweight or obese
68% of men (over 7.3 million ) & 55% of women (over 6.0 million)
3) Ageing Population:
Baby Boomers
By 2020 approximately 20% of Australians will be over 65 years old
1 References available on request
The Current Health Crisis
Influencing Workplace Health and Performance

4. 1. Stress
2. Exercise- lack of
3. Food- quantity & quality
4. Smoking
5. Alcohol / drugs
6. Environmental factors- air, water
NOW the most important factor is:
7. Interaction of our genes with our lifestyle choices
Factors Contributing to Current Health Crisis

5. Importance of Gene and
Environment/Lifestyle Interactions
The recent Federal Government report released in May 2009, titled
“Weighing it up – Obesity in Australia”, stated that:
1.Environmental and Lifestyle Factors
contribute about 30% to an individual‟s body weight, and;
2. Genetics contributes the other 70%
(Similarly, research indicates the ratio for Heart Health is approx. 50 % and 50%.)

6. Personalised Genome-based Healthcare

7. Genetics in the Workplace*
Major technological advances in the last few decades have increased
our knowledge of the role that genetics plays in occupational diseases
Combined with knowledge of other factors that contribute to
occupational morbidity and mortality, genetic information will play an
increasing role in preventing occupational disease.
Understanding the role of genetic factors and their interaction with
environmental/occupational exposures is important in occupational
health and could lead to further prevention and control efforts, the
identification of novel therapeutic targets and educational strategies for
better management of work-related diseases.
*Recent On-line article from the Centers for Disease Control and Prevention
-National Institute for Occupational Health and Safety
,USA, http://www.cdc.gov/niosh/topics/genetics/ ,

8. Genetics in the Workplace
“In summary, the use of genetic
information in the workplace has the
potential to affect every worker in the
United States.”
*Genetics in the Workplace - Implications for Occupational Safety and Health,
DEPARTMENT OF HEALTH AND HUMAN SERVICES, Centers for Disease Control and Prevention National
Institute for Occupational Safety and Health, NIOSH, 2010

9. Nutrigenetics and Nutrigenomics
Nutrigenetics
Nutrigenomics

10. Nutrigenomics – What is it?
Studies the interaction between our genes, diet and
lifestyle choices.
It‟s true you can’t change your genes, HOWEVER,
you can compensate for their influence by making
the right nutritional, exercise and lifestyle choices.
Nutrigenomics+ =

11. The Fitgenes „Multi-disciplinary‟
Convergence Approach
Exercise &
Movement
Behavioural
& Lifestyle
Choices
Genetic Factors
Nutrition

12. CA Support Announced:
“Healthy Solutions Win Backing”
On 29 June 2012, Commercialisation Australia (CA) announced
another $9 million in funding to support 24 new participants and
extend additional funds to two existing participants on the
program.

13. Commercialisation Australia

14. Where to From Here?

15. Our Vision
To help people maximise their potential
for
Healthy Living – Healthy Ageing©

16. > Disease
> Symptoms
Birth Death
Personalised, Strategic and Targeted
Interventions
> Improve health expectancy and live disease
free.
> Maximise health potential:
 Genetic predispositions
 Nutrition
 Exercise
 Lifestyle Choices
 Stress Management
HealthExpectancy
LifeExpectancy
Goal: Avoid Poor Health:

17. But how?

18. The Fitgenes Philosophy
Tr
Genotype
& Cell
Function
Gene Expression
Maximise your Potential for
Healthy Living - Healthy Ageing
5) Optimise
metabolism
7) Burn fat 1)Reduce
Inflammation
6) Remove toxins
(detox)
3) Improve
circulation
4) Healthy nutrition
2) Redox
Balance
Cell Health

19. Why Inflammation is the #1 Focus

20. 15 Risk Factors for Heart Health
1. Genetic factors
2. Diabetes
3. Smoking
4. Hypertension
5. Lack of exercise
6. Depression/Lack of optimistic thinking
7. Obesity
8. Stress
9. Elevated cholesterol, triglycerides
10.Elevated Homocysteine
11.Lack of faith
12.Inadequate intake of fruits and
vegetables
13.C-Reactive Protein
14.Hypothyroid
15.Inadequate Omega-3

21. 15 Risk Factors for Heart Health
1. Genetic factors ↑CRP
2. Diabetes ↑CRP
3. Smoking ↑CRP
4. Hypertension ↑CRP
5. Lack of exercise ↑CRP
6. Depression/Lack of optimistic
thinking ↑CRP
7. Obesity ↑CRP
8. Stress ↑CRP
9. Elevated cholesterol, triglycerides ↑CRP
10.Elevated Homocysteine ↑CRP
11.Lack of faith ↑CRP
12.Inadequate intake of fruits and
vegetables ↑CRP
13.C-Reactive Protein ↑CRP
14.Hypothyroid ↑CRP
15.Inadequate Omega-3 ↑CRP

22. TNFα
IL-6
↑ CRP
Atherogenic Insulin-
Resistant “Dysmetabolic
Milieu”
↑ Risk of Coronary
Syndrome
Adipose
Tissue
CRP = C-reactive protein; IL-6 = interleukin 6; TNFα = tumor necrosis factor alpha
Adapted from Després JP. Int J Obes Relat Metab Disord.2003;27:S22-S24,
?

25. Personal
Genetic
Profile
Health Destiny
(Health Potential + Pre-disposition to Risk)
Nutrition, Exercise &
Lifestyle Assessment
Investigate
Medical
Biomarkers
Health Pre-disposition
(identify potential for
health or risk)
Family History
Recommend Personalised Gene-matched
Nutrition, Exercise and Lifestyle
Interventions
Fitgenes Health Program - Overview

26. Fitgenes 12 Week Program Outline
Program Item Baseline
Data
Collection
Week
1
Week
4
Week
8
Week
12
Week
16
Next Phase
of
Treatment
DNA Profile Yes
Pathology Tests
(Panel Options)
Yes Retest
pathology
Initial
Questionnaire
Yes
Review
Questionnaire
Yes
Treatment Plan and
Protocol
Yes
In-clinic
anthropometric
tests
Yes Yes Yes Yes
Program Summary
Report
Yes
Clinic Appointment Yes
30 min
Yes
60 min
Yes
30 min
Yes
30 min
Yes
30 min
Yes
30
min

27. Weight Loss Case
Study: “Jenny”
Practitioner - Sharon Palmer

28. > 6 years ago weighed 140 kgs.
> Has had significant weight loss in the past:
- Lost 60 kg: regained
- Lost 50 kg: regained
> Went to GP for weight loss:
- Put onto Optifast Shakes:
- 3 shakes per day
- No food at all for 10 months
> GP also put on drugs to increase metabolism and suppress appetite:
- Use for 3 months but couldn‟t tolerate.
- Caused anxiety and panic attacks.
- Had also used T3, but also stopped this as didn‟t like the effect.
Jenny‟s Weight Loss History

29. Jenny‟s Rebound Weight Gain
> When stopped the Optifast shakes went back to being careful with
diet.
> Regained 5 kgs per week, and ended back at starting weight.
> Was so unhappy she „wanted to die‟.
– GP recommended a gastric bypass but Jenny didn‟t want this.
– Decided to have a gastric sleeve. Done Feb 2007.
– Initially lost a lot of weight.
– Weight loss has now stopped and Jenny is beginning to gain
weight again.
– She is afraid she will gain all her weight back again.

30. Jenny DNA Fat Metabolism

31. Jenny‟s Data
Follow up Follow up
Date 14/9/11 16/1/12 8/3/12
Patient Actual Age
Biological Age
48
61.54 H
48
51.63 H
48
46.73
Lost 14.81 yrs
First time younger than
actual age
Weight kg 85 kg 72 kg
-13 kg total
Never been this weight
73.5 kg
Fat Mass:
Difference from ideal
35.14 kg
+15.43
24.93 kg
+2.23 kg
Total loss
-10.21kg
23.85
-1.08
Total loss
-11.29kg
Muscle Mass:
Difference from ideal
21.78 kg
-4.97 kg
21.38 kg
-0.04 kg
Total loss -0.40kg
23.85
+2.47
Total gain
+2.07
IntraCellular Fluid %
(Aim 50-60%)
42.02 L 45.72 L 48.23L
ExtraCellular Fluid %
(Aim 40-50%)
57.98 H 54.28 H 51.77 H
Cellular Fluid Balance:
(Ideal -20 to 0)
36.30 H 26.27 H
Best reading
17.06
Best reading
Waist (cm)
Aim F <80 M <94
95 74
Total loss of 21 cm
72
Total loss of 23 cm
Inflammation decreasing Inflammation
decreasing

32. .
“Doing my Fitgenes DNA
profile has helped me gain
information that has helped
me on a number of levels.”
Jenny B. 2012
Firstly, I felt better about my previous
struggles, knowing there was an
underlying genetic reason for my obesity
and yo-yo weight gains. I felt better about
the fact that it had a root cause. I suppose
I could have felt powerless to do much
about it but instead it energised me to
fight against it. …..

33. Testimonial February 2012
› Doing my Fitgenes DNA profile has helped me gain information that has helped me on a number of
levels.
› Firstly, I felt better about my previous struggles, knowing there was an underlying genetic reason for
my obesity and yoyo weight gains. I felt better about the fact that it had a root cause. I suppose I
could have felt powerless to do much about it but instead it energised me to fight against it. I am
actually proud of myself for losing weight. My genetic profile would indicate this is very difficult for me,
and I am prone to rebound weight gain.
› It also encourages me to fight harder to not allow myself to regain. I don‟t think I can get away with
things anymore. Also, there was always a point in the past when I assumed I could eat normally. Now I
have much more information and it enables me to talk straight to myself.
› In food terms it has changed my whole way of eating. I found that I cannot tolerate a high intake of
saturated fats and my body is designed to store these. As a result, I do not generally eat meat or
animal fats like hard cheese. I love cheese and wine, I just don‟t eat the cheese any more. (I am still
working on the wine). It makes it much easier to maintain my weight loss. There are times when I do
eat them but very rarely. The point is I can now make an informed choice.
› Overall, I would say that this is the best decision I have made as it has given me information that has
helped me make sense of my struggles and gives me tools to make decisions for the future. I just can‟t
kid myself anymore as I know the truth!!!

34. Case Studies – High Blood Pressure
Client: A B C D
Age (years) 50 34 50 54
Gender Male Male Male Male
FT Program Start Date 24/02/2012 5/11/2011 23/11/2011 16/04/2010
FT Program Week # 1 5 1 9 1 12 1 6
Blood Pressure (BP) 155/99 1 130/85 130/80 2 120/65 183/84 3 117/77 190/110 140/80
Weight (Wt) Kg 106 101 124 108 - 4 - 82 76
Change in Wt 5 14 6
Waist Circumf. (WC) cm 119 114 111 98 - - - -
5 13
Notes:
1. BP had been at 172/119 before starting the program
2. BP had been at 158/100 before starting the program
3. BP had been at 213/110 before starting the program
4 Weight Management was not a health goal for this client as his % body fat was in the superfit range

35. Pracware

36. In Conclusion…
Personalised, genome-based
healthcare has an important role
to play in improving workplace:
> Health
> Performance
> Productivity