19. Coagulation cascade XII XI IX X VIII Prothrombin (II) thrombin fibrinogen fibrin STABILISED FIBRIN V, Ca, P/L VII Intrinsic pathway Extrinsic pathway XIII APTT PT
20. X Xa II (Prothrombin) IIa (Thrombin) INITIATION VIIa TF Va VIIIa Va XIa
21. AMPLIFICATION IXa Xa-Va-II Prothrombinase Platelet IXa- VIIa-X “ tenase” TF IX VIIa THROMBIN (IIa) FIBRIN
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Notes de l'éditeur
Essential cofactor for FVIIa FVIIa: inefficient serine protease. Complex with TF and oriented to phospholipid membrane Phospholipid surface increases the rate of substrate activation (FX, FIX) by 10 4 -10 7