This document discusses serotonin syndrome, which can occur when certain medications increase serotonin levels in the brain. It provides: 1) An overview of serotonin syndrome including symptoms, risk factors like concurrent use of serotonergic drugs, and diagnostic criteria. 2) A case example of Libby Zion, an 18-year-old who died of serotonin syndrome after being given multiple medications. This led to reforms limiting resident work hours. 3) Management recommendations for serotonin syndrome focusing on removing precipitating drugs and using 5-HT antagonists like cyproheptadine to control symptoms. Close monitoring is needed due to the risk of rapid progression.

1. Serotonin Syndrome Gabriel Tsao, MS3 Ben Berk, MS4 Gabriel Tsao, MS3 Stanford University School of Medicine Left Brain vs Right Brain