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Non-Cardiac Chest Pain Oesophagus: Acid Reflux & Motility Disorders Differentiating Heartburn Abeezar I. Sarela MS MSc MD FRCS Consultant in Upper Gastrointestinal & Minimally Invasive Surgery The General Infirmary at Leeds Wharfedale General Hospital Nuffield Hospital Leeds BUPA Hospital Leeds
History of Non-Cardiac Chest Pain (NCCP)
Coronary vs Non-Coronary Chest Pain
Non-Cardiac Chest Pain in A&E
Prediction Of Cardiac Pain vs NCCP by History
Characteristics of Oesophageal Chest Pain ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
To Whom Shall I Refer?
Mechanisms Of Oesophageal Chest Pain
Oesophageal Causes of Non-Cardiac Chest Pain
Mechanisms For Induction Of Heartburn
Abnormal Oesophageal Motility In  Non-Cardiac Chest Pain
Oesophageal Causes Of Chest Pain In Cardiac Disease
Overlap Concept Of Altered Pain Sensitivity
Therapeutic Trial of PPI in Non-Cardiac Chest Pain
Investigations for Suspected GORD ,[object Object],[object Object]
Provocation Tests Acid-perfusion
24-hr Ambulatory Oesophageal pHmetry
24-hr Ambulatory Oesophageal pHmetry
[object Object],[object Object],[object Object],[object Object],[object Object],24-hr Ambulatory Oesophageal pHmetry
Achalasia Of The Oesophagus
Diffuse Oesophageal Spasm
Oesophageal Manometry GORD
Achalasia Cardia
Gastroesophageal Reflux Disease ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
GORD Treatment ,[object Object],[object Object],[object Object],[object Object]
Anti-Reflux Surgery NICE Guidance, 2005 ,[object Object]
Indications for Surgery ,[object Object],[object Object]
Indications for Surgery ,[object Object],[object Object]
Indications for Surgery ,[object Object],[object Object]
Indications for Surgery ,[object Object],[object Object]
Indications for Surgery ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Nissen (360 degree) Fundoplication For Gastroesophageal Reflux
Immediate Post-operative Issues ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Outcomes ,[object Object],[object Object],[object Object],[object Object],[object Object]
Achalasia Cardia Treatment Options ,[object Object],[object Object],[object Object]
Summary of Surgical Options ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Conclusions ,[object Object],[object Object],[object Object],[object Object],[object Object]

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Non cardiac chest pain

Notes de l'éditeur

  1. Figure 10-1. Major developments in the history of noncardiac chest pain (NCCP). The early descriptions of patients with chest pain refer to the interplay of emotional issues or possible altered pain perception with disordered function of the esophagus [],[],[],[],[]. Following the development of esophageal manometric recording, esophageal motor disorders were specifically defined and found in association with symptoms in patients with NCCP [],[],[]. Studies using provocative or prolonged ambulatory esophageal events permitted a correlation of symptoms with defined esophageal events. More recently, an overlap concept has emerged, linking the "irritable esophagus" with "sensitive heart" (microvascular angina) and panic disorder, as associated causes of chronic chest pain.
  2. Figure 10-2. Coronary versus noncoronary chest pain. Coronary arteriography demonstrates abnormal anatomy in about 70% of patients with chest pain. The remaining patients have their symptoms arising from diverse origins, including esophageal, cardiac, pulmonary, psychiatric, musculoskeletal, and other causes. In patients with noncardiac chest pain (NCCP) referred for esophageal testing, about 50% are found to have an associated esophageal cause [],[],[],[]. EMD—esophageal motor disorder; GERD—gastroesophageal reflux disease.
  3. Figure 10-3. Prevalence of noncardiac chest pain in patients presenting to the emergency room. In a multicenter trial, 10,689 patients who presented with chest pain or symptoms suggestive of acute myocardial ischemia were followed for one month. Ultimately 17% met the criteria for acute myocardial ischemia, while 21% had other cardiac problems. The remaining 55% had noncardiac causes of their chest pain, emphasizing the high prevalence of this disorder [].
  4. Figure 10-7. Prediction of cardiac versus noncardiac causes of chest pain by history. Interviews were conducted prior to diagnostic coronary angiography with 248 patients with chest pain. Cardiologists classified 185 patients as having typical anginal pain, while 63 patients were believed to have noncoronary chest pain. Interestingly, 26% of the patients with typical anginal pain had normal coronary angiography while 25% of patients deemed noncardiac had abnormal angiograms. Thus the cardiologist was incorrect 25% of the time in each group using history alone. These data suggest that history alone is not an accurate predictor of the source of chest pain, and exclusion of a cardiac source should always precede the search for an esophageal etiology [].
  5. Figure 10-8. Mechanisms of esophageal chest pain. Sensation from the esophagus travels to the central nervous system (CNS) by pathways of the sympathetic and parasympathetic systems, and involves stimulation of esophageal chemoreceptors, mechanoreceptors, thermoreceptors, and nociceptors []. The specific mechanisms producing esophageal chest pain are not well understood. Investigation has centered on the evaluation of esophageal sensitivity to chemical and mechanical stimuli; the finding that multiple stimuli may produce identical symptoms in some individuals with chest pain has led to the acceptance of the concept of an irritable esophagus [],[]. Although acid sensitivity from gastroesophageal reflux is believed to be a source of noncardiac chest pain (NCCP), the relationship between acid reflux events and symptoms is poor, with the majority of reflux events not found to cause symptoms during prolonged pH monitoring []. A potential role of more proximal esophageal acid exposure in causing chest pain is suggested by a recent study [], which also suggested that patients with chest pain without heartburn symptoms differ from those who have these symptoms by having lower overall acid-reflux parameters. Although the temperature of an ingested bolus may alter esophageal motility, warmth increases speed and frequency of peristaltic contractions [], whereas cold results in a relative paralysis and distention of the distal esophagus [], it has not been clearly shown that patients with NCCP have altered temperature-induced sensitivity when compared with asymptomatic controls. It had been proposed that hyperosmolarity of ingested substances could be a mechanism for production of chest symptoms, but infusion of a hypertonic liquid failed to produce chest pain in at least one study of patients with NCCP []. Sensitivity to mechanical stimuli has been demonstrated with intraesophageal balloon distention studies in patients with NCCP, a positive test result providing reproduction of usual pain symptoms with inflation of the balloon. Acute distention as a mechanism for pain has been suggested from a study of dysfunction of the belch reflex in some individuals []. Esophageal myoischemia has been proposed as a possible mechanism for pain when intense esophageal contactile activity might interrupt the usual intramural blood flow [].
  6. Figure 10-9. Mechanisms of esophageal chest pain: issues. Acid reflux may induce esophageal motility changes with possible chest symptoms, but it also may provoke bronchial or cardiac reflexes involved in pain sensation from the chest. Patients with noncardiac chest pain (NCCP) often have documented esophageal motility disorders, but the relationship between abnormal contraction patterns and pain symptoms is not well understood. Motility disturbances found at the time of stationary esophageal testing are most often asymptomatic; motility changes documented at prolonged monitoring are also often not symptomatic. Some have suggested that these changes in motility should be viewed as an epiphenomenon of chronic chest pain [], rather than causative of symptoms. In patients with NCCP simultaneously monitored for acid reflux and dysmotility, many patients are discovered to have multiple causes to explain their symptoms [],[], suggesting esophageal sensitivity to various stimuli is capable of producing identical chest pain symptoms (the irritable esophagus , previously mentioned) [],[]. EMD—esophageal motility disorders; GERD—gastroesophageal reflux disease.
  7. Putative mechanisms involved in the induction of heartburn symptoms.
  8. Figure 10-20. Abnormal esophageal motility was present in 255 (28%) of 910 patients in whom noncardiac chest pain (NCCP) was evaluated []. Most of these patients had nutcracker esophagus or nonspecific motility disorders; the other primary motor disorders of achalasia, hypertensive lower esophageal sphincter, and diffuse eophageal spasm were found less commonly. These findings have been confirmed by others [],[],[]. Although some of the motor disorders may directly relate to causation of pain through mechanisms of spasm and distention, most investigators now consider the esophageal motility disorders to be an epiphenomenon found in patients with chronic chest pain or as a response to stress [],[]. Contributing to this changing view are data that demonstrate that pain is most often not present during stationary manometry when abnormal motor events are recorded; it is the minority of patients undergoing ambulatory motor studies who have a motility disorder during an episode of pain []. The findings that successful resolution of chest pain symptoms may occur in the absence of any significant change in the underlying esophageal motor abnormalities [], and that esophageal motility disorders may be treated with little effect on chest pain symptoms [] have encouraged questions about the etiologic role of motor disorders in NCCP. Of further interest is the finding that 35% of patients with nutcracker esophagus were shown to have evidence of gastroesophageal reflux disease and that acid-suppressive therapy improved symptoms in 83% []. An alternative mechanism of pain in patients with nutcracker esophagus was suggested by a recent report that demonstrated a hypersensitive and stiff esophagus as measured by balloon distention and impedance planimetry []. DES—diffuse esophageal spasm; LES—hypertensive lower esophageal sphincter; NEMD—nonspecific esophageal motility disorders. ( Adapted from Richter [].)
  9. Figure 10-27. Esophageal causes of chest pain may coexist in patients with demonstrated cardiac disease. Esophageal motility disorders and gastroesophageal reflux disease have been documented in from 10% to 67% of patients with abnormal coronary arteriograms and angina-like chest pain [],[],[]. In patients with microvascular angina and atypical chest pain, esophageal disorders can be documented in 23% to 75% [],[],[]. A recent report suggests that esophageal hypersensitivity rather than esophageal dysmotility was an important factor in development of chest pain in patients with syndrome X, and that acid suppression could ameliorate pain in a substantial proportion of patients for whom abnormal acid sensitivity was the main culprit []. From 52% to 86% of patients with chest pain and documented mitral valve prolapse are shown to have esophageal disorders as evidenced by routine and provocative testing [],[],[]. Interestingly, gastroesophageal reflux may lower the anginal threshold in some patients []; some investigators have shown esophageal acid perfusion to induce electrocardiographic changes of myocardial ischemia, or to reduce coronary blood flow via a neural reflex [],[], although two other reports do not support this finding [],[].
  10. Figure 10-29. Emerging overlap concept of altered pain sensitivity. Patients with panic disorders score high in measures of anxiety and hypochondriasis, and panic attack symptoms overlap with those of chest pain of esophageal origin and microvascular angina having fear of dying, shortness of breath, choking or smothering sensation, palpitations, chest pain or discomfort, sweating, faintness, dizziness, and nausea, among others. Patients with microvascular angina have been shown to have frequent demonstrable esophageal motility disorders and heightened visceral awareness of acid exposure and esophageal distension. Abnormal nociception may link esophageal with coronary smooth muscle sensitivity; patients with microvascular angina frequently have their pain provoked during injection of intracoronary contrast media and, as has been pointed out, patients with chest pain of esophageal origin may have heightened sensitivity to esophageal distension with balloon provocation. Investigators have shown a co-occurrence that is common between panic disorder symptoms and mitral valve prolapse. This is not likely cause and effect, but rather a heightened sensitivity in the susceptible patient. A generalized disorder of smooth muscle sensitivity gives rise to the "irritable person," manifesting itself with symptoms referable to the esophagus, the bowel, the heart, or other organ systems. These various symptoms arise as physiologic responses to stress. A comprehensive approach to diagnosis and treatment in the patient with atypical chest pain is mandatory. GERD—gastroesophageal reflux disease; EMD—esophageal motility disorders.
  11. Figure 10-17. Economic and clinical value of the proton pump inhibitor test in patients with noncardiac chest pain (NCCP). In a cross-over design, 39 patients with frequent NCCP were randomized to receive high-dose omeprazole (40 mg a.m., 20 mg p.m.) or placebo for 1 week. Using 24-hour pH probe monitoring as the gold standard, the sensitivity of the omeprazole test was found to be 78% and the specificity 86%. Economic analysis showed an average cost savings of $573 per patient and a 59% reduction in number of procedures performed when empiric high-dose omeprazole use was compared with standard evaluation on NCCP []. These results add to the findings of previous investigators who had demonstrated improvement in chest pain symptoms in 81% of gastroesophageal reflux disease-positive NCCP patients receiving high-dose omeprazole versus 6% improvement from placebo [].
  12. Figure 10-12. Acid-perfusion (Bernstein) test. As originally described by Bernstein and Baker [], a patient is seated upright with a nasogastric tube placed into the midesophagus and, with the patient blinded to the administration, normal saline solution and dilute hydrochloric acid (0.1 N HCl) are alternatively infused into the esophageal lumen. A positive test result is one in which acid infusion produces the patient's usual chest pain, whereas infusion of saline does not and in fact may relieve the symptoms provoked by the acid. The cause of pain from acid perfusion of the esophagus has been attributed to triggered chemoreceptors, induction of dysmotility, or acid sensitivity of normal and inflamed mucosa.
  13. Figure 9-4. Barium swallow in a patient with achalasia of the esophagus. This study shows a dilated esophagus in a patient with achalasia of the lower esophageal sphincter ( A ). The gastroesophageal junction does not open, resulting in a classical bird's beak appearance at the distal end of the esophagus ( B ). The serrated margin ( arrow ) in the midesophagus is referred to by radiologists as tertiary contractions .
  14. Figure 9-12. Barium swallow study in a patient with diffuse esophageal spasm. Note the corkscrew or rosary-bead appearance along the length of the distal esophagus.
  15. Figure 6-45. Surgical management. Patients who are successfully controlled with acid suppressant therapy but do not desire to remain on medications lifelong are candidates for antireflux surgery. The most commonly performed surgical procedures for gastroesophageal reflux disease are the Hill gastropexy ( A ), Belsey (partial) fundoplication ( B ), and Nissen (complete) fundoplication ( C ) []. The Nissen procedure is the most popular and can be performed either as an open procedure or using the laparoscopic approach. The laparoscopic Nissen procedure has an initial failure rate of approximately 10% and an approximate 1% breakdown of the wrap each year. The procedure itself carries little mortality risk, but morbidity rates, including esophageal perforations, wound infections, splenic tears, postoperative dysphagia, and gas bloat, occur in about 10% of patients. The cost of a successful Nissen procedure is estimated to be equivalent in cost to 10 years of chronic proton pump inhibitor (PPI) therapy, but this analysis will change in favor of PPI therapy after a generic version is available in 2002. ( Adapted from Pope [].)